OBM Genetics is an international Open Access journal published quarterly online by LIDSEN Publishing Inc. It accepts papers addressing basic and medical aspects of genetics and epigenetics and also ethical, legal and social issues. Coverage includes clinical, developmental, diagnostic, evolutionary, genomic, mitochondrial, molecular, oncological, population and reproductive aspects. It publishes research articles, reviews, communications and technical notes, etc. There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.
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Tumor Micro-environment and Metastasis in Solid Tumors
Submission Deadline: January 31, 2022 (Open) Submit Now
Vidhula Ahire, PhD
Director, Discovery Oncology; Anticancer Bioscience; & J Micheal Bishop Institute of Cancer Research; Chengdu, China
Research Interests: tumor microenvironment; synthetic lethality; hyperthermia; radiation oncology
About this Topic
Tumors develop in multifaceted and dynamic microenvironments that influence their advancement, invasion, and metastasis. During progression, cancer cells persistently interact with the adjoining microenvironment through biophysical as well as biochemical cues that are both, dynamic and bidirectional. Evaluating such interactions will give a better insight on the fate of cancer cells and tumor heterogeneity that occurs from a diversity of signaling cross talks mechanisms existing in the complex association of interacting cancer cells. Microenvironmental parameters such as, hypoxia, locally secreted pro-inflammatory cytokines, extracellular matrix components, and mechanical properties etc. endorse the EMT to expedite the local invasion and metastatic dissemination. Also, normal cells surrounding the tumor tissues recurrently contribute in developing the chemotherapeutic drug resistance. Tumors interacts closely with the surrounding microenvironment, that is known to strongly impact tumor evolution and succession by regulating processes that accomplish tumor suppression, increased metastasis, and lay foundation for latent micrometastases. Since the TME influences the therapeutic response and imparts resistance to the tumor, understanding this relationship and interactions between different kinds of tumors and the TME will aid in targeting explicit mechanisms and the machinery involved in the bidirectional communication with the intent to implement better therapeutic regimes for cancer management. A combination strategy will be more effective rather than a single modality approach. Thus, with a view to recognize druggable targets which would aid in exploiting effective anti-cancer rationale, it is obligatory to elucidate the molecular level relationship of cancer cells with its intratumoral normal cells.
In this Special issue of “Tumor Micro-environment and Metastasis in Solid Tumors” we invite you to submit your latest progress and therapeutic interventions in various aspects of the TME but is not limited to the regulation of the TME, extracellular matrix and the tumor-associated stroma, tumor interactions, TME molecular markers, metastatic niche, tumor cell plasticity in microenvironments, drug targets for tumor cells and TME, preclinical and clinical trials associated with TME.
microenvironment; invasion & metastasis; chemoresistance; inflammation; hypoxia; signaling pathway; biomarkers; stemness & cell plasticity; targeted therapy; reactive oxygen species; small molecules.
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