IFN-Based and IFN-Free Direct-Acting Antiviral Drug Treatments for Acquired Hepatitis C Virus in Post-Transplant Recipients
by
Tomomi Kogiso
,
Mutsuki Kobayashi
,
Kuniko Yamamoto
,
Yuichi Ikarashi
,
Kazuhisa Kodama
,
Makiko Taniai
,
Nobuyuki Torii
,
Kazunari Tanabe
,
Hideki Ishida
,
Shohei Fuchinoue
,
Hiroto Egawa
,
Masakazu Yamamoto
,
Etsuko Hashimoto
and
Katsutoshi Tokushige














Abstract
Background: Hepatitis C virus (HCV) infection frequently occurs in recipients of liver or kidney transplants (LT/KT). Interferon (IFN)-based therapies are used to treat HCV, but their efficacy is low.
Methods: We report 24 patients who received HCV therapy after LT/KT.
Design, Setting, and Participants-Twelve LT and 12 KT recipients (median age, 59 years; 15 males; 21 serological type 1) were enrolled, of whom eight (six with LT) were treated with IFN-based therapy.
Twelve received direct-acti [...]