(ISSN 2577-5790)
OBM Genetics is an international Open Access journal published quarterly online by LIDSEN Publishing Inc. It accepts papers addressing basic and medical aspects of genetics and epigenetics and also ethical, legal and social issues. Coverage includes clinical, developmental, diagnostic, evolutionary, genomic, mitochondrial, molecular, oncological, population and reproductive aspects. It publishes a variety of article types (Original Research, Review, Communication, Opinion, Comment, Conference Report, Technical Note, Book Review, etc.). There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.
Publication Speed (median values for papers published in 2023): Submission to First Decision: 5.1 weeks; Submission to Acceptance: 17.0 weeks; Acceptance to Publication: 7 days (1-2 days of FREE language polishing included)
Special Issue
Tumor Micro-environment and Metastasis in Solid Tumo
Submission Deadline: January 31, 2022 (Open) Submit Now
Guest Editor
Vidhula Ahire, PhD
Director, Discovery Oncology; Anticancer Bioscience; & J Micheal Bishop Institute of Cancer Research; Chengdu, China
Research Interests: tumor microenvironment; synthetic lethality; hyperthermia; radiation oncology
About this Topic
Tumors develop in multifaceted and dynamic microenvironments that influence their advancement, invasion, and metastasis. During progression, cancer cells persistently interact with the adjoining microenvironment through biophysical as well as biochemical cues that are both, dynamic and bidirectional. Evaluating such interactions will give a better insight on the fate of cancer cells and tumor heterogeneity that occurs from a diversity of signaling cross talks mechanisms existing in the complex association of interacting cancer cells. Microenvironmental parameters such as, hypoxia, locally secreted pro-inflammatory cytokines, extracellular matrix components, and mechanical properties etc. endorse the EMT to expedite the local invasion and metastatic dissemination. Also, normal cells surrounding the tumor tissues recurrently contribute in developing the chemotherapeutic drug resistance. Tumors interacts closely with the surrounding microenvironment, that is known to strongly impact tumor evolution and succession by regulating processes that accomplish tumor suppression, increased metastasis, and lay foundation for latent micrometastases. Since the TME influences the therapeutic response and imparts resistance to the tumor, understanding this relationship and interactions between different kinds of tumors and the TME will aid in targeting explicit mechanisms and the machinery involved in the bidirectional communication with the intent to implement better therapeutic regimes for cancer management. A combination strategy will be more effective rather than a single modality approach. Thus, with a view to recognize druggable targets which would aid in exploiting effective anti-cancer rationale, it is obligatory to elucidate the molecular level relationship of cancer cells with its intratumoral normal cells.
In this Special issue of “Tumor Micro-environment and Metastasis in Solid Tumors” we invite you to submit your latest progress and therapeutic interventions in various aspects of the TME but is not limited to the regulation of the TME, extracellular matrix and the tumor-associated stroma, tumor interactions, TME molecular markers, metastatic niche, tumor cell plasticity in microenvironments, drug targets for tumor cells and TME, preclinical and clinical trials associated with TME.
Keywords
microenvironment; invasion & metastasis; chemoresistance; inflammation; hypoxia; signaling pathway; biomarkers; stemness & cell plasticity; targeted therapy; reactive oxygen species; small molecules.
Manuscript Submission Information
Manuscripts should be submitted through the LIDSEN Submission System. Detailed information on manuscript preparation and submission is available in the Instructions for Authors. All submitted articles will be thoroughly refereed through a single-blind peer-review process and will be processed following the Editorial Process and Quality Control policy. Upon acceptance, the article will be immediately published in a regular issue of the journal and will be listed together on the special issue website, with a label that the article belongs to the Special Issue. LIDSEN distributes articles under the Creative Commons Attribution (CC BY 4.0) License in an open-access model. The authors own the copyright to the article, and the article can be free to access, distribute, and reuse provided that the original work is correctly cited.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). Research articles and review articles are highly invited. Authors are encouraged to send the tentative title and abstract of the planned paper to the Editorial Office (genetics@lidsen.com) for record. If you have any questions, please do not hesitate to contact the Editorial Office.
Welcome your submission!
Publication
Anti-cancer Drug Susceptibility of Breast Cancer Cells Incubated on Electrospun Polymeric Fiber SubstratesAbstract In this study, we examined the effect of a combination of surface topographies (fiber alignments) and different stiffness of poly(L-lactic acid) (PLLA) substrates on the direct relationship between anti-cancer drug (CDDP) sensitivity for MDA-MB-231 cells and mesenchymal properties under both normal and hypoxic conditions. In addition, we studi [...] |
| 2023 |  |
|
| CiteScore | SJR | SNIP |
| 0.4 | 0.160 | 0.093 |
TOP
Vidhi is a Clinical yoga therapist; mentor for yoga therapy training in Krishnamacharya tradition. She holds a MSc in Public health from Kings College London.
Mirela Olympia Fagarasan Palmer
Luigi Fontana, MD, PhD.jpg)
Zhong-Ting (Justin) is a PhD student from Nanyang Technological University (Singapore). He holds BSc in Applied Chemistry and MSc in Environmental Engineering. He was a R&D researcher of NanoMaterials Technology Pte Ltd in Singapore (2006-2012). His current research interests are functional nanomaterials synthesis & design, and their application into environmental/chemical engineering. He has published near 60 SCI papers in Applied Catalysis B, Chemical Engineering Journal and so on with H-Index 23. He also serviced as reviewers over 40 Journals such as Appl. Catal. B, Water Research, Chem. Eng. J, ACS Applied Materials & Interface, etc. He was honored such as “The Bsic Research Achievment 1st Award of CIESC”, “The ZJUT Fund Breeding Distinguished Young Scholars” etc.
Rolf Teschke studied Medicine in Munich and Marburg, where he finished his MD thesis before starting a residency at the Department of Pathology, University of Marburg. Subsequently and with a fellowship of the Deutsche Forschungsgmeinschaft, he worked at the Bronx VA Hospital/Mount Sinai Hospital in New York during 1972–1975 together with Professor Charles S. Lieber and successfully isolated MEOS and expanded its characterization. Back in Germany, he was at the Heinrich-Heine University in Düsseldorf with a focus on alcoholic liver disease, biochemical drug studies, and clinical intoxications by halogenated aliphatic hydrocarbons, where he became a Professor of Medicine. In 1987, he was offered a chief position and appointed as Director of the Medical Department II, City Hospital Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt/Main. His clinical and research interests are on liver injury by drugs and herbs including causality assessment by RUCAM in close association with Dr. Gaby Danan in Paris. A perfect cooperation exists also with Professor Tran Dang Xuan of the University of Hiroshima, Japan. Finally, he is the author of more than 275 publications including books and book chapters, and he is editor in chief of scientific journals and member of editorial boards.