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Open Access Review

Nutritional Management for Infants and Children Pre and Post-Liver Transplant

Melissa Mortensen, Christine Lundberg, Simon Horslen
Received: December 05, 2018; Published: July 17, 2019; doi:10.21926/obm.transplant.1903073

Abstract: Background: Infants and children undergoing liver transplant require ongoing nutritional evaluation throughout the pre and post-transplant period. The pathophysiologic causes of chronic liver disease and acute liver failure are varied, and each present different and unique nutritional challenges. Me [...]

Open Access Review

Single Cell Transcriptomic Analysis of Pancreatic β Cell Development and Differentiation from Pluripotent Stem Cells

Chunhui Xie, Lillian Ye, Yeh-Chuin Poh, George Harb
Received: May 06, 2019; Published: July 17, 2019; doi:10.21926/obm.transplant.1903072

Abstract: Single cell genomics is a powerful tool to study cellular heterogeneity and discover novel cell types. Recent studies used single cell RNA sequencing (scRNA-seq) to analyze the transcriptomes of individual pancreatic islet cells. Islets are a complex mixture of endocrine cells and therefore represen [...]

Open Access Research Article

A Simple and Effective Non-Human Primate Diabetic Model Combining Sub-Total Pancreatectomy and Low-Dose Streptozotocin Injection

Ibrahim Fathi, Takehiro Imura, Kozue Imura, Megumi Goto, Yasuhiro Igarashi, Akiko Inagaki, Makiko Kikkawa, Fumiko Ono, Hiroo Iwata, Yohichi Yasunami, Masafumi Goto
Received: March 27, 2019; Published: July 09, 2019; doi:10.21926/obm.transplant.1903071

Abstract: BACKGROUND. Current non-human primate diabetic models, namely those induced by total pancreatectomy or streptozotocin (STZ) injection, suffer from several disadvantages, including a long surgical procedure, the need for continual digestive enzyme replacement, and a delayed oral intake after total pa [...]

Open Access Review

Clinical Tolerance Trials in Renal Transplantation – Where Do We Stand?

Joachim Andrassy, Antje Habicht
Received: November 05, 2018; Published: June 27, 2019; doi:10.21926/obm.transplant.1902070

Abstract: In recent years, the potential of hematopoietic stem cells, regulatory T-cells and mesenchymal stem cells resulted in a variety of clinical tolerance trials. Every approach has yielded promising results. However, the riddle of transplant tolerance has not been solved as of yet. The results of the on [...]

Open Access Research Article

The DPP4 Inhibitor Sitagliptin Increases Active Glp-1 Levels from Human Islets and May Increase Islet Cell Survival Prior to Transplantation

Scott A. Campbell, Matthew Hubert, Janyne Johnson, Nicole Salamon, Peter E. Light
Received: March 12, 2019; Published: June 26, 2019; doi:10.21926/obm.transplant.1902069

Abstract: Background One of the goals of clinical islet transplantation is to achieve a single-donor transplant that is dependent on obtaining enough quality  cell mass from one donor pancreas. Human islets are routinely cultured prior to transplantation, and pro-survival factors such as GLP-1 analogues have [...]

Open Access Review

Human Islet Isolation and Distribution Efforts for Clinical and Basic Research

Natasha Hui Jin Ng, Wei Xuan Tan, Ye Xin Koh, Adrian Kee Keong Teo
Received: March 11, 2019; Published: June 21, 2019; doi:10.21926/obm.transplant.1902068

Abstract: The ability to obtain purified human islets routinely and reproducibly has enabled substantial progress in providing a safe and reliable treatment option for adult Type 1 diabetes patients. The availability of human islets for basic research has also significantly impacted the progress of understand [...]

Open Access Original Research

Ex-Vivo Perfusion of Donor Hearts: The Feasibility of Banked Blood for Normothermic Machine Perfusion

Hong Chee Chew, Ling Gao, Jeanette E. Villaneuva, Aoife Doyle, Mark Hicks, Andrew Jabbour, Kumud K. Dhital, Peter S. Macdonald
Received: March 09, 2019; Published: June 18, 2019; doi:10.21926/obm.transplant.1902067

Abstract: Background: Normothermic machine perfusion (NMP) utilises 1.2-1.5L of donor blood (DB) with a target perfusate haematocrit of 25% to reanimate the donor heart. Limitations to current practise include small donor size and donor anaemia which can impact on the recovery of these hearts. Furthermore, in [...]

Open Access Review

Non-CMV Viral Infections Following Solid-Organ Transplantation – Focus on Human T-Cell Lymphotropic Virus Type-1 and Human Herpesviruses-6,-7 and -8

Katerina G. Oikonomou, Sarah Taimur
Received: February 14, 2019; Published: June 17, 2019; doi:10.21926/obm.transplant.1902066

Abstract: In non-endemic areas, HTLV-1 is an uncommon pathogen in the transplant host but can be associated with significant morbidity and mortality. Careful assessment of risk factors, targeted screening and heightened awareness of the clinical presentation of HTLV-1 associated disease is necessary for timel [...]

Open Access Review

Respiratory Viral Infections in Lung Transplant Recipients: Implications for Long Term Outcomes and Emerging Therapies

Sheila Krishnan, Chadi Hage, Raymond Coakley, David van Duin, Leonard Jason Lobo
Received: February 18, 2019; Published: June 10, 2019; doi:10.21926/obm.transplant.1902065

Abstract: Lung transplant recipients are at greater risk of respiratory viral infections as compared to other solid organ transplant recipients due to constant exposure of the allograft to the external environment. There are no standardized methods for surveillance, prevention, or treatment of these infectio [...]

Open Access Original Research

Low Cost, Enriched Collagenase-Purified Protease Enzyme Mixtures Successfully Used for Human Islet Isolation

Gopalakrishnan Loganathan, Michael G. Hughes, Gregory L. Szot, Kate E. Smith, Abid Hussain, Daniel R. Collins, Michael L. Green, Francis E. Dwulet, Stuart K. Williams, Klearchos K. Papas, Robert C. McCarthy, Appakalai N. Balamurugan
Received: March 29, 2019; Published: May 24, 2019; doi:10.21926/obm.transplant.1902064

Abstract: Background: Purified bacterial collagenase and protease enzymes are commonly used to recover human islets from clinical grade pancreata for subsequent clinical islet transplantation. The high cost of purified enzymes can be prohibitive for recovering human islets from research pancreata used for tra [...]

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