OBM Geriatrics is an Open Access journal published quarterly online by LIDSEN Publishing Inc. The journal takes the premise that innovative approaches – including gene therapy, cell therapy, and epigenetic modulation – will result in clinical interventions that alter the fundamental pathology and the clinical course of age-related human diseases. We will give strong preference to papers that emphasize an alteration (or a potential alteration) in the fundamental disease course of Alzheimer’s disease, vascular aging diseases, osteoarthritis, osteoporosis, skin aging, immune senescence, and other age-related diseases.

Geriatric medicine is now entering a unique point in history, where the focus will no longer be on palliative, ameliorative, or social aspects of care for age-related disease, but will be capable of stopping, preventing, and reversing major disease constellations that have heretofore been entirely resistant to interventions based on “small molecular” pharmacological approaches. With the changing emphasis from genetic to epigenetic understandings of pathology (including telomere biology), with the use of gene delivery systems (including viral delivery systems), and with the use of cell-based therapies (including stem cell therapies), a fatalistic view of age-related disease is no longer a reasonable clinical default nor an appropriate clinical research paradigm.

Precedence will be given to papers describing fundamental interventions, including interventions that affect cell senescence, patterns of gene expression, telomere biology, stem cell biology, and other innovative, 21st century interventions, especially if the focus is on clinical applications, ongoing clinical trials, or animal trials preparatory to phase 1 human clinical trials.

Papers must be clear and concise, but detailed data is strongly encouraged. The journal publishes a variety of article types (Original Research, Review, Communication, Opinion, Comment, Conference Report, Technical Note, Book Review, etc.). There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.

Publication Speed (median values for papers published in 2023): Submission to First Decision: 5.7 weeks; Submission to Acceptance: 17.9 weeks; Acceptance to Publication: 7 days (1-2 days of FREE language polishing included)

Current Issue: 2024  Archive: 2023 2022 2021 2020 2019 2018 2017

Special Issue

Depression in Older Adults

Submission Deadline: April 30, 2022 (Open) Submit Now

Guest Editor

Associate Professor Ling Xu, PhD

School of Social Work, University of Texas at Arlington, Arlington, TX 76019, USA

Website | E-Mail

Research Interests: Family Gerontology; Intergenerational Relations; Dementia Caregiving; Cross Culture Research; Health Outcomes in Later Life; Physical and Psychological Well-Being of Older Population

About This Topic

Depression is a common problem among older adults, but clinical depression is not a normal part of aging. Late-life depression can have devastating consequences. Despite its prevalence, depression is under studied among older adults. This Special Issue entitled “Depression in the Elderly” aims at convening basic and clinical research to foster our understanding of the mechanism/pathways between determents and/or protective or risk factors and depression, the influences of depression on other health aspects, as well as interventions or services that help with prevention and decreasing of depression among older adults. Research/clinical notes, systematic review, research protocol, empirical research with cross-sectional and longitudinal data, as well as evaluation of intervention/program on late-life depression are all relevant and welcome by this special issue.


Late-life depression; Depressed older adults; Depressive symptoms; Major depressive disorder; Older adults

Manuscript Submission Information

Manuscripts should be submitted through the LIDSEN Submission System. Detailed information on manuscript preparation and submission is available in the Instructions for Authors. All submitted articles will be thoroughly refereed through a single-blind peer-review process and will be processed following the Editorial Process and Quality Control policy. Upon acceptance, the article will be immediately published in a regular issue of the journal and will be listed together on the special issue website, with a label that the article belongs to the Special Issue. LIDSEN distributes articles under the Creative Commons Attribution (CC BY 4.0) License in an open-access model. The authors own the copyright to the article, and the article can be free to access, distribute, and reuse provided that the original work is correctly cited.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). Research articles and review articles are highly invited. Authors are encouraged to send the tentative title and abstract of the planned paper to the Editorial Office (geriatrics@lidsen.com) for record. If you have any questions, please do not hesitate to contact the Editorial Office.

Welcome your submission!


Open Access Short Communication

Mental Health among the Elderly in Nepal: Special Emphasis on Depression

Received: 21 December 2023;  Published: 08 February 2024;  doi: 10.21926/obm.geriatr.2401268


This paper discusses the impact of Depression on the aging population. It also tries to explore the psychosocial risk factors and burden associated with geriatric depression in low-and-middle-income (LAMI) countries. Nepal, a South Asian developing country, is resource-poor and research-naïve. Research, in general, and mental health studies [...]
Open Access Short Communication

Evolution of Psychosomatic Diagnosis: From Masked Depression to Somatic Symptoms and Related Disorders

Received: 02 December 2022;  Published: 22 March 2023;  doi: 10.21926/obm.geriatr.2301228


This paper discusses the history and the concept of somatization from masked depression to somatic symptoms and related disorders in the Diagnostic and Statistical Manual of Mental Disorders (DSM). Evaluating the evolution of these terms and concepts along the time course is very interesting. DSM 5 revision was intended to increase the relevan [...]
Open Access Original Research

The Effects of Control Measures and Social Networks on Depression Among Older People During the SARS-CoV-2 Pandemic

Received: 26 June 2022;  Published: 26 December 2022;  doi: 10.21926/obm.geriatr.2204217


This study examined the correlates of change in the depressed state among people aged 65 and older during the SARS-CoV-2 pandemic, particularly the effects of crucial pandemic-related variables. Data were drawn from the longitudinal Survey of Health, Ageing and Retireme [...]
Open Access Original Research

The Role of General Medicine in the Evaluation of Frailty in the Elderly Population: Definition of a Standardized Instrument for the Correct Framing of Frailty and Comparison with Currently Existing Instruments for Stratification of Clinical Risk

Received: 08 September 2021;  Published: 04 March 2022;  doi: 10.21926/obm.geriatr.2201192


Frailty is a chronic condition that increases the vulnerability to stressogenic factors and prevents the patient from returning to the preceding condition of homeostasis. This increases the risk of negative outcomes and progressively brings the patient toward disability, leading to higher use of healthcare resources. Clinical risk stratificati [...]
Open Access Original Research

Adjustment for Covariates of Major Depressive Episodes among Men and Women Aged 65 Years Old and Older

Received: 17 August 2021;  Published: 22 December 2021;  doi: 10.21926/obm.geriatr.2104185


The current study aimed to examine if sex can significantly predict risk for lifetime major depressive episodes among adults aged 65 and older with and without adjustment for covariate variables of race, education, marital status, health, and poverty. Secondary data was obtained from the National Survey on Drug Use and Health public-use data [...]