Macroscopic Aspergillus Infection at the Anastomosis of a Lung Transplant RecipientAbstract A 65-year-old female with a history of right lung transplantation (LTx) for chronic obstructive pulmonary disease (COPD) 9-years prior complicated by grade 3 bronchiolitis obliterans syndrome (BOS) was admitted to the hospital for chest pain and dyspnea on exertion (DOE). Her bronchoscop [...] 970 6520 |
|
Open Access Short Communication Lack of Effect of Human Chorionic Gonadotropin in Mixed Lymphocyte Reaction in XenotransplantationAbstract It has been speculated that the immunomodulation associated with pregnancy, e.g., decreasing pro-inflammatory cytokines, increasing anti-inflammatory cytokines, upregulation of T regulatory cells (Tregs), is in part due to the effect of human chorionic gonadotropin (hCG). In this study, [...] 1143 6603 |
Cytomegalovirus in Lung TransplantAbstract Lung transplantation is a therapeutic option for patients with advanced lung diseases. Lung transplant outcomes have improved over time with improvements in the management of these complex patients. Cytomegalovirus is a common opportunistic organism affecting all solid organ transplant r [...] 1178 10395 |
Effects of Oxygen on Renal Function and Oxidative Stress During Hypothermic Machine Perfusion in an Experimental Porcine Model of Kidney Donation after Cardiac Deathby
Victoria Gómez-Dos-Santos
,
Vital Hevia-Palacios
,
María Laura García-Bermejo
,
Alberto Alcázar-González
,
Miren Edurne Ramos-Muñoz
,
Laura Salinas-Muñoz
,
Elisa Conde-Moreno
,
Alejandro Escobar-Peso
,
Ana Belén Serrano-Romero
,
Ana Saiz-González
,
Miriam Menacho-Román
and
Francisco Javier Burgos-Revilla
Abstract The efficacy and safety of using high concentrations of oxygen during hypothermic machine perfusion (HMP) have not been fully elucidated to date. This study investigated the impact of administering high concentrations of oxygen on renal function during HMP in a porcine donation after cir [...] 937 6925 |
Beyond CPRA: Identifying Sensitized Kidney Candidates with Markedly Low Access to Deceased Donor Transplantation by Granular CPRA and Blood Typeby
Angela Q Maldonado
,
Kristoffer Sjöholm,
,
Joshua Lee
,
Håkan Olsson
,
Christian Kjellman
and
Darren E Stewart
Abstract Prioritization in the US Kidney Allocation System (KAS) has led to an improvement in the rates of transplantation in highly sensitized (HS) patients. However, there is a subset of HS patients who are at a disadvantage, despite prioritization under KAS. The purpose of this study was to de [...] 1296 8811 |
Generation of Unexpected Allele-Specific Anti-HLA Antibodies after the Transplantation of a Fully-Matched Kidney Allograft and the Diagnostic Approaches Required for Excluding Harmful Effects after Subsequent Renal RegraftsAbstract The specification of anti-human leukocyte antigen (HLA) antibodies is an important task for patients awaiting kidney allografts. Especially the patients immunized in previous transplantations, transfusions, or pregnancies must be carefully observed, since grafting patients with HLA antig [...] 1261 8587 |
The Great Masquerade: Donor-derived Infections with Uncommon Central Nervous System PathogensAbstract Donor-derived infections (DDI) are an infrequent event in solid organ transplant (SOT) due to advances in screening recommendations, prophylaxis, and surveillance of common infections. However, unexpected pathogen transmission can still occur when a donor is not known to be infected prio [...] 874 91028 |
The Future of Clinical Islet Transplantation in the United StatesAbstract Clinical islet transplantation was first realized over four decades ago at the University of Minnesota. Autologous islet transplantation is now widely recognized as a treatment to prevent diabetes in patients after pancreas excision and is offered at major transplant centers throughout the United St [...] 1122 11234 |
Acute Graft-Versus-Host Disease, Prophylaxis and Therapyby
Nidhi Sharma
and
Yvonne Efebera
Abstract Graft-versus host disease is one of the major causes of death in patients undergoing allogeneic hematopoietic stem cell transplantation. Major contributing factors to severity of graft-versus host disease include HLA mismatch, conditioning regimen intensity, age of donor and recipient, source of ste [...] 1076 8988 |
|
Open Access Short Communication Reconstruction of Aberrant Left Hepatic Artery in Orthotopic Liver Transplantation – Single Center Experienceby
Plamen Mihaylov
,
Burcin Ekser
,
Daiki Soma
,
Andrew Lutz
,
Jonathan Fridell
and
Chandrashekhar A. Kubal
Abstract One of the most feared complications in liver transplantation is hepatic arterial thrombosis (HAT). The incidence of HAT in liver transplantation varies from 1.2% and 8%. One of the risk factors for this complication is anatomical complexity of hepatic arterial system. The focus of this short commun [...] 1190 8705 |