by Rustam Nailevich Mustafin

Received: 10 August 2023;  Published: 31 October 2024;  doi: 10.21926/obm.neurobiol.2404252

Genetic factors such as allelic variants of the PSEN1, PSEN2, APP, and APOE genes play an important role in Alzheimer's disease development. Still, they cannot explain all cases of the disease and cannot form the basis for effective treatment methods for the pathology. Alzheimer's disease is the most common neurodegenerative disease, so identifying new mechanisms of pathogenesis may reveal new ways of treating it. Since Alzheimer's disease is associated with aging, the hypothesis is proposed that an important trigg [...]

by Iyus Yosep  , Ai Mardhiyah  , Kurniawan Kurniawan  and Indra Maulana

Received: 21 July 2024;  Published: 25 October 2024;  doi: 10.21926/obm.neurobiol.2404251

Bullying is a serious problem among adolescents with broad negative impacts on psychological and social well-being. Factors that influence bullying are individual and environmental. Emotional intelligence has been identified as an essential factor influencing bullying behavior, but its relationship is not fully understood. This research aims to conduct a scoping review of the relationship between emotional intelligence and adolescent bullying behavior. A scoping review approach was used in this research. Search for [...]

by Nadia A. Abdelmegeed Abdelwahed  and Muhammad Sufyan Ramish

Received: 25 July 2024;  Published: 18 October 2024;  doi: 10.21926/obm.neurobiol.2404250

Entrepreneurs face massive challenges when attempting to create sustainable businesses in the current era. This juggling act leads to eco-anxiety and climate change anxiety, which mainly affect entrepreneurs by creating concerns and ruining creativity and progress. These issues contribute to individuals' mental health problems (MHP) and severely affect psychological well-being (PWB). With this in mind, the present study investigates the impact of eco-anxiety (EA) and climate change anxiety (CCA) on MHP and PWB amon [...]

by Rohman Hikmat  , Iyus Yosep  , Efri Widianti  , Suryani Suryani  , Aat Sriati  and Icih Susanti

Received: 20 July 2024;  Published: 12 October 2024;  doi: 10.21926/obm.neurobiol.2404249

To describe the application of the Stuart Stress Adaptation and Nola Pender Models in mental nursing care for a patient with schizophrenia and risk of violent behavior. This research method used case studies. The sample is one patient with schizophrenia. Data collection is done through direct observation, interviews, and patient medical records. The results showed that the client showed a major nursing problem in the form of risk of violent behavior. Predisposing factors included passive childhood experiences and s [...]

by Danilo Donati  , Giacomo Farì  , Federica Giorgi  , Vincenza Amoruso  , Valentina Boetto  , Riccardo Marvulli  , Laura Dell'Anna  , Andrea Bernetti  and Roberto Tedeschi

Received: 31 May 2024;  Published: 10 October 2024;  doi: 10.21926/obm.neurobiol.2404248

This review examines the effectiveness of integrating botulinum toxin type A (BONT-A) with various rehabilitative strategies in treating spastic diplegia in children. The studies analyzed consistently demonstrate significant reductions in spasticity and improvements in gait when BONT-A is combined with interventions such as intensive physical therapy, serial casting, electrical stimulation, physiotherapy, occupational therapy, and robotic-assisted gait training. The findings underscore the importance of personalize [...]

by Mohammad Shabani  , Elham Hassanpour  , Fatemeh Aghighi  , Mojgan Mohammadifar  , Fereshteh Bahmani  and Sayyed Alireza Talaei

Received: 11 May 2024;  Published: 30 September 2024;  doi: 10.21926/obm.neurobiol.2403247

Diabetic neuropathy (DN) is a type of nerve damage caused by long-term hyperglycemia in diabetes mellitus (DM). The gut microbiota alters in DM. Therefore, improvement of the gut flora may affect neuropathic pain and oxidative biomarkers' responsiveness to the probiotic treatment. The present study aimed to assess the effects of probiotic supplementation on neuropathic pain and oxidative stress biomarkers in diabetic rats’ serum. Forty-eight rats (200-250 g) were randomly divided into four groups (n = 12 per group) [...]

by Mahintaj Dara  , Zahra Karimi  , Mehdi Dianatpour  and Hadi Aligholi

Received: 02 June 2024;  Published: 30 September 2024;  doi: 10.21926/obm.neurobiol.2403246

Zebrafish (Danio rerio) is a vertebrate with unique characteristics, making it an excellent biomedical research animal model. One research area involves investigating changes in gene expression during neurodegenerative processes, aging-related changes, and behavioral studies in zebrafish. To achieve this, high-quality and quantity RNA must be extracted from zebrafish. This study aims to develop an optimized RNA extraction method from zebrafish larvae brains. After rearing and maintaining the zebrafish in suitable c [...]

by Nadia A. Abdelmegeed Abdelwahed  and Muhammad Sufyan Ramish

Received: 21 May 2024;  Published: 18 September 2024;  doi: 10.21926/obm.neurobiol.2403245

University entrepreneurs' psychological wellbeing (PWB) is a gigantic problem that substantially affects their academic performance, health, innovative capabilities, and more comprehensive societal contributions. In this study, we examine mental hindrances, such as stress, anxiety and depression and entrepreneurship-related constructs, such as entrepreneurial purpose (ENSE), entrepreneurial carefulness (ENSS) and entrepreneurial desire (ENRE) that predict PWB among Egyptian university entrepreneurs. In this quantit [...]

by Manuel De Jesus Encarnacion Ramirez  , Nikolay Konovalov  , Stanislav Kaprovoy  , Gennady Chmutin  , Geovany Venegas Cerna  , Renat Nurmukhametov  , Andreina Rosario Rosario  , Kalin Ivan Yakovlevich  , Jesus Lafuente  , Eric Suero Molina  and Nicola Montemurro

Received: 20 April 2024;  Published: 09 September 2024;  doi: 10.21926/obm.neurobiol.2403244

Gliomas are the most common brain tumor in adults, with a poor prognosis despite intensive treatments. Complete surgical resection is difficult due to its infiltrative growth, but aggressive surgery improves outcomes. Fluorescence-guided surgery (FGS) is used to distinguish tumor tissue during surgery. 5-Aminolevulinic Acid (5-ALA) is a crucial fluorescent agent in FGS, transforming into a molecule that accumulates in tumor cells. We presented a 34-year-old female with a high-grade glioma in the left parietal lobe [...]

by Igor Val Danilov  and Sandra Mihailova

Received: 12 March 2024;  Published: 28 August 2024;  doi: 10.21926/obm.neurobiol.2403243

This pilot study (N = 28) aims to develop universal computer-aided empathy training. The experiment tests a research design of manipulating behavior in subjects toward non-affective cues in a bioengineering system. The study implements the Mother-Fetus Neurocognitive Model to involve subjects in subliminal cognitive collaboration with confederates, which enables subjects to associate the meaning of empathy with the picture only seen by confederates. The outcome shows the feasibility of the chosen research design wi [...]