Comparison of Post-mortem 7.0-Tesla Magnetic Resonance Imaging of the Brains of Alzheimer Patients with and without Cerebral Amyloid Angiopathy
Abstract
(ISSN 2638-1311)
OBM Geriatrics is an international peer-reviewed Open Access journal published quarterly online by LIDSEN Publishing Inc. The journal takes the premise that innovative approaches – including gene therapy, cell therapy, and epigenetic modulation – will result in clinical interventions that alter the fundamental pathology and the clinical course of age-related human diseases. We will give strong preference to papers that emphasize an alteration (or a potential alteration) in the fundamental disease course of Alzheimer’s disease, vascular aging diseases, osteoarthritis, osteoporosis, skin aging, immune senescence, and other age-related diseases.
Geriatric medicine is now entering a unique point in history, where the focus will no longer be on palliative, ameliorative, or social aspects of care for age-related disease, but will be capable of stopping, preventing, and reversing major disease constellations that have heretofore been entirely resistant to interventions based on “small molecular” pharmacological approaches. With the changing emphasis from genetic to epigenetic understandings of pathology (including telomere biology), with the use of gene delivery systems (including viral delivery systems), and with the use of cell-based therapies (including stem cell therapies), a fatalistic view of age-related disease is no longer a reasonable clinical default nor an appropriate clinical research paradigm.
Precedence will be given to papers describing fundamental interventions, including interventions that affect cell senescence, patterns of gene expression, telomere biology, stem cell biology, and other innovative, 21st century interventions, especially if the focus is on clinical applications, ongoing clinical trials, or animal trials preparatory to phase 1 human clinical trials.
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Special Issue
Cerebrovascular Biomarkers in Alzheimer's Disease
Submission Deadline: April 15, 2021 (Open) Submit Now
Guest Editor
Jacques De Reuck, MD, PhD
Professor, Université Lille 2, INSERM U1171 Degenerative & Vascular Cognitive Disorders, Lille, France
Research Interests: Dementia; cognitive impairment; Alzheimer's disease; ischemic stroke; neurodegenerative diseases; cerebrovascular diseases; vascular dementia
About This Topic
The significance of small cerebrovascular lesions is frequently overlooked in patients with Alzheimer’s disease. These lesions are most commonly due to cerebral amyloid angiopathy, which is mainly associated in the end-stages of the disease. Also Alzheimer’s disease can be mixed with arteriosclerotic small-vessel disease. The most common small cerebrovascular lesions are cortical micro-bleeds, cortical micro-infarcts, white matter changes, lacunar infarcts and superficial cortical siderosis. These lesions can be best detected with 7.0-tesla magnetic resonance imaging in vivo and on post-mortem examination, when the diagnosis of Alzheimer’s disease has to be confirmed for the family.
The final message is that in patients with suspected Alzheimer’s disease the vascular risk factors, such as arterial hypertension, hypercholesterolemia and diabetes, have to be treated as early as possible and smoking has to be avoided.
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Publication
Comparison of Post-mortem 7.0-Tesla Magnetic Resonance Imaging of the Brains of Alzheimer Patients with and without Cerebral Amyloid Angiopathyby
Jacques De Reuck
,
Florent Auger
,
Nicolas Durieux
,
Claude-Alain Maurage
,
Vincent Deramecourt
,
Charlotte Cordonnier
,
Florence Pasquier
,
Didier Leys
and
Regis Bordet
Abstract Purpose: The influence of cerebral amyloid angiopathy (CAA) in Alzheimer’s disease (AD) remains unexplored. The present post-mortem study investigated possible differences in the degree of hippocampal atrophy (HA) between AD patients with and without CAA using 7.0-tesla magnetic resonance imaging (MRI). Also, the incidence of the hippocampal [...] |
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