OBM Neurobiology is an international peer-reviewed Open Access journal published quarterly online by LIDSEN Publishing Inc. By design, the scope of OBM Neurobiology is broad, so as to reflect the multidisciplinary nature of the field of Neurobiology that interfaces biology with the fundamental and clinical neurosciences. As such, OBM Neurobiology embraces rigorous multidisciplinary investigations into the form and function of neurons and glia that make up the nervous system, either individually or in ensemble, in health or disease. OBM Neurobiology welcomes original contributions that employ a combination of molecular, cellular, systems and behavioral approaches to report novel neuroanatomical, neuropharmacological, neurophysiological and neurobehavioral findings related to the following aspects of the nervous system: Signal Transduction and Neurotransmission; Neural Circuits and Systems Neurobiology; Nervous System Development and Aging; Neurobiology of Nervous System Diseases (e.g., Developmental Brain Disorders; Neurodegenerative Disorders).

OBM Neurobiology publishes research articles, technical reports and invited topical reviews. Although the OBM Neurobiology Editorial Board encourages authors to be succinct, there is no restriction on the length of the papers. Authors should present their results in as much detail as possible, as reviewers are encouraged to emphasize scientific rigor and reproducibility.

Indexing: DOAJ-Directory of Open Access Journals.

Archiving: full-text archived in CLOCKSS.

Rapid publication: manuscripts are undertaken in 7.5 days from acceptance to publication (median values for papers published in this journal in the first half of 2020, 1-2 days of FREE language polishing time is also included in this period).

Free Publication in 2020
Current Issue: 2020  Archive: 2019 2018 2017

Special Issue

Tumors of the Central Nervous System

Submission Deadline: October 15, 2018 (Closed) Submit Now

Guest Editor

Antonio Meola, M.D. Ph.D

Clinical Instructor in Neurosurgery, Department of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Drive, Edwards Bldg. 94304, Stanford, CA

Website | E-Mail

Research Interests: Brain Tumors, Skull Base Surgery, Image-guided Neurosurgery, Radiosurgery

About This Topic

The WHO classification of Tumors of the Central Nervous System (CNS) highlighted the pivotal role of molecular and genetic markers for predicting tumor biological behavior, therapy response and patient prognosis. We seek original research articles focusing on genetic, molecular and radiological features of CNS tumors that might impact on clinical practice, including clinical and preclinical data. Additionally, we invite submission of reviews, editorials, case reports, technical reports elucidating biological features of the CNS tumors, the interaction of tumors with healthy nervous tissue, as well as illustrating the effect of medications and cutting-edge technology on CNS tumor diagnosis and treatment.

Publication

Open Access Editorial

Editorial: “A New Era in Neuro-Oncology”

Received: 05 May 2019;  Published: 08 May 2019;  doi: 10.21926/obm.neurobiol.1902025
Open Access Review

Diffuse Intrinsic Pontine Glioma: Translation of Genomic Knowledge to Clinical Practice

Received: 29 November 2018;  Published: 12 March 2019;  doi: 10.21926/obm.neurobiol.1901022

Abstract

Pediatric brain tumors account for approximately 25% of all cancers in children and are currently the leading cause of cancer-related deaths in the pediatric population with an estimated incidence of 5.14 cases per 100,000 persons [1]. Up to 10-15% of all pediatric brain tumors arise in the brainste [...]
Open Access Review

Sporadic and Hereditary Hemangioblastoma: The Role of Endothelial Cells

Received: 26 November 2018;  Published: 04 March 2019;  doi: 10.21926/obm.neurobiol.1901021

Abstract

Hemangioblastomas (HBs) are benign, highly vascularized tumors of the central nervous system. About 75% of HBs are sporadic, while 25% are associated with von Hippel-Lindau (VHL) disease. HBs consist of two main components, a rich capillary network composed of vascular endothelia and pericytes, with [...]
Open Access Research Article

Magnetic Resonance Imaging Approaches for Predicting the Response to Hyperoxic Radiotherapy in Glioma-Bearing Rats

Received: 11 November 2018;  Published: 30 January 2019;  doi: 10.21926/obm.neurobiol.1901020

Abstract

Background: Despite the advances in multimodal therapeutic options, glioblastoma (GBM), the most frequent and aggressive of all astrocytomas, remains with a median survival of 15 months. It is reported a direct correlation between GBM hypoxia and a higher aggressiveness, poor prognosis and greater r [...]
Open Access Research Article

Correlation of CT and MR Perfusion and Permeability Parameters for Intracranial Tumors

Received: 07 October 2018;  Published: 13 January 2019;  doi: 10.21926/obm.neurobiol.1901019

Abstract

Background and Purpose: Perfusion imaging, mainly MR perfusion (MRP), is performed frequently for brain tumor imaging. CT perfusion (CTP) is less studied as a method for characterizing brain tumors. The purpose of this study was to demonstrate the usefulness of CTP perfusion parameters in evaluating [...]
Open Access Case Report

Cerebellopontine Angle Glioblastoma with Concurrent Spinal Cord Involvement: A Case Report and Review of Literature

Received: 12 November 2018;  Published: 04 January 2019;  doi: 10.21926/obm.neurobiol.1901018

Abstract

Objective: To report a unique case of cerebellopontine angle glioblastoma with concurrent spinal cord involvement. Background: Glioblastoma (GBM) is the most common primary malignancy of the central nervous system (CNS), comprising 46.6% of all CNS malignancies. By anatomic location, cerebelloponti [...]
Open Access Review

Sleep Disorders in Children with Central Nervous System Tumors

Received: 13 November 2018;  Published: 16 December 2018;  doi: 10.21926/obm.neurobiol.1804017

Abstract

Sleep complaints are common in pediatric patients with central nervous system (CNS) tumors. These problems may result from disruption of normal homeostatic, circadian, neuroendocrine, and cardiorespiratory pathways and vary by tumor location and treatment received. Children with tumors within the hy [...]
Open Access Original Research

TTF-1-Expressing Supratentorial Embryonal Tumors (PNET): A Clinicopathologic Study of Two Cases and Literature Review of TTF-1-Positive Primary Brain Tumors

Received: 07 October 2018;  Published: 14 November 2018;  doi: 10.21926/obm.neurobiol.1804016

Abstract

Thyroid transcription factor 1 (TTF-1) is a nuclear polypeptide, tissue-restricted member of the homeobox protein family, that when attached to DNA plays a crucial role in regulating the expression of select genes during early embryonic development of the thyroid, lung, and brain. As often happens, [...]
Open Access Review

Angiocentric Glioma: A Review of Clinicopathologic Features

Received: 04 September 2018;  Published: 05 November 2018;  doi: 10.21926/obm.neurobiol.1804015

Abstract

Along with focal cortical dysplasia, hippocampal sclerosis and remote infarcts, tumors are a well known cause of medically intractable or pharmacoresistent epilepsy [1-3]. Most of the tumors encountered in this setting represent low grade glioneuronal neoplasms, particularly gangliogliomas and dyse [...]
Open Access Case Report

A Case Series of Temozolomide in the Management of Refractory Prolactinomas

Received: 12 October 2018;  Published: 01 November 2018;  doi: 10.21926/obm.neurobiol.1804014

Abstract

Objective: To report three cases of refractory prolactinomas treated with Temozolomide (TMZ). Background: Prolactinomas account for 40% of pituitary adenomas. Dopamine agonists (DA) are the first line of treatment followed by surgical resection and radiation. TMZ is an oral chemotherapeutic agent us [...]
Open Access Research Article

Isolated Diffusion Restriction Preceding Contrast Enhancement in Glioblastoma Multiforme is Associated with Short-Term Survival

Received: 07 August 2018;  Published: 25 October 2018;  doi: 10.21926/obm.neurobiol.1804013

Abstract

Background: Current imaging standard for detecting and assessing glioblastoma multiforme (GBM) progression depends on contrast-enhancement on brain magnetic resonance imaging (MRI). Isolated foci of diffusion restriction have been observed to precede enhancement in GBM. The aim of our study was to i [...]
Open Access Review

Craniopharyngiomas: An Appropriate Surgical Treatment based on Topographical and Pathological Concepts

Received: 11 September 2018;  Published: 15 October 2018;  doi: 10.21926/obm.neurobiol.1804012

Abstract

Treatment of craniopharyngiomas (CPs) represents a neurosurgical challenge, the major reason being their close relationship with the hypothalamus and the third ventricle (3V) boundaries. Nevertheless, CPs are generally defined as “suprasellar” lesions, an imprecise and frequently faulty term. Despit [...]
Open Access Review

Contribution of PET Imaging to Clinical Management of Gliomas

Received: 02 July 2018;  Published: 19 September 2018;  doi: 10.21926/obm.neurobiol.1803011

Abstract

Gliomas originating from glial cells, comprise about 30 % of all primary central nervous system tumors and 80 % of malignant brain tumors. Gliomas are different with respect to their biological activity and are categorized according to grades, from benign to malignant with high recurrence rates. For [...]
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