by Subhranshu Sekhar Kar  , Rajani Dube  , Biji Thomas George  and Malay Jhancy

Received: 07 April 2024;  Published: 20 December 2024;  doi: 10.21926/obm.genet.2404276

There is a high prevalence of genetic abnormalities that significantly contribute to overall morbidity and mortality in neonates. Since early diagnosis is crucial for the optimal administration of conventional and customized medications, neonatal acute care has the most significant potential to benefit from genomic medicine. Genome sequencing has been demonstrated to have diagnostic, therapeutic and informational value in many investigations. With underlying genetic disorders, genome sequencing has the power to cha [...]

by Elham Amjad  , Babak Sokouti  , Solmaz Asnaashari  and Siavoush Dastmalchi

Received: 29 August 2024;  Published: 17 December 2024;  doi: 10.21926/obm.genet.2404275

This systematic review examines the role of SnRK2 (Sucrose non-fermenting 1-Related protein Kinase 2) genes in Arabidopsis thaliana growth and responses to abiotic stresses. SnRK2 protein kinases are key components of abscisic acid (ABA) signaling and osmotic stress responses in plants. The review synthesizes findings from numerous studies on how different SnRK2 genes regulate Arabidopsis growth, development, and stress tolerance at various life stages. Key topics covered include SnRK2 functions under environmental [...]

by Aileen M. Lynch  , Gabrielle McKee  , Fintan Sheerin  , Jean-Luc Bosson  , Monique Epstein  , Ariane Girault  , Carole Rolland  , Mary Harkin  , Ciaran McKinney  and Pierre Gillois

Received: 05 June 2024;  Published: 17 December 2024;  doi: 10.21926/obm.geriatr.2404292

While the facilitators/barriers for the initiation of physical activity (PA) are well documented, there is less known about these facilitators/barriers for maintenance of PA in the older population in general and not following an intervention. This study aimed to explore older adults’ perspectives on the facilitators/barriers to maintaining PA. The study used a descriptive qualitative design, with three focus groups, one in Ireland and two in France. Participants were community-dwelling older adults (≥60 years) 66% [...]

by Jared Tucker  and Victor Lai

Received: 28 June 2024;  Published: 17 December 2024;  doi: 10.21926/rpm.2404028

Many cells demonstrate variances in behavior due to their cell culture environment. To provide a mechanically-tunable, tissue-like environment, a 3D hydrogel for cell culture was formulated using collagen (Col) and hyaluronic acid (HA) to help provide a system for studying these dynamic cellular responses in a soft-tissue environment. A design of experiments was organized to study the effects of collagen concentration, HA fragment size, and Col: HA mass ratio on the hydrogel mechanical properties. Mechanical charac [...]

by Mouna Daldoul  , Rim Charfi  , Khouloud Ferchichi  , Mouna Ben Sassi  , Syrine Ben Hammamia  , Fatma Medhioub  , Emna Gaies  , Rym Enneifer  , Hanene Eljebari  , Anis Klouz  , Riadh Daghfous  and Sameh Trabelsi

Received: 20 August 2024;  Published: 13 December 2024;  doi: 10.21926/obm.transplant.2404228

Background: Tacrolimus is characterized by a high intra and interindividual pharmacokinetics variability. Data regarding factors that may influence its pharmacokinetics and pharmacodynamics in liver transplantation are limited. The objectives of this study were to assess tacrolimus therapeutic response, pharmacokinetics and adherence in liver transplant recipients. Methods: The study was conducted at the Clinical Pharmacology Department over a period of 12 years from January 2009 to March 2021. We included liver tr [...]

by Grace Douglas  , Andrew S Day  and Stephanie C Brown

Received: 23 August 2024;  Published: 13 December 2024;  doi: 10.21926/rpn.2404020

Dietary and nutritional interventions have been shown to have roles in managing active Crohn disease (CD), with exclusive enteral nutrition (EEN) being recommended as the preferred initial treatment in children following diagnosis. In recent years, other nutritional interventions such as the Crohn's disease exclusion diet (CDED) have been considered and evaluated for induction therapy. To date, the long-term benefits of CDED have not been established. This report highlights the outcomes of the prolonged use of CDED [...]

by Hossein Hosseinkhani

Received: 26 August 2024;  Published: 12 December 2024;  doi: 10.21926/rpm.2404027

Viral and non-viral vectors for nucleic acids (DNA/RNA) therapeutics are important in development of pharmaceutical industries. Although viral vectors have shown significant impact in transfection of DNA/RNA, but numerus studies have shown that non-viral vectors are also effective for the safe and targeted delivery of DNA/RNA to exact location in the body with high percentage of efficacy, safety, and low-immunogenicity. It is also important to protect the nucleic acids from degradation and large-scale production ca [...]

by Özlem Özbek

Received: 16 June 2024;  Published: 12 December 2024;  doi: 10.21926/obm.genet.2404274

Genetic diversity allows plants to adapt to changing environmental conditions to survive and increases their ability to respond to yield, production, pests and diseases. The application of molecular markers developed due to developments in biochemistry, molecular biology, and plant technology has shed light on plant genetics and breeding studies and produced an enormous amount of knowledge. The theoretical knowledge will guide in determining the scope, amount, and distribution of different aspects of genetic divers [...]

by Alastair C. Gray  , Parker Pracjek  , Christine D. Luketic  and Denise Straiges

Received: 03 September 2024;  Published: 09 December 2024;  doi: 10.21926/obm.icm.2404069

Research into the uptake profile and usage of Homeopathy has hitherto tended to be buried amongst complementary medicine research. Despite high levels of uptake of homeopathy, and robust numbers of over-the-counter sales of homeopathic products the current evidence evaluating the uptake of homeopathy remains limited on several fronts. The aim of this study is to explore the basic demographic features and characteristics of users of homeopathy services. The setting is a student teaching tele-health facility based in [...]

by Rebecca H. Affoo  and Ashwini Namasivayam-MacDonald

Received: 06 August 2024;  Published: 09 December 2024;  doi: 10.21926/obm.geriatr.2404291

A conceptual model was developed to create a basis for understanding the risk factors and outcomes associated with dysphagia and to hypothesize the nature of the relationship between certain factors. The conceptual model was developed by two academic speech-language pathologists with ≥10 years research and clinical experience in swallowing and dysphagia in older adults. A comprehensive review of English-language literature was conducted, and relevant, evidence-informed factors associated with dysphagia in older adu [...]