Open Access Original Research

Tacrolimus Therapeutic Response, Pharmacokinetics and Adherence in Liver Transplant Recipients

by Mouna Daldoul  , Rim Charfi  , Khouloud Ferchichi  , Mouna Ben Sassi  , Syrine Ben Hammamia  , Fatma Medhioub  , Emna Gaies  , Rym Enneifer  , Hanene Eljebari  , Anis Klouz  , Riadh Daghfous  and Sameh Trabelsi

Received: 20 August 2024;  Published: 13 December 2024;  doi: 10.21926/obm.transplant.2404228

Abstract

Background: Tacrolimus is characterized by a high intra and interindividual pharmacokinetics variability. Data regarding factors that may influence its pharmacokinetics and pharmacodynamics in liver transplantation are limited. The objectives of this study were to assess tacrolimus therapeutic respo [...]

46 327

Open Access Original Research

A Phase I/II Randomized Trial of Higher Dose mRNA-1273 Boosters in Lung Transplant Recipients

by Michael Y. Shino  , Francisco Javier Ibarrondo  , Jesse L. Clark  , Adreanne Rivera  , Marlene Florian  , Allison Ramsey  , Ariss Derhovanessian  , Rajan Saggar  , Olawale O. Amubieya  , Grant Turner  , Joanna M. Schaenman  , Pryce T. Gaynor  , Omer E. Beaird  , Ashrit Multani  , Reshma M. Biniwale  , Murray H. Kwon  , Christos J. Petropoulos  , Yolanda Lie  , Terri Wrin  , Amparo L. Figueroa  , Brett Leav  , Zelalem Endale  , Kate Anteyi  , Jacqueline M. Miller  , Abbas Ardehali  , David M. Sayah  , David Elashoff  , John A. Belperio  , Otto O. Yang  and S. Sam Weigt

Received: 16 August 2024;  Published: 20 November 2024;  doi: 10.21926/obm.transplant.2404227

Abstract

Higher-dose mRNA booster vaccines have not been well studied for transplant recipients. This study evaluated the safety, reactogenicity and immunogenicity of higher dose mRNA-1273 booster vaccines among lung transplant recipients (LTRs). This phase 1/2 open-label randomized clinical trial of higher- [...]

96 656

Open Access Research Article

Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Fanconi Anemia: Results of a Single Center with a Fludarabine-Based Conditioning Regimen

by Sabrine Mekni  , Lamia Torjemane  , Malek Khayati  , Dorra Belloumi  , Rimmel Yosra Kanoun  , Insaf Ben Yaiche  , Rihab Ouerghi  , Ines Turki  , Saloua Ladeb  , Tarek Ben Othman  and Nour Ben Abdeljelil

Received: 29 June 2024;  Published: 11 November 2024;  doi: 10.21926/obm.transplant.2404226

Abstract

Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) remains the only curative treatment for bone marrow failure (BMF) and hematologic complications of Fanconi anemia (FA). The evolution remains affected by the toxicity, the risk of graft failure, and clonal evolution. This stu [...]

104 689

Open Access Case Report

Use of Plasma-Rich in Growth Factors (PRGF) in the Treatment of Acne

by Elga J. Vargas  , Julio C. Martinez  and Lina A. Gomez

Received: 26 April 2024;  Published: 03 October 2024;  doi: 10.21926/obm.transplant.2404225

Abstract

Acne is a chronic inflammatory condition affecting the pilosebaceous units of the skin, characterized by the formation of papules, cysts, comedones, pustules, nodules, and scars. These lesions are typically located on the face and shoulders, although they can extend to the trunk, arms, and legs. In [...]

161 1049

Open Access Review

Current and Future Applications of Machine Perfusion and Other Dynamic Preservation Strategies in Liver Transplantation

by Yue Qiu  , Yinqian Kang  , Hao Liu  and Ibtesam Hilmi

Received: 12 May 2024;  Published: 30 August 2024;  doi: 10.21926/obm.transplant.2403224

Abstract

Machine perfusion (MP) techniques, which simulate physiological conditions to allow for the assessment and preservation of organ viability, are currently applied in various solid organ transplantation fields. Owing to the growing demand for liver transplants and [...]

154 1467

Open Access Review

Platelets as Regenerative Cells, Hundreds of Opportunities in Sight

by Elga Johanna Vargas  , Ana Luisa Muñoz  and Lina Andrea Gómez

Received: 21 May 2024;  Published: 13 August 2024;  doi: 10.21926/obm.transplant.2403223

Abstract

Platelets were the last to be discovered of the three formed blood elements. Several scientists have been interested in them, recognizing them as cells other than leukocytes and erythrocytes. Its job in hemostasis and thrombosis is currently known. Platelets contain growth factors and secrete cytoki [...]

123 1147

Open Access Review

Machine Perfusion of Donor Hearts – The Recovery and Transplantation of Previously Unrecoverable Hearts

by Sanjay Dutta  , Jeanette E. Villanueva  , Yashutosh Joshi  , Ling Gao  , Paul Jansz  and Peter S. Macdonald

Received: 02 April 2024;  Published: 05 August 2024;  doi: 10.21926/obm.transplant.2403222

Abstract

Heart transplantation remains the gold standard treatment for end-stage heart failure. With an increasing population and improving medical therapy there is an increasing number of patients who would benefit from heart transplantation but are unable to receive one due to a shortage of sui [...]

178 1488

Open Access Review

BK Virus-Associated Nephropathy in Adult Patients Post Kidney Transplantation: What Progress in 30 Years of History?

by Yassamine Bentata

Received: 24 January 2024;  Published: 25 July 2024;  doi: 10.21926/obm.transplant.2403221

Abstract

Completely unknown before the 90s and exceptional up to the 2000s, BK virus nephropathy (BKvN), usually known as polyomavirus-associated nephropathy, has emerged as a significant and severe viral complication in kidney transplantation (KT). More than twenty years after Gardner's discovery of BKv in [...]

200 1599

Open Access Research Article

Impact of Intravenous Immunoglobulin Replacement Therapy on Hypogammaglobulinemia and Infection in Lung Transplant Recipients

by Van Anh Vu  , Joelle Nelson  , Helen Sweiss  , Reed Hall  , Holly Keyt  and Elisabeth Kincaide

Received: 29 January 2024;  Published: 03 July 2024;  doi: 10.21926/obm.transplant.2403220

Abstract

Secondary hypogammaglobulinemia (HGG) from immunosuppression therapy in lung transplant recipients has been associated with increased mortality, morbidity and higher risk of infection. Intravenous immunoglobulin (IVIG) for the treatment of HGG post-lung transplant is not well studied wit [...]

194 1655

Open Access Original Research

Detection of Activated Pepsin in Bronchoalveolar Lavage and Acute Cellular Rejection in Lung Transplant Recipients

by Andrés R. Latorre-Rodríguez  , Devika Sindu  , Sumeet K. Mittal  and Ashwini Arjuna

Received: 23 February 2024;  Published: 21 June 2024;  doi: 10.21926/obm.transplant.2402219

Abstract

Activated pepsin (pepA) in bronchoalveolar lavage (BAL) fluid may be a biomarker of gastric aspiration. We sought to i) evaluate the association of pepA in BAL fluid with acute cellular rejection (ACR) in a cohort of lung transplant recipients (LTRs), ii)&l [...]