OBM Geriatrics is an Open Access journal published quarterly online by LIDSEN Publishing Inc. The journal takes the premise that innovative approaches – including gene therapy, cell therapy, and epigenetic modulation – will result in clinical interventions that alter the fundamental pathology and the clinical course of age-related human diseases. We will give strong preference to papers that emphasize an alteration (or a potential alteration) in the fundamental disease course of Alzheimer’s disease, vascular aging diseases, osteoarthritis, osteoporosis, skin aging, immune senescence, and other age-related diseases.
Geriatric medicine is now entering a unique point in history, where the focus will no longer be on palliative, ameliorative, or social aspects of care for age-related disease, but will be capable of stopping, preventing, and reversing major disease constellations that have heretofore been entirely resistant to interventions based on “small molecular” pharmacological approaches. With the changing emphasis from genetic to epigenetic understandings of pathology (including telomere biology), with the use of gene delivery systems (including viral delivery systems), and with the use of cell-based therapies (including stem cell therapies), a fatalistic view of age-related disease is no longer a reasonable clinical default nor an appropriate clinical research paradigm.
Precedence will be given to papers describing fundamental interventions, including interventions that affect cell senescence, patterns of gene expression, telomere biology, stem cell biology, and other innovative, 21st century interventions, especially if the focus is on clinical applications, ongoing clinical trials, or animal trials preparatory to phase 1 human clinical trials.
Papers must be clear and concise, but detailed data is strongly encouraged. The journal publishes research articles, reviews, communications and technical notes. There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.
Archiving: full-text archived in CLOCKSS.
Rapid publication: manuscripts are undertaken in 12 days from acceptance to publication (median values for papers published in this journal in 2021, 1-2 days of FREE language polishing time is also included in this period).
Diabetes in the Elderly
Submission Deadline: November 30, 2019 (Open) Submit Now
P. Hemachandra Reddy, Ph.D.
Professor of Internal Medicine, Neuroscience/Pharmacology, Neurology and Public Health Texas Tech University Health Sciences Center, 3601 4th Street / MS / 9424 / 4B 207, Lubbock, Texas 79430, USA
Research Interests: Aging; neurodegenerative diseases - Alzheimer’s, Huntington’s, Parkinson’s and multiple sclerosis; mitochondria; oxidative stress; diabetes/obesity; gene expression analysis and gender-based neuronal changes
by Zheer Al-Mashhadi , Rikke Viggers , Rasmus Fuglsang-Nielsen , Bente Langdahl , Peter Vestergaard , Søren Gregersen and Jakob Starup-Linde
Received: 02 April 2020; Published: 18 June 2020; doi: 10.21926/obm.geriatr.2002123
Type 2 diabetes mellitus (T2DM) and osteoporosis are two major public health concerns worldwide, contributing to morbidity and mortality in the elderly. Aging is one of the most significant risk factors for low bone mass, bone fragility, and fractures. Among the several comorbidities that affect the elderly with diabetes, increased fracture [...]
Received: 05 March 2020; Published: 01 April 2020; doi: 10.21926/obm.geriatr.2002113
The prevalence of diabetes in older people is increasing. Diabetes in old age is associated with increased risk of mental dysfunction. Cognitive dysfunction and mood disorders such as depression, anxiety and diabetes-related distress tend to coexist in older people with diabetes and appear to have bidirectional relationship acting as a risk [...]
Received: 14 October 2019; Published: 10 January 2020; doi: 10.21926/obm.geriatr.2001099
Second-generation antipsychotics, have known metabolic side effects; specifically, clozapine is implicated in worsening or causing hyperglycemia, hypercholesterolemia and weight gain. Recently, there has been an increased interest in the safe use of clozapine in patients with diabetes. In March 2018, a 65-year-old female with a diagnosis of [...]
The Association between Bone Turnover Markers and Fracture in People with Diabetes: A Systematic Review and Meta-Analysis
Received: 29 August 2019; Published: 04 December 2019; doi: 10.21926/obm.geriatr.1904090
Background: The increased fracture risk in persons with diabetes is underestimated by conventional fracture predictors. The aims of this study were to conduct a systematic review and a meta-analysis to compare the levels of bone turnover markers (BTM) in persons with diabetes with and without fractures. Methods: We conducted a systematic liter [...]
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