Open Access Original Research

Detection of Activated Pepsin in Bronchoalveolar Lavage and Acute Cellular Rejection in Lung Transplant Recipients

Received: 23 February 2024;  Published: 21 June 2024;  doi: 10.21926/obm.transplant.2402219


Activated pepsin (pepA) in bronchoalveolar lavage (BAL) fluid may be a biomarker of gastric aspiration. We sought to i) evaluate the association of pepA in BAL fluid with acute cellular rejection (ACR) in a cohort of lung transplant recipients (LTRs), ii) assess the association between pepA and isolation of typical gastrointestinal microorganisms from [...]

Open Access Case Report

Art of Telesupport of Caregiver during Myasthenia Gravis Crisis by COVID-19 Infection-Related Followed by Rescue in Late-Onset Patient

Received: 06 February 2024;  Published: 21 June 2024;  doi: 10.21926/obm.icm.2402035


An 83-year-old man with myasthenia gravis was hospitalized in the ICU; support for caregivers of elderly myasthenic patients in the ICU can be a crucial aspect of their care. Myasthenia gravis is a chronic autoimmune neuromuscular disease that can cause varying levels of muscle weakness, which can significantly impact the patient's day-to-day activities [...]

Open Access Review

Investigating the Genetic Basis of Unexplained Infertility and Potential Chromosomal Abnormalities

Received: 24 March 2024;  Published: 20 June 2024;  doi: 10.21926/obm.genet.2402246


Infertility affects millions globally, with 10-15% of couples experiencing unexplained cases. Despite advancements in medicine, the cause remains unknown, causing emotional distress. Recent research suggests a genetic basis for this issue. This review aims to provide a better understanding of the underlying genetic factors contributing to unexplained [...]

Open Access Original Research

Physico-Chemical Study of the Anti-Diabetic Drug of [BzN-EJJ-amide] for Treatment Type2 Diabetes Using CNT Sensor by Drug Delivery Method

Received: 22 February 2024;  Published: 19 June 2024;  doi: 10.21926/obm.genet.2402245


The potential and selective inhibitors of protein tyrosine phosphatase 1B (PTP1B) are therapeutically useful in treating type 2 diabetes. N-Benzoyl-L-glutamyl-[4-phosphono(difluoromethyl)]-L-phenylalanine-[4-phosphono(difluoro-methyl)]-L-phenylalanineamide (BzN-EJJ-amide) (BGD) which is the ligand of 1LQF protein code extracted from protein data bank [...]

Open Access Original Research

The Effect of Rake Angle and Cutting Edge Radius on the Orthogonal Cutting Process of Ti6Al4V Alloy

Received: 23 February 2024;  Published: 18 June 2024;  doi: 10.21926/rpm.2402013


This paper investigates the effect of rake angle, α, cutting edge radius, r, and feed rate, f, on the cutting force and cutting zone temperature during orthogonal dry cutting of Ti6Al4V. A numerical model representative of the 2D orthogonal cutting process is developed using ABAQUS/Explicit software. Johnson-Cook, (JC) constitutive material model is [...]

Open Access Original Research

Establishment of an In Vitro Propagation, Transformation, and Gene Editing System in Tomato (Solanum lycopersicum)

Received: 12 January 2024;  Published: 18 June 2024;  doi: 10.21926/obm.genet.2402244


Tomato (Solanum lycopersicum), a family of Solanaceae, is an annual crop grown in fields and greenhouses. Tomato is the fourth-largest agricultural crop in the world, with a market value of more than $50 billion. Numerous attempts were conducted on the tomato for further improvement via in vitro regeneration and transformation. This study aims to establ [...]

Open Access Review

The Effectiveness of Using Progressive Muscle Relaxation Techniques on Quality of Life, Stress, And Anxiety Among Acute Myocardial Infarction: A Systematic Review

Received: 28 February 2024;  Published: 16 June 2024;  doi: 10.21926/obm.neurobiol.2402226


The progressive muscle relaxation technique (PMRT) is an active method that is defined as a technique through which individuals gradually cause a feeling of quietness and coolness by actively contracting and loosening specific muscle groups. The purpose of this study was to review the effectiveness of using progressive muscle relaxation techniques on [...]

Open Access Original Research

Integrated Web Application (Snips2HLA-HsG) Development for Sample Preparation and Model Creation for HLA Allele Prediction with the SNP Data Using HIBAG Package of Bioconductor and R Programming

Received: 24 December 2023;  Published: 14 June 2024;  doi: 10.21926/obm.genet.2402243


The present study introduces Snips2HLA-HsG, an integrated application designed for SNP genotype analysis and HLA allele type prediction. Leveraging attribute bagging, a powerful ensemble classifier technique from the Bioconductor HIBAG package, Snips2HLA-HsG offers a comprehensive response for genetic analysis. Accessible via https://snips2hla.shin [...]

Open Access Review

llmenite and Biomass Composite Nanomaterials - A Review

Received: 10 April 2024;  Published: 13 June 2024;  doi: 10.21926/cr.2402006


Ilmenite is a mineral whose crystallinity can be altered by chemical treatment, producing TiO2 and iron and titanium-based metal nanocomposites, which are applicable mainly for photocatalysis. Porous and crystalline biomass-derived carbon materials include graphene oxide, reduced graphene oxide, graphitic carbon nitride, catalytically graphitized sucros [...]

Open Access Short Communication

Therapeutic Termination of Pregnancy and Paternal Mental Outcomes

Received: 26 December 2023;  Published: 13 June 2024;  doi: 10.21926/obm.icm.2402034


Therapeutic termination of pregnancy (TToP) is performed for maternal health risks or severe fetal malformations. Research focuses on women's psychopathological outcomes after TToP, noting that 10-22% of women experience psychiatric disorders, especially depressive symptoms and post-traumatic stress disorder (PTSD). However, little is known about patern [...]

Open Access Review

Melatonin As a Protective Agent Against Environmental Stresses: A Review into Its Molecular Regulation in Plants

Received: 05 February 2024;  Published: 12 June 2024;  doi: 10.21926/obm.genet.2402242


Understanding the impact of melatonin (N-acetyl-5-methoxytryptamine) on plant gene expression is crucial for unlocking its full potential as a tool for crop improvement and stress tolerance. Melatonin has emerged to have several influences on the transcriptional activity of numerous genes, helping to orchestrate plant responses to environmental cues [...]

Open Access Original Research

The Screening Strategies Used to Establish Egyptian Women Entrepreneurs’ Attitudes towards Genetic Technology

Received: 12 March 2024;  Published: 12 June 2024;  doi: 10.21926/obm.genet.2402241


In this quantitative study, the researcher examined the screening strategies used to establish Egyptian women entrepreneurs' attitudes toward genetic technology. Using a questionnaire, the researcher collected data from 318 Egyptian women entrepreneurs. From applying the path analysis through Analysis of Moment Structures (AMOS) version 26.0, this stud [...]

Open Access Review

Phytoremediation: A Sustainable Approach to Combat Soil Salinity

Received: 14 March 2024;  Published: 12 June 2024;  doi: 10.21926/aeer.2402015


Soil salinization is a significantconstraint affecting the productivity of agricultural land worldwide. This led to the abandoning of the production of farmcrops on colossalland. Soil salinity inversely affects seed germination and plant growth and influences the plant’s biological activities like photosynthesis, respiration, plant metabolism, en [...]

Open Access Research Article

Developing a Compassion Focused Supervision Model for Senior Leaders in Education

Received: 22 March 2024;  Published: 11 June 2024;  doi: 10.21926/obm.icm.2402033


This article describes the development and delivery of a novel model of supervision for senior teachers in schools, informed by Compassion Focused Therapy (CFT). It explores whether this model can be considered acceptable and valuable to senior teachers, and is able to be delivered by multiple supervisors using a manual. Surveys, interviews, and focus [...]

Open Access Original Research

Molecular Cytogenetic Characterization of Rare but Repeatedly Observed Translocations

Received: 15 April 2024;  Published: 11 June 2024;  doi: 10.21926/obm.genet.2402240


Balanced chromosomal rearrangements, including translocations, contribute to infertility, repeated abortions, and/or genetically imbalanced offspring in corresponding carriers. A translocation is usually considered a unique, de novo, or familial event. Besides, some translocations have also been shown to develop multiple times with slightly different [...]

Open Access Review

Human Health Impact of Municipal Solid Waste Mismanagement: A Review

Received: 22 December 2023;  Published: 11 June 2024;  doi: 10.21926/aeer.2402014


Management of municipal solid waste (MSW) is frequently not properly performed. Whenever this happens, those working in the different stages of the process, as well as residents close to the dumps, face health risks. Here, we revised the documented evidence of emissions liberated during MSW management and associated health problems to investigate if [...]

Open Access Case Report

Management of Calcareous Corneal Degeneration from Medication Washout to Corneal Transplantation. Case Series and Review of the Literature

Received: 27 February 2024;  Published: 07 June 2024;  doi: 10.21926/obm.transplant.2402218


Calcareous corneal degeneration is a rare disease characterized by calcium phosphate deposition into the deep corneal layers. Corneal calcification has a multifactorial origin and is associated with various systemic and ocular conditions. Several treatment options showed promising results in the management of this disorder. Herein, two cases of calcareo [...]

Open Access Original Research

Prescribed Medicinal Cannabis for the Treatment of Chronic Pain Comorbid with Depression: Real World Evidence from Project Twenty21

Received: 01 March 2024;  Published: 05 June 2024;  doi: 10.21926/obm.icm.2402032


Chronic pain is one of the most common conditions for which people seek treatment with cannabis-based medicinal products (CBMPs) and there is mounting real world evidence that CBMPs are safe and effective in treating pain. Many people with chronic pain also experience major depression and it is unknown whether pain patients with major depression derive [...]

Open Access Original Research

Circulating lncRNAs HOTTIP and HOTAIR as Potential Biomarkers in Crigler-Najjar Syndrome: A Preliminary Report from Shiraz Liver Transplant Research Center

Received: 05 May 2024;  Published: 04 June 2024;  doi: 10.21926/obm.transplant.2402217


Crigler-Najjar syndrome (CNS) is a rare autosomal recessive disorder characterized by impaired bilirubin metabolism, leading to neurotoxic unconjugated bilirubin accumulation. Liver transplantation remains the only effective treatment, highlighting the need for novel diagnostic and therapeutic approaches. Long non-coding RNAs (lncRNAs) have emerged [...]

Open Access Original Research

Is Stimulant Treatment in Children and Adolescents with Mood Dysregulation Associated with Adverse Outcomes?

Received: 25 January 2024;  Published: 04 June 2024;  doi: 10.21926/obm.icm.2402031


The aim of this paper is to examine effects of stimulant treatment in children and adolescents with high levels of emotional dysregulation in a psychiatric outpatient clinic. Subjects were referred children and adolescents 6-17 years of age who presented to a child psychiatric outpatient clinic between September 2016-November 2021 and received a prescri [...]

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