OBM Geriatrics

(ISSN 2638-1311)

OBM Geriatrics is an Open Access journal published quarterly online by LIDSEN Publishing Inc. The journal takes the premise that innovative approaches – including gene therapy, cell therapy, and epigenetic modulation – will result in clinical interventions that alter the fundamental pathology and the clinical course of age-related human diseases. We will give strong preference to papers that emphasize an alteration (or a potential alteration) in the fundamental disease course of Alzheimer’s disease, vascular aging diseases, osteoarthritis, osteoporosis, skin aging, immune senescence, and other age-related diseases.

Geriatric medicine is now entering a unique point in history, where the focus will no longer be on palliative, ameliorative, or social aspects of care for age-related disease, but will be capable of stopping, preventing, and reversing major disease constellations that have heretofore been entirely resistant to interventions based on “small molecular” pharmacological approaches. With the changing emphasis from genetic to epigenetic understandings of pathology (including telomere biology), with the use of gene delivery systems (including viral delivery systems), and with the use of cell-based therapies (including stem cell therapies), a fatalistic view of age-related disease is no longer a reasonable clinical default nor an appropriate clinical research paradigm.

Precedence will be given to papers describing fundamental interventions, including interventions that affect cell senescence, patterns of gene expression, telomere biology, stem cell biology, and other innovative, 21st century interventions, especially if the focus is on clinical applications, ongoing clinical trials, or animal trials preparatory to phase 1 human clinical trials.

Papers must be clear and concise, but detailed data is strongly encouraged. The journal publishes research articles, reviews, communications and technical notes. There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.

Archiving: full-text archived in CLOCKSS.

Rapid publication: manuscripts are undertaken in 12 days from acceptance to publication (median values for papers published in this journal in 2021, 1-2 days of FREE language polishing time is also included in this period). 

Open Access Short Report

Creation of an Operational Dashboard to Document Implementation of 4M’s into Primary Care in a Geriatric Patient-Centered Medical Home

Received: 05 June 2022;  Published: 28 September 2022;  doi: 10.21926/obm.geriatr.2203205

Abstract

Many health systems have joined the Age-Friendly Health Systems movement to provide every older adult safe, high-quality care aligned with what matters most. Becoming an Age-Friendly Health System means that hospitals and health care systems reliably use a set of evidence-based practices known as the “4M’s” – What Matters, Medication, Mentation [...]

Open Access Case Report

Sleep Disorders in Older People with Special Focus on Parkinson’s Disease

Received: 01 July 2022;  Published: 13 September 2022;  doi: 10.21926/obm.geriatr.2203204

Abstract

This paper examines sleep disorders in older people, focusing on Parkinson’s disease (PD). It defines PD and explores those conditions associated with sleep disorders and their relationship to PD. It identifies specific conditions which cause sleep disoders in patients with PD, namely: REM sleep behaviour disorder (RDB) which may be a precursor to [...]

Open Access Original Research

A Retrospective Study of Progressive Gait Impairment in Alzheimer’s Disease

Received: 27 December 2021;  Published: 08 September 2022;  doi: 10.21926/obm.geriatr.2203203

Abstract

Individuals with Alzheimer’s disease (AD) and Mild Cognitive Impairment (MCI) have increased gait disturbances throughout disease progression. However, an understanding of gait impairment and progression in early versus late AD is lacking. Further, the longitudinal progression of gait impairment in AD as well as in those with MCI that transition to [...]

Open Access Review

Polymyalgia Rheumatica, an Age-Related Rheumatic Disease

Received: 07 May 2022;  Published: 27 July 2022;  doi: 10.21926/obm.geriatr.2203202

Abstract

Polymyalgia rheumatica (PMR) is an age-related chronic inflammatory disease with rheumatic features at the fore. In addition to the high-grade systemic inflammation, it is characterized by typical “polymyalgic” musculoskeletal symptoms, including diffuse and severe pain and prolonged morning stiffness of the shoulder girdle, pelvic girdle, and neck [...]

Open Access Interview

An Interview with Dr. Koh Iwasaki

Received: 01 July 2022;  Published: 03 July 2022;  doi: 10.21926/obm.geriatr.2203201

Open Access Review

Complex Pathology of Cardiac Syncope in Old Patients

Received: 07 February 2022;  Published: 16 June 2022;  doi: 10.21926/obm.geriatr.2202200

Abstract

Syncope is characterized by a transient and rapid loss of consciousness for a short duration, with full spontaneous recovery within minutes. Syncope causes up to 2% of all emergency medical consultations. The incidence of syncope is similar in men and women, is higher in old patients (slightly higher in old women). The prevalence of syncope is up to [...]

Open Access Interview

An Interview with Dr. Carlo Pedrolli

Received: 01 June 2022;  Published: 09 June 2022;  doi: 10.21926/obm.geriatr.2202199

Abstract

InterviewAn Interview with Dr. Carlo PedrolliOBM Geriatrics Editorial OfficeLIDSEN Publishing Inc., 2000 Auburn Drive, One Chagrin Highlands, Suite 200, Beachwood, OH, USA; E-Mail: geriatrics@lidsen.comOBM Geriatrics 2022, volume 6, issue 2 doi:10.21926/obm.geriatr.2202199Received: June 01, 2022Accepted: June 02, 2022Published: June 09, 2022

Open Access Review

Omega-3 Long-Chain Polyunsaturated Fatty Acids in the Elderly: A Review

Received: 28 February 2022;  Published: 19 May 2022;  doi: 10.21926/obm.geriatr.2202198

Abstract

The omega-3 long-chain polyunsaturated fatty acids (omega-3 LC-PUFAs) family includes eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA). Although seafood is the richest source of omega-3 LC-PUFAs, because diet alone is often insufficient in older people, they may require food supplements and enriched food as source [...]

Open Access Review

Take a Seat for Yoga with Seniors: A Scoping Review

Received: 07 October 2021;  Published: 16 May 2022;  doi: 10.21926/obm.geriatr.2202197

Abstract

Chair yoga is a specific form of yoga practiced while seated on a chair, or standing using a chair for support; this adaptation allows those with impaired standing ability to practice safely. The purpose of this scoping review was to analyze the published literature regarding the use of chair/adapted yoga with older adults. Two researchers performed [...]

Open Access Research Article

Mammalian MutY Homolog (MYH or MUTYH) is Critical for Telomere Integrity under Oxidative Stress

Received: 22 July 2021;  Published: 02 April 2022;  doi: 10.21926/obm.geriatr.2202196

Abstract

Telomeres consist of special features and proteins to protect the ends of each chromosome from deterioration and fusion. The telomeric DNA repeats are highly susceptible to oxidative damage that can accelerate telomere shortening and affect telomere integrity. Several DNA repair factors including MYH/MUTYH DNA glycosylase, its interacting partners Rad9 [...]

Open Access Review

Living in an Age of Longevity: Enduring Insights and Perspectives for Embarking on a Quest for Health and Well-Being in Later Life

Received: 01 August 2021;  Published: 15 March 2022;  doi: 10.21926/obm.geriatr.2201195

Abstract

While increases in life expectancy along with extended longevity can be seen as a success story, there remains the central issue surrounding the health and quality of life for increasing numbers of older people. As populations live longer the idea that older people should be empowered to remain active and productive citizens will be paramount. Questions [...]

Open Access Original Research

Left Atrial Systolic Force in Hypertensive Patients with Left Ventricular Hypertrophy: A Predictor of Incident Atrial Fibrillation. The LIFE Study

Received: 20 December 2021;  Published: 09 March 2022;  doi: 10.21926/obm.geriatr.2201194

Abstract

It remains unknown whether left atrial systolic force (LASF), a measure of left atrial function, can be used as a predictor of new-onset atrial fibrillation (NOAF). Furthermore, the effect of the treatment with atenolol and losartan on LASF is unclear. A total of 758 patients without atrial fibrillation at baseline were enrolled from the Losartan Interv [...]

Open Access Original Research

The CITIDEMAGE Study: Combined Treatment with a Cholinergic Precursor in Dementia Patients

Received: 12 September 2021;  Published: 08 March 2022;  doi: 10.21926/obm.geriatr.2201193

Abstract

Certain previous studies have demonstrated the benefits of the addition of citicoline, a cholinergic precursor, to acetylcholinesterase inhibitors (AchEIs) or memantine in patients with Alzheimer’s disease (AD). The present study showed the effectiveness of oral citicoline plus AchEIs plus memantine in outpatients with AD. This was a retrospective [...]

Open Access Original Research

The Role of General Medicine in the Evaluation of Frailty in the Elderly Population: Definition of a Standardized Instrument for the Correct Framing of Frailty and Comparison with Currently Existing Instruments for Stratification of Clinical Risk

Received: 08 September 2021;  Published: 04 March 2022;  doi: 10.21926/obm.geriatr.2201192

Abstract

Frailty is a chronic condition that increases the vulnerability to stressogenic factors and prevents the patient from returning to the preceding condition of homeostasis. This increases the risk of negative outcomes and progressively brings the patient toward disability, leading to higher use of healthcare resources. Clinical risk stratification systems [...]

Open Access Review

Kampo Medicine for Older People: A Review

Received: 12 January 2022;  Published: 28 February 2022;  doi: 10.21926/obm.geriatr.2201191

Abstract

Several countries have entered the super-aging era. In Japan, the recently reported average life expectancy is approximately 90 years. Kampo medicine (a form of traditional Japanese medicine) is a part of the official medical service in Japan and is widely used for treating various illnesses of older people. However, although general physicians often [...]

Open Access Research Article

Factors Determining Subjective Health Perception Among Middle-and Upper-Middle Aged Individuals

Received: 15 October 2021;  Published: 24 February 2022;  doi: 10.21926/obm.geriatr.2201190

Abstract

In the present study, we identified the factors of cognitive and physical performances predicting self-rated health perception (SRH) using an SRH questionnaire in 660 (298 men and 362 women) upper-middle-aged community dwellers. In addition, neuropsychological test battery and physical ability tests were applied. A multiple regression analysis was condu [...]

Open Access Original Research

A Point System Table to Estimate the Risk of Cardiovascular Events in Patients with Hypertension and Left Ventricular Hypertrophy: The LIFE Study

Received: 30 December 2021;  Published: 24 February 2022;  doi: 10.21926/obm.geriatr.2201189

Abstract

We aimed to assess some readily available patient characteristics such as urinary albumin excretion as predictors of a primary composite event of myocardial infarction, cerebral stroke, and cardiovascular death among patients with hypertension and left ventricular hypertrophy, and develop risk algorithms for the outcomes. A “Cox proportional hazards [...]

Open Access Original Research

Cognitive and Physical Indicators of Gait Speed in the Community-dwelling Older Adult

Received: 16 November 2021;  Published: 15 February 2022;  doi: 10.21926/obm.geriatr.2201188

Abstract

Gait speed has been correlated to quality of life and has been called the sixth vital sign. The purpose of this study was to understand the factors that comprise fast and comfortable gait speed. 90 older adults provided demographic, cognitive, and functional performance data. Hierarchical linear regression models revealed predictors for comfortable [...]

Open Access Short Report

The COVID-19 Geropsychiatry Rounds: A Curriculum for Healthcare Providers

Received: 26 November 2021;  Published: 24 January 2022;  doi: 10.21926/obm.geriatr.2201187

Abstract

Older adults’ mental health needs significantly increased during the COVID-19 pandemic. Geriatric psychiatry is an area of extreme workforce shortage globally. A novel curriculum was developed to educate healthcare providers on COVID-19-related geriatric and geropsychiatry topics. Monthly lectures were presented from November 2020 to June 2021. Evalua [...]

Open Access Editorial

Acknowledgement to Reviewers of OBM Geriatrics in 2021

Received: 06 January 2022;  Published: 06 January 2022;  doi: 10.21926/obm.geriatr.2201186

Abstract

The editors of OBM Geriatrics would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2021. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication [...]

Open Access Original Research

Adjustment for Covariates of Major Depressive Episodes among Men and Women Aged 65 Years Old and Older

Received: 17 August 2021;  Published: 22 December 2021;  doi: 10.21926/obm.geriatr.2104185

Abstract

The current study aimed to examine if sex can significantly predict risk for lifetime major depressive episodes among adults aged 65 and older with and without adjustment for covariate variables of race, education, marital status, health, and poverty. Secondary data was obtained from the National Survey on Drug Use and Health public-use data file to [...]

Open Access Research Article

The Safety of Oral Telomerase Activator in UV-Induced Skin Cancer with A Review of Telomerase in Aging and Skin Carcinogenesis

Received: 29 July 2021;  Published: 13 December 2021;  doi: 10.21926/obm.geriatr.2104184

Abstract

The supplement telomerase activator TA-65 (purified from Astragalus membranaceus) has been shown to retard cellular senescence, boost the aging immune system, and retard age-related symptoms. Lengthened telomeres retard aging, but because cancers often maintain longevity by lengthening telomeres, dietary telomerase activator might possibly increase [...]

Open Access Original Research

Cisplatin-Based Neoadjuvant Chemotherapy for Elderly Patients with Muscle-Invasive Bladder Cancer: Is It Feasible?

Received: 23 July 2021;  Published: 08 November 2021;  doi: 10.21926/obm.geriatr.2104183

Abstract

Cisplatin-based neoadjuvant chemotherapy (C-NAC) has been the standard of care in localized muscle-invasive bladder cancer (MIBC). However, the feasibility and benefit of C-NAC in elderly patients remain uncertain since this population has always been underrepresented in pivotal trials and is often barred from chemotherapy in routine practice because [...]

Open Access Original Research

Men's Bones Matter Too, a Cross Sectional Study Examining Bone Health among Men with Intellectual Disability in Ireland.

Received: 23 June 2021;  Published: 08 November 2021;  doi: 10.21926/obm.geriatr.2104182

Abstract

Globally between 30-40% of all osteoporotic fractures occur among men, with a quarter of all hip fractures, the most serious complication of osteoporosis, occurring in men. Among men of 50 years of age or older, osteoporotic fracture risk reaches an alarming 20%. What is of great concern is that associated mortality is greater among men when compared [...]

Open Access Review

An Overview of Osteoporosis Management

Received: 28 June 2021;  Published: 19 October 2021;  doi: 10.21926/obm.geriatr.2104181

Abstract

Osteoporosis is one of the most common disorders around the world. Osteoporotic fracture especially hip fracture are associated with an increased mortality rate in elders. However, elders with osteoporosis or at high risk of fractures remain largely underdiagnosed and undertreated. The screening, diagnosis, and treatment of osteoporosis must be improved [...]

2nd Mediterranean Congress of Anti-aging Medicine 2022

14–16 October 2022, Larnaca, Cyprus

This is the second time a conference with such a wide-ranging theme on aging is held in Cyprus. The 1st Mediterranean Congress of Antiaging Medicine was held in Larnaca on 13-14 April 2019. The health of older people is a crucial subject which involves a multidisciplinary approach in order to offer effective treatments against age-related diseases. The conference is comprehensive and practical, involving both basic science and clinical therapies. Lectures, presentations and seminars will be delivered by world-class academics, and by clinicians of European prestige. It will be attended by scientists working in the science of aging both from Cyprus and from Europe, Israel, Russia, United Kingdom, as well as clinicians, health professionals and others with interest in applied, effective interventions which may help reduce the impact of aging upon society. We expect wide media coverage as well as publicity reaching European, Asian and American countries.

For more information, visit the official website at: https://mcamcyprus.org/

26th World Congress on Medical Law

December 5th- 7th, 2022, Gold Coast, Australia

The purpose of the WAML is to encourage the study and discussion of health law, legal medicine and ethics, for the benefit of society and the advancement of human rights. The aim of the WAML is to promote the study of the consequences in jurisprudence, legislation and ethics of developments in medicine, health care and related sciences.

Congress Themes:

   1. Impact of Covid on Legal Medicine

   2. Medicine and technology

   3. Concussion and Traumatic brain injury

For more details, please visit: http://wafml.memberlodge.org/, http://lidsen.com/2022 WCML Brochure FINAL.

World CB & CDx 2022

April 27-28, 2022, London, UK

As the precision medicine industry witnesses exciting Drug-Dx approvals being driven by major advancements in biomarker development, the 12th Clinical Biomarker & CDx Summit Europe returns in 2022 to set the stage for key learnings with exclusive data to optimise your drug development programmes with the most cutting-edge tools and techniques from start to finish.

Against the backdrop of complex IVDR changes creating industry-wide uncertainty, CB & CDx Europe returns at an all-important moment in time as Europe’s only end-to-end clinical biomarker and CDx summit. Uniting the entire value chain of precision medicine leaders, here you can find the latest updates, intelligence and clarity to overcome your portfolio planning hurdles.

Delving deep into the most ground-breaking work enabling patient population identification, and pairing this with revelations from streamlined commercial strategies, this is an industry poised to gain actionable insights maximising access to game-changing precision medicines and testing technology in European markets.

Join with 300+ major stakeholders of the European drug-diagnostics field to forge successful scientific and commercialization co-development strategies at a pivotal moment for precision medicine.

For more details, please visit: https://cdx-europe.com/

Alzheimer's Association International Conference

July 31 – August 4, 2022, San Diego, USA and Online

Join us in San Diego and online for AAIC 2022, where the world’s leading basic scientists, clinical researchers, early career investigators, clinicians and the care research community will share breaking research discoveries that will lead to methods of prevention and treatment and improvements in diagnosis for Alzheimer’s disease.
For more details, please visit: https://www.alz.org/aaic/overview.asp

International Continence Society

September 07-10, 2022, Vienna, Australia

What to Expect at ICS 2022

ICS 2022 in Vienna will be a great 4-day meeting, offering a range of sessions and topics depending upon your speciality and interests.

The ICS annual meeting brings together the most renowned international experts in the research and the treatment of LUTS, incontinence and pelvic foor disorders. The meeting is multidisciplinary and welcomes urologists, gynaecologists, neurourologists, physiotherapists, nurses, midwives and research scientists.

ICS 2022 State of the Art Lectures and Round Table Debates

Expect to hear from world class leaders in the field of incontinence. Their lectures and discussions will bring you the cutting-edge information about pelvic floor dysfunction. We are pleased to confirm our 2022 State of the Art Lectures.

For more details, please visit:https://www.ics.org/2022

13th Clinical Trials on Alzheimer's Disease (CTAD)

November 4-7, 2020, Boston, USA

The development of the next generation of Alzheimer’s disease treatments is among the most important health needs worldwide, but presents huge challenges. The goal of the meeting is to bring together today’s worldwide leaders in the treatment of Alzheimer’s disease to discuss new results, candidate therapeutics, and methodological issues important to the development of the next generation of Alzheimer’s disease treatments.

Clinical trial teams from worldwide centers will report on their efforts to identify new biomarkers of disease as well as more sensitive clinical assessment tools to identify those at risk for AD, to predict progression, and assess the effectiveness of new treatments.

For more details, please visit: https://www.ctad-alzheimer.com/ctad-2020

Alzheimer's Association International Conference®

July 26-30, 2020, Amsterdam, Netherlands

AAIC 2020 will bring together international investigators, clinicians and care researchers to discuss the latest studies, theories and discoveries that will help bring the world closer to breakthroughs in dementia science.

For more details, please visit: https://www.alz.org/aaic/overview.asp

Integrative Regen Group

February 29- March 2, 2020, Arizona Biltmore Resort, USA

Who: Providers of all disciplines who are passionate about or interested in regenerative medicine are encouraged to attend this event. The agenda will be packed full of actionable topics that most attendees will be able to put into effect immediately to continue to provide their patients with the most cutting-edge therapies.

What: Integrative Regen Group’s second conference will be bringing together experts in all areas of regenerative medicine, from stem cells to photobiomodulation, peptides to hormones, and everything in between. It is our goal that every person in attendance increase their knowledge base substantially.

For more details, please visit: https://www.intregengroup.com/

The 2nd Longevity Therapeutics

January 28-30, 2020, San Francisco CA, USA

With rapid advances in the understanding of the underlying biology and mechanisms of aging, ground-breaking research and technology are coming together to target aging pathways, in a way to prevent, reverse or delay the onset of age-related conditions, and consequently improve heathspan.

The 2nd Longevity Therapeutics 2020 Summit will once again bring together 80+ leading experts in aging-related research, including biotechs, pharma, academics and investors, who are committed to serving worldwide population with innovative drugs to prevent, delay and treat age-related conditions.

For more details, please visit: https://longevity-therapeutics.com/

OBM Geriatrics welcomes the following types of articles: original research, review, communication, opinion, case report, comment, conference report, technical note, book review, etc. There is no restriction on the length of the papers, color figures, supplementary file types. More details please see Instructions for Authors.

Register and Submit now.

Announcement
Newsletter
Highlight

Highlight

by Michael Fossel

OBM Geriatrics 2022

Published: 15 January 2020

Highlight from: A unified model of dementias and age‐related neurodegeneration.

Michael Fossel.

Alzheimer’s & Dementia.

doi: 10.1002/alz.12012.

Highly Accessed Articles

Case Report

by Garuth Chalfont et al.

OBM Geriatrics 2022

Published: 07 August 2019

Perspective

by Robert Conder et al.

OBM Geriatrics 2022

Published: 20 March 2019

Review

by Michael Fossel

OBM Geriatrics 2022

Published: 15 February 2019

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