Table of Content

Open Access Review

Medawar's Paradox and Immune Mechanisms of Fetomaternal Tolerance

Received: 09 May 2019;  Published: 10 March 2020;  doi: 10.21926/obm.transplant.2001104


Brazilian-born British biologist Dr. Peter Medawar played an integral role in developing the concepts of immunologic rejection and tolerance, which led to him receiving the Nobel Prize “for the discovery of acquired immunologic tolerance” and eventually made organ transplantation a reality. However, [...]

373 1737

Open Access Review

Histoplasmosis in Liver Transplant Recipients: Case Reports and a Review of the Literature

Received: 21 October 2019;  Published: 28 February 2020;  doi: 10.21926/obm.transplant.2001103


We report two cases of histoplasmosis in orthotopic liver transplant (OLT) recipients to illustrate the variable presentations, complications encountered during treatment, the spectrum of diagnostic modalities, and case outcomes. Case 1 describes the insidious presentation of presumed gastrointestin [...]

248 1723

Open Access Research Article

Febrile Neutropenia in Children: Etiologies, Outcomes, and Risk Factors with Prolonged Fever

Received: 27 November 2019;  Published: 21 February 2020;  doi: 10.21926/obm.transplant.2001102


Most studies of children with prolonged fever and neutropenia (PFN) have focused on invasive fungal disease (IFD) as the etiology of fever and not on other causes. Data are lacking regarding risk factors and adverse outcomes in pediatric cancer patients with PFN compared with those whose fevers reso [...]

262 1582

Open Access Review

Hematopoietic Stem Cell Transplantation in Refractory Celiac Disease: An Overview with Focus on Infectious Complications

Received: 16 December 2019;  Published: 18 February 2020;  doi: 10.21926/obm.transplant.2001101


Refractory celiac disease (RCD) is a rare condition in which a known celiac patient, usually an adult, suffers from persistence or recurrence of gluten-related symptomatology, laboratory abnormalities, and inflammatory enteropathy despite following an optimal dietary therapy with gluten-free diet (G [...]

212 1364

Open Access Editorial

Transplantation of a Kidney with an Extra-Renal Organ

Received: 10 February 2020;  Published: 13 February 2020;  doi: 10.21926/obm.transplant.2001100

193 1310

Open Access Original Research

Eplet-Based HLA Class II Matching for Transplantation: Design of a Repertoire of Interlocus Eplets Shared between HLA-DR, -DQ and -DP Alleles

Received: 13 December 2019;  Published: 10 February 2020;  doi: 10.21926/obm.transplant.2001099


Many studies have demonstrated that HLA-DR, HLA-DQ and HLA-DP matching at the eplet level reduces allograft rejection and improves transplant outcome. Such studies have examined the eplet effect for the individual class II loci, but until now little attention has been given to so-called interlocus c [...]

369 1630

Open Access Review

Utility of Fungal Cell Markers in Pediatric Bone Marrow Transplant Recipients for Screening and Diagnosis of Invasive Fungal Infections

Received: 12 November 2019;  Published: 04 February 2020;  doi: 10.21926/obm.transplant.2001098


Invasive fungal disease (IFD) is a significant contributor to morbidity and mortality in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT). Early detection and timely initiation of antifungal therapy is important for improved outcome, but diagnosis remains difficult, espec [...]

209 1514

Open Access Editorial

Immunosuppression in Kidney Transplantation

Received: 19 January 2020;  Published: 03 February 2020;  doi: 10.21926/obm.transplant.2001097


Immunosuppressive therapy in renal transplantation is divided into two phases as induction and maintenance therapy. Induction therapy is an intense immunosuppressive therapy administered at the time of kidney transplantation to reduce the risk of acute allograft rejection. In general, induction immu [...]

198 1666

Open Access Case Report

Dual Kidney Transplantation after Hypothermic Oxygenated Perfusion from Marginal Donor after Circulatory Death with Acute Kidney Injury: A Case Report

Received: 22 November 2019;  Published: 03 February 2020;  doi: 10.21926/obm.transplant.2001096


Donation after circulatory death (DCD) is an increasingly used resource to alleviate chronic renal graft shortages. Organs from donors with progressively increased creatinine levels due to acute kidney injury are used, but the effects of this condition on kidney transplantation are still unclear. Ex [...]

233 1363

Open Access Research Article

Long-Term Exposure to Fine Particulate Matter (PM2.5) and Cardiovascular Disease Mortality among Renal Transplant Recipients

Received: 11 August 2019;  Published: 17 December 2019;  doi: 10.21926/obm.transplant.1904095


Background: Substantial evidence has been used to establish links between air pollution and increased risks of overall health morbidity and mortality, especially for respiratory and cardiovascular diseases. However, very few investigations have explored these relationships among highly sensitive pop [...]

227 1606