by Joseph S. D'Arrigo

Received: 27 December 2018;  Published: 17 June 2019;  doi: 10.21926/obm.geriatr.1902057

Much evidence has been published which indicates that microvascular endothelial dysfunction, due to cerebrovascular risk factors (e.g., atherosclerosis, hypertension, obesity, diabetes, smoking, aging), precedes cognitive decline in Alzheimer's disease and contributes to its pathogenesis. By incorporating appropriate drug(s) into biomimetic (lipid cubic phase) nanocarriers, one obtains a multitasking combination therapeutic which targets certain cell-surface scavenger receptors, and crosses the blood-brain barrier [...]

by Michael Chapman  , Jennifer Philip  and Paul Komesaroff

Received: 20 December 2018;  Published: 17 June 2019;  doi: 10.21926/obm.geriatr.1902056

Alzheimer’s Disease is increasingly seen as the major health in developed countries supplanting cancer and heart disease. The terror with which we respond to dementia, is grounded in a view of dementia as a monstrous descent, ambushing our healthy ageing through an incursion of pathology. The pervasiveness of this view can mean that other perspectives and even the views of those most touched by the challenges of dementia can remain unheard. Part of the cultural conversation around dementia is informed by contemp [...]

by Terence Seedsman

Received: 29 January 2019;  Published: 24 May 2019;  doi: 10.21926/obm.geriatr.1902055

The history surrounding the notion of ‘informed consent’ is provided in the interest of setting a framework for the emergence of an ethics of aged care. Informed consent negligence is seen as a breach of duty involving potential litigation through the legal concept of ‘failure to warn’. Research involving older people creates a range of ethical issues that warrants the use of best practice principles that respect the integrity, dignity and safety of older participants. The use of restraints as part of aged care is [...]

by Mamta Saxena  , Anne F. Farrell  and Kari Adamsons

Received: 25 February 2019;  Published: 20 May 2019;  doi: 10.21926/obm.geriatr.1902054

Most individuals with disabilities in the US live in family settings; in some families, siblings are default long-term support providers. Although researchers have explored the roles of parent caregivers, the roles of sibling caregivers need attention. In this study, we examined caregiving processes and outcomes among 322 adult sibling support providers (SSPs) with a range of support roles. Adapting a conceptual model of caregiving processes, we used structural equation modeling to assess relationships among percei [...]

by Karen Harrison Dening  and Zena Aldridge

Received: 26 February 2019;  Published: 10 May 2019;  doi: 10.21926/obm.geriatr.1902053

People with dementia do not exist in isolation and whilst there has been a strong thrust to identify the needs of people with dementia against a background of person centred care, they live within relational contexts with family members. Case management is a model of care that can support the care needs of both the person with dementia and the family carers through coordinating care and services that are both integrated across health and social care but also carer that is sensitive to the needs of different member [...]

by Lindy A. Kilik  and Robert W. Hopkins

Received: 01 March 2019;  Published: 09 May 2019;  doi: 10.21926/obm.geriatr.1902052

Background: Clinical studies have shown that caregivers of dementia patients often experience a great deal of stress related to caregiving. This paper examines caregiver stress within the context of behaviour change in dementia using the Kingston Caregiver Stress Scale (KCSS) and the Kingston Standardized Behaviour Scale (Community Form) (KSBA(comm)). Methods: Eighty patients with moderate dementia and their caregivers participated. Each patient was cognitively assessed with the Kingston S [...]

by Gian Andrea Rollandi  , Aldo Chiesa  , Nicoletta Sacchi  , Mauro Castagnetta  , Matteo Puntoni  , Adriana Amaro  , Barbara Banelli  and Ulrich Pfeffer

Received: 31 January 2019;  Published: 05 May 2019;  doi: 10.21926/obm.geriatr.1902051

Aging is associated with an increasing incidence of major diseases among which cancer, cardiovascular, neurodegenerative, metabolic and autoimmune diseases. Primary prevention and early diagnosis of these diseases have a dramatic impact on incidence, outcome and quality of life and are commonly applied as age-dependent indications based on evidence of efficacy for specific groups of the aging population. They likely contribute to the observed increase in life expectancy through the reduction of incidence and the re [...]

by Claire Thompson  , Daniela Calafiore  , Julijana Chochovski  , Steven Trawley  and Kathryn von Treuer

Received: 29 October 2018;  Published: 26 April 2019;  doi: 10.21926/obm.geriatr.1902050

(1) Background: The increasing numbers and proportion of the ageing population make it essential to develop and evaluate programs to meet the needs of older adults to empower them to age actively, healthily and successfully. Consequently, positive ageing programs have been developed and the need to evaluate their efficacy is essential. This study used mixed methods to evaluate a longstanding positive ageing psychoeducation program “SAGE” conducted in Australia. (2) Methods: Two approaches were utilised. The first [...]

by Michael P. Cary  , Valerie A. Smith  , Megan Shepherd-Banigan  , Jennifer H. Lindquist  , Jennifer G. Chapman  , Susan N. Hastings  and Courtney H. Van Houtven

Received: 22 February 2019;  Published: 18 April 2019;  doi: 10.21926/obm.geriatr.1902049

Background: Moderator analyses may be helpful for evaluating intervention effects. The objective of this study was to evaluate whether the effect of a caregiver skills training intervention – Helping Invested Families Improve Veterans' Experience Study (HI-FIVES) – on care recipient outcome and caregiver outcome is moderated by the veteran’s risk for hospitalization or level of functional impairment. Methods: Secondary data analysis of HI-FIVES. Outcomes included community days (cumulative days in the community at [...]

by Keith A. Wollen  and John W. Hoyt

Received: 15 February 2019;  Published: 18 April 2019;  doi: 10.21926/obm.geriatr.1902048

Abstract Background: Cognitive abilities in Alzheimer’s Disease are usually examined by formal tests conducted in a laboratory or facility. Such tests are useful for determining the severity of the disease but do not indicate the types of cognition exhibited in the daily lives of patients. This study shows cognitive preservation in daily life by a woman given multiple therapeutic interventions. Since Alzheimer’s disease involves multiple dysfunctions, several studies found multiple therapeutic approaches to be effe [...]