by Mark Jaradeh  , Mark deBettencourt  , Edgar Yap  , Yesha Patel  , April Alcantara  , Conrad Stasieluk  and Edwin S. Meresh

Received: 02 March 2022;  Published: 23 May 2022;  doi: 10.21926/obm.neurobiol.2202123

Catatonia, particularly malignant catatonia (MC), continues to manifest in severe sequalae such as hyperthermia, rhabdomyolysis, cardiovascular collapse and failure, and even death as, although identification of the syndrome has significantly improved once its developed, several precarious factors continue to inhibit prompt and efficacious treatment. In this context, we evaluated the cases of six patients who were treated at our center for eventual MC manifestation with the aim of elucidating a pre-MC sensitive pre [...]

by Igor Val Danilov  and Sandra Mihailova

Received: 24 January 2022;  Published: 18 May 2022;  doi: 10.21926/obm.neurobiol.2202122

Studies in the field of neuroscience have shown that the neural network responsible for numeracy overlaps with the visual and spatial processing regions. Other studies in psychology also highlighted an association of visual-spatial processing with mathematical competence at the early stages of development. These findings suggest that research on the size of the focal area of attention (consciousness) can contribute to understanding the development of numeracy. In this case study, we verified the hypothesis of devel [...]

by Ashley Schumaker  , Rachel Klauber  , Margaret Aasen  , Michael Padua  and Edwin Meresh

Received: 07 December 2021;  Published: 24 April 2022;  doi: 10.21926/obm.neurobiol.2202121

Catatonia and malignant catatonia may result in devastating and life-threatening complications like pulmonary embolisms, pneumonia, deep venous thrombosis, rhabdomyolysis, and even death. There have been documented cases implicating alcohol withdrawal as a significant culprit in catatonia. Here, we provide a unique case report of a patient with a complicated medical course, who subsequently developed malignant catatonia secondary to severe alcohol withdrawal, and was successfully treated using both first line treat [...]

by Joshua A Vova

Received: 21 February 2022;  Published: 20 April 2022;  doi: 10.21926/obm.neurobiol.2202120

Cerebral Palsy (CP) is the most frequent cause of childhood disability. CP occurs in 1 out of every 345 children in the United States. CP is primarily a motor disease that is the result of an insult to the brain that occurs during the prenatal or early postnatal period when the brain is still developing. CP is not a single disease but a physical description of motor impairments that originate from multiple etiologies. This article briefly discusses the etiologies, classification and management of the neurologic med [...]

by Kory Floyd  , Nathan Woo  , Benjamin Custer  , Dana Dinsmore  , Kaylin Duncan  and Jeannette Maré

Received: 07 January 2022;  Published: 19 April 2022;  doi: 10.21926/obm.neurobiol.2202119

Loneliness is a common condition that poses substantial risks to morbidity and mortality. Cacioppo and Cacioppo’s [1] evolutionary theory of loneliness (ETL) provides that loneliness serves a social signaling function and also manifests in hypervigilance to threat, which we propose can influence person perception. In this experiment, 480 observers evaluated videotaped self-presentation messages from speakers who scored either high or low on a measure of loneliness. On the basis of ETL, we hypothesized that observer [...]

by OBM Neurobiology Editorial Office

Received: 02 April 2022;  Published: 07 April 2022;  doi: 10.21926/obm.neurobiol.2202118

by Joseph S. D'Arrigo

Received: 08 December 2021;  Published: 29 March 2022;  doi: 10.21926/obm.neurobiol.2201117

Cerebrovascular atherosclerosis, and several other cardiovascular (or "inflamm-aging" type) diseases, are more frequent and advanced in subjects with Alzheimer's disease compared with normal aging. In addition, the observed pathogenic link to dementia (and its associated cerebral microvascular damage) is readily explained by alterations of arterial elasticity. A therapeutic strategy to delay dementia could be based upon localized drug delivery, using lipid nanocarriers (i.e., biobased nanoemulsion technology), targ [...]

by Najam A. Sharif

Received: 24 January 2022;  Published: 22 March 2022;  doi: 10.21926/obm.neurobiol.2201116

Glaucomatous optic neuropathy (GON) associated with different forms of glaucoma and chronic ocular hypertension (cOHT) is characterized by progressive loss of retinal ganglion cells and their axons in the optic nerves that project to the brain to transmit visual information. The resultant thinning of the optic nerves cause loss of peripheral vision, which if not halted or slowed, can lead to irreversible blindness. Whilst the precise triggering insult(s) for the primary open angle glaucoma (POAG), the most prevalen [...]

by Yasushi Shibata  , Masayuki Goto  and Sumire Ishiyama

Received: 25 October 2021;  Published: 08 February 2022;  doi: 10.21926/obm.neurobiol.2201115

Magnetic resonance imaging (MRI) has been used to investigate migraine pathophysiology because it is a non-invasive technique. The main aim of clinical imaging for patients with headaches is to exclude secondary headaches due to organic lesions. Conventional structural imaging techniques such as routine MRI demonstrate white matter lesions, changes in gray matter volume or cortical thickness, and cerebral blood flow in patients with migraine. Changes in metabolite levels are observed by magnetic resonance spectrosc [...]

by OBM Neurobiology Editorial Office

Received: 05 January 2022;  Published: 06 January 2022;  doi: 10.21926/obm.neurobiol.2201114

The editors of OBM Neurobiology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2021. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificate of recognition di [...]