(ISSN 2638-1311)
OBM Geriatrics is an Open Access journal published quarterly online by LIDSEN Publishing Inc. The journal takes the premise that innovative approaches – including gene therapy, cell therapy, and epigenetic modulation – will result in clinical interventions that alter the fundamental pathology and the clinical course of age-related human diseases. We will give strong preference to papers that emphasize an alteration (or a potential alteration) in the fundamental disease course of Alzheimer’s disease, vascular aging diseases, osteoarthritis, osteoporosis, skin aging, immune senescence, and other age-related diseases.
Geriatric medicine is now entering a unique point in history, where the focus will no longer be on palliative, ameliorative, or social aspects of care for age-related disease, but will be capable of stopping, preventing, and reversing major disease constellations that have heretofore been entirely resistant to interventions based on “small molecular” pharmacological approaches. With the changing emphasis from genetic to epigenetic understandings of pathology (including telomere biology), with the use of gene delivery systems (including viral delivery systems), and with the use of cell-based therapies (including stem cell therapies), a fatalistic view of age-related disease is no longer a reasonable clinical default nor an appropriate clinical research paradigm.
Precedence will be given to papers describing fundamental interventions, including interventions that affect cell senescence, patterns of gene expression, telomere biology, stem cell biology, and other innovative, 21st century interventions, especially if the focus is on clinical applications, ongoing clinical trials, or animal trials preparatory to phase 1 human clinical trials.
Papers must be clear and concise, but detailed data is strongly encouraged. The journal publishes research articles, reviews, communications and technical notes. There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.
Archiving: full-text archived in CLOCKSS.
Rapid publication: manuscripts are undertaken in 12 days from acceptance to publication (median values for papers published in this journal in 2021, 1-2 days of FREE language polishing time is also included in this period).
Special Issue
Aging of the Gut Microbiome: Potential Influences on Immunity and Inflammation
Submission Deadline: April 01, 2022 (Open) Submit Now
Guest Editor
Dr. Ravichandra Vemuri, PhD
Wake Forest Baptist Medical Center, Winston-Salem, NC 27101, USA
Research Interests: Aging; Microbiome; Metabolism; The immune system
About this Topic:
Aging is a natural and multifactorial process for all living organisms, involving decline in physiological functions of the host. The aging process has emerged as age-related health indicator, that affects the gastrointestinal (GI) physiology, predisposing a myriad of GI and cardiometabolic disorders. Development of next-generation sequencing and metagenomics has provided an insight into the function of the aging microbiome. However, research on microbiome in general with aging has many unresolved questions regarding whether there are any generalizable changes seen in normal/healthy ageing. However, some such questions include: (1) How and why does the microbiome change with aging? (2) the role of microbiome in context of inflammation, also known as inflamm-aging is still not known, (3) How do microbe– microbe, host–microbe, and microbe–host–immune system interactions change with age—do they co-occur, repel or compete? Understanding the microbial community has implications for prebiotic, probiotic, synbiotic (pre- and probiotic), and fecal transplant design and use. The objective of this Special Issue is to provide a common platform for researchers and clinicians working on human and animal research to exchange updated information on the age-related microbiome and inflammation. This Special Issue will consider reviews and research manuscripts ranging from laboratory to animal and human studies.
Keywords
Age; Fecal microbiome; Mucosal microbiome; Immunosenescence; Inflamm-aging
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Vidhi is a Clinical yoga therapist; mentor for yoga therapy training in Krishnamacharya tradition. She holds a MSc in Public health from Kings College London.
Mirela Olympia Fagarasan Palmer
Luigi Fontana, MD, PhD