Special Issue

Long Non-coding RNAs in Genetic Disease

Submission Deadline: May 31, 2020 (Closed) Submit Now

Guest Editor

Gratien Prefontaine, PhD

Associate Professor, Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada

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Research Interests: Molecular biology; biochemistry; epigenetics; DNA methylation; CRISPR-CAS9; ChIP seq

About This Topic

This special issue will broadly cover mammalian genetic diseases concerning long non-coding RNAs (lncRNAs). Upon sequencing whole-cell human RNA, non-coding RNAs were suspected to be transcriptional noise. Now it is well established that they play many roles to influence transcription of protein-coding mRNAs as well as other functions. The human genome encodes more 58,000 lncRNAs eclipsing the number of genes that encode proteins. This issue will highlight recent research discoveries where lncRNAs have significant consequences for genetic disease.

There are two classes of non-coding RNAs, small RNAs (<200 nucleotides) and lncRNAs (>200 nucleotides). The later can act as chromatin organizers, guides for epigenetic modification and mRNA degradation, inhibitors of translation, modulators of nuclear architecture, RNA decoys and miRNA quenchers in addition to others. This issue will focus on molecular mechanisms and pathways of lncRNAs relevant to genetic diseases.

Understanding lncRNA function is of utmost importance and will inform on the etiology of many diseases. It will provide insight into treatment and offer novel approaches to the treatment of disease susceptibility, diagnoses, prognosis, drug selection and efficacy of therapy consistent with the root of genetic disorders and diseases.

Planned Paper

Title: lncRNAs in diseases of the hematopoietic and immune systems
Authors: Stefan A. Muljo, Young Uk Kim

Title: Computational Approaches to Functionally Characterize long noncoding RNA
Authors: Yashpal Ramakrishnaiah, Sonika Tyagi
Affiliation: Monash University Australia

Manuscript Submission Information

Manuscripts should be submitted through the LIDSEN Submission System. Detailed information on manuscript preparation and submission is available in the Instructions for Authors. All submitted articles will be thoroughly refereed through a single-blind peer-review process and will be processed following the Editorial Process and Quality Control policy. Upon acceptance, the article will be immediately published in a regular issue of the journal and will be listed together on the special issue website, with a label that the article belongs to the Special Issue. LIDSEN distributes articles under the Creative Commons Attribution (CC BY 4.0) License in an open-access model. The authors own the copyright to the article, and the article can be free to access, distribute, and reuse provided that the original work is correctly cited.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). Research articles and review articles are highly invited. Authors are encouraged to send the tentative title and abstract of the planned paper to the Editorial Office (genetics@lidsen.com) for record. If you have any questions, please do not hesitate to contact the Editorial Office.

Welcome your submission!