Enhancing Bone Union in Aseptic Femoral Shaft Nonunion by Multimodal Autologous Bone Graft and Mechanical StabilizationAbstract Aseptic femoral shaft nonunion represents a biologically compromised state in which impaired osteogenesis, insufficient vascularity, and inadequate mechanical stability prevent healing. Although mechanical revision is essential, achieving union often requires effective autologous bone tissue transpl [...] 55 185 |
Utilization Patterns and Safety Profile of Immunosuppressive Regimen among Kidney Transplant Recipients: A Descriptive Pharmacoepidemiological Study from a Tertiary Hospital in IndonesiaAbstract Kidney transplantation is the preferred therapy for end-stage kidney disease (ESKD), but long-term success is greatly influenced by the selection and safety of immunosuppressants. Local data on prescribing patterns and the incidence of drug side effects in Indonesia are still limited. Therefore, thi [...] 171 642 |
Development of New Macroencapsulating Planar Devices to Inhibit Allorejection of Islet Transformed Cellsby
Douglas O. Sobel
and
Keerat Parmar
Abstract Subcutaneous transplantation of islets into small-pore macroencapsulation devices that prevent immune cell passage can inhibit allorejection in rodents. However, there are no reports of euglycemia in humans using this technology. This report further develops these macroencapsulation devices. We comp [...] 246 980 |
Development of Methods for Transplanting Human Islet within Macroencapsulation Device that Reverse Diabetes in Miceby
Douglas Sobel
and
Wanxing Cui
Abstract Transplanting islets into the subcutaneous (SC) space rather than the portal vein is advantageous because this site is easier and safer to use. However, transplantation of islets directly or within planar devices has been unsuccessful in humans, mainly because of the low oxygen torr in t [...] 323 1376 |
Novel Therapies for the Treatment of Antibody Mediated Rejection in Solid Organ Transplantation: A Systematic Reviewby
Alisia Chen
and
Jeong M. Park
Abstract Antibody mediated rejection (AMR) is a considerable cause of late allograft failure in solid organ transplantation. Conventional approaches, using plasmapheresis, intravenous immunoglobulin, rituximab, bortezomib, and eculizumab have been unsuccessful in improving graft survival. This review aims to [...] 640 2961 |
Nutrition and Transplant OutcomesAbstract Dietary guidelines and Nutrient Reference Intakes are important tools for maintaining optimal health in the general population. Similar guidelines have also been developed by specific organ health associations to help their patient populations recover from disorders or prevent/delay clinical events [...] 551 1310 |
Balancing Preservation and Maximizing Utilization: A DCD Lung Procurement Strategy During Abdominal Normothermic Regional Perfusionby
Chawannuch Ruaengsri
,
Miguel Alvarez-Cortes
,
Marc Leon
,
Manuel Quiroz-Flores
,
Masafumi Shibata
and
Yasuhiro Shudo
Abstract The increasing demand for organ transplantation has necessitated innovative strategies to maximize donor organ utilization, especially in donation after circulatory death (DCD) contexts. This article explores the integration of direct lung recovery with abdominal normothermic regional perfusion (A-N [...] 596 2096 |
Machine Perfusion in DCD Lung Transplantation: Advances in Preservation and Donor Pool Expansionby
Chawannuch Ruaengsri
,
Marc Leon
,
Miguel Alvarez-Cortes
,
Manuel Quiroz-Flores
and
Yasuhiro Shudo
Abstract To address the pressing shortage of donor lungs, Donation after Circulatory Death (DCD) transplantation has become a vital strategy for expanding the donor pool. Minimizing warm ischemic injury is crucial for optimizing organ viability and function. This review synthesizes current evidence on Normot [...] 721 2880 |
Acknowledgment to Reviewers of OBM Transplantation in 2025Abstract The editors of OBM Transplantation would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2025. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize rev [...] 475 1275 |
Pharmacological Strategies to Enhance Bone Graft Integration: Emerging Agents and Molecular PathwaysAbstract Bone grafting remains a cornerstone technique in orthopedic and reconstructive surgery, yet achieving successful graft integration continues to pose significant challenges, particularly in conditions such as osteoporosis, diabetes mellitus, and large bone defects. Traditional graft materials such as [...] 1850 4377 |
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