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Open Access

ISSN 2577-5790

© 2019 by the authors; CC BY 4.0 licence

OBM Genetics , Volume 3 , Issue 4 (2019)

Pages: 143

Published: April 2020

(This book is a printed edition that was published in OBM Genetics)

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Cover Story: Cancer is probably caused by the very common chromosome mis-segregation at cell division. The organism has at least five mechanisms to prevent that mis-segregation damage develops into cancer. The mechanisms are tetraploidization, cell division arrest, apoptosis, elimination by the immune system, and prevention of division of macrophage/precancer cell fusions. View this paper.

Volume 3,Issue 4

Open Access Review

The Role of Genetic Counseling in Gynecological Oncology

Received: 15 July 2019;  Published: 12 December 2019;  doi: 10.21926/obm.genet.1904101

Abstract

Background: Clinical or medical genetics deals with the study and diagnosis of genetic diseases. It is oriented to the formulation of the clinical diagnosis of genetic diseases and genetic counseling, in order to evaluate the possible reproductive risk for the patient and his family. The geneticist is also called to play a diagnostic and preventive role for some of the most frequent diseases, such as cardiovascular disease and cancer. Methods: State-of-the-art by literature review. Results: Gene [...]

Open Access Hypothesis

Combination of the Hansemann-Boveri, Warburg, and Knudson Theories of Cancer, Based on Failure of Missegregation Damage Mitigation

Received: 17 July 2019;  Published: 03 December 2019;  doi: 10.21926/obm.genet.1904100

Abstract

The Hansemann-Boveri aneuploidy theory, the Warburg aerobic glycolysis theory, and the Knudson two-hit mutation theory can be seen as different aspects of a theory where the very common chromosome missegregation damage is mitigated by several quite different mechanisms. Cancer only occurs when all of these mechanisms have been inactivated in a single cell line, typically by mutation, for example by carcinogens. There are at least 5 different repair mechanisms which implies a multiple hit factor [...]

Open Access Review

Nutrition, Cancer Genetics and Epigenetics

Received: 01 October 2019;  Published: 28 November 2019;  doi: 10.21926/obm.genet.1904099

Abstract

A strong association has been established between nutrition and disease risk confirmed by epidemiological data and meta-analysis. In the context of cancer, unhealthy diets have been demonstrated to increase the risk of disease. On the other hand, major dietary interventions and lifestyle changes have provided therapeutic efficacy in cancer patients. Genetic mechanisms have been associated with cancer development triggered by environmental and nutritional factors. Genetics plays an important role [...]

Open Access Original Research

Diversity in the Bacterial Genus Dickeya Grouping Plant Pathogens and Waterways Isolates

Received: 25 July 2019;  Published: 26 November 2019;  doi: 10.21926/obm.genet.1904098

Abstract

Background: The Dickeya genus comprises aggressive soft rot plant pathogens with wide geographic distribution and host ranges. Ten Dickeya species have been characterised. Seven of them (D. chrysanthemi, D. dadantii, D. dianthicola, D. fangzhongdai, D. solani, D. paradisiaca, D. zeae) group causative agents of maceration-associated diseases that impact a wide variety of crops and ornamentals. As well as isolates from water sources. The three remaining species (D. aquatica, D. lacustris, D. undi [...]

Open Access Review

Optimizing Phage Translation Initiation

by
Received: 09 June 2019;  Published: 17 October 2019;  doi: 10.21926/obm.genet.1904097

Abstract

Phage as an anti-bacterial agent must be efficient in killing bacteria, and consequently needs to replicate efficiently. Protein production is a limiting step in replication in almost all forms of life, including phages. Efficient protein production depends on the efficiency of translation initiation, elongation and termination, with translation initiation often being rate limiting. Initiation signals such as Shine-Dalgarno (SD) sequences and start codon are decoded by anti-SD sequences and init [...]

Open Access Review

Insulin-Like Growth Factor 2 in Physiology, Cancer, and Cancer Treatment

Received: 14 May 2019;  Published: 14 October 2019;  doi: 10.21926/obm.genet.1904096

Abstract

IGF2 is a strongly mitogenic peptide and imprinted gene primarily involved in foetal development. In the foetus, IGF2 is highly expressed and is involved with foetal growth and tissue differentiation. However, postnatally IGF2 expression decreases although its expression level is still higher in blood than of IGF1. In adults, the physiological function of IGF2 is poorly understood, but may have a metabolic function. Although expression of IGF2 normally decreases in adults, IGF2 is overexpressed [...]
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