Cytogenetic and ISSR-Markers Polymorphism in the Population of Local Ukrainian Lebedyn Cows
Abstract
Volume 8,Issue 4
Cytogenetic and ISSR-Markers Polymorphism in the Population of Local Ukrainian Lebedyn CowsAbstract Preservation of the fund of local breeds of agricultural animals, which are breeding material for the creation of new ones and the improvement of existing ones, meets the requirements of the FAO - the protection of biological diversity. The study of the genetic structure of cows of the local Lebedyn breed, which was bred in Ukraine, with the use of cytogenetic and molecular genetic methods, is aimed at establishing information about the structure of the gene pool of these animals and the uniquen [...] |
Synergistic Effect of Resveratrol and Paclitaxel in the Treatment of Malignant Pleural MesotheliomaAbstract Malignant pleural mesothelioma (MPM) is a lethal and aggressive cancer due to exposure to asbestos since this carcinogen is still being used in industrial buildings and housing in several countries. Untreated MPM has a median survival time of 12 months, and most people die within 24 months after diagnosis. If caught early, surgery may be performed. Treatment option for palliative care is limited using platinum with pemetrexed. Malignant transformation of a cell is attributed to a series of genet [...] |
Effect of Drought Stress on Agronomic Traits and Total Leaf Proteins in Different Bottle Gourd [Lagenaria siceraria (Molina) Standl.] Genotypesby
Phumzile Mkhize
and
Phetole Mangena
Abstract Breeding drought-tolerant genotypes using genetic and biochemical tools is an important mitigation strategy to improve stress response and yields in bottle gourd [Lagenaria siceraria (Molina) Standl.]. This current study evaluated the variations among bottle gourd genotypes for potential breeding purposes by establishing the relationship between agronomic traits and the protein profile required for the plants’ resilience against drought stress. The study assessed 12 bottle g [...] |
Novel FLNC Gene Variant Associated with Hypertrophic Cardiomyopathyby
José A. Cedeño-Escudero.
,
Luis A. Sotillo-Bent.
,
Carolina Vega- Cuellar.
,
Rolando González-Angulo
,
Evelyn Medina-Batista
,
José Sotillo-Lindo
and
Luis A. Méndez-Rosado.
Abstract Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy, affecting approximately 1 in 500 people. It is the most common genetic cardiomyopathy inherited as a Mendelian trait in approximately 50% of patients, mainly due to pathogenic variants in genes encoding sarcomeric proteins. Mutations in the sarcomeric protein filamin C (FLNC) gene, with a cytogenetic localization on 7q32.1, have been linked to hypertrophic cardiomyopathy, as they have been determi [...] |
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