by Amale Laouar

Received: 22 July 2018;  Published: 09 September 2018;  doi: 10.21926/obm.hg.1803010

Gut microbes and pathophysiology of sepsis: Spillage of gut microbial products, rather than systemic dissemination of gut microbes, is the potential initiator of septic morbidity

by Shechter Yonat  , Dagan Amir  , Ben-Haim Menachem  , Bar-Ziv Yaakov  , Brazovsky Eliyau  , Shteingart Shimon  , Dancour Alian  , Paz Kalman  and Lurie Yoav

Received: 17 February 2018;  Published: 01 September 2018;  doi: 10.21926/obm.hg.1803009

Cholangiocarcinoma is an uncommon adenocarcinoma with poor prognosis. Signet ring cell cholangiocarcinoma is an extremely rare disease, with only 11 cases reported to date. However, its incidence is increasing. Similarly, there is an increasing incidence of other SRC tumors (colon, gastric etc.) as well. Most cases have described a localized mass of signet ring cells, mostly in the common bile duct. A 69-year-old Caucasian man admitted for jaundice and abdominal pain that began 3 days prior to [...]

by Katsuhisa Omagari  , Ayumi Fukuda  , Machiko Suga  , Ayumi Ogata  , Shinta Nishioka  , Kazuhito Suruga  , Mayuko Ichimura  and Koichi Tsuneyama

Received: 09 April 2018;  Published: 03 August 2018;  doi: 10.21926/obm.hg.1803008

Background: The pathogenesis of nonalcoholic steatohepatitis (NASH) is thought to be multifactorial, and oxidative stress may play an important role in the development of NASH. Peptides obtained by enzymatic decomposition of mackerel (EMP) including selenoneine were recently reported to possess antioxidative activity. Thus, EMP can be a candidate dietary strategy for the prevention of NASH. [...]