Table of Contents

Volume 2,Issue 2

Open Access Original Research

Haplo-Insufficiency or Knockout of the Serotonin Transporter Does not Affect Heroin Self-Administration but Decreases BDNF in the Frontal Cortex

Received: 01 February 2018;  Published: 07 June 2018;  doi: 10.21926/obm.neurobiol.1802010


(1) Background: Drug addiction places a heavy burden on those affected by it but only a small percentage of individuals (~20%), regardless of their drug of abuse, go on to develop the compulsive behaviours that define drug addiction. Clinical studies have shown that genetic variations that reduce serotonin transporter (SERT) activity increase the vulnerability to developing a variety of psychiatric disorders such as depression, anxiety and drug addiction. (2) Methods: To investigate the influenc [...]

Open Access Review

Temporal Lobe Epilepsy, Stroke, and Traumatic Brain Injury: Mechanisms of Hyperpolarized, Depolarized, and Flow-Through Ion Channels Utilized as Tri-Coordinate Biomarkers of Electrophysiologic Dysfunction

Received: 12 January 2018;  Published: 31 May 2018;  doi: 10.21926/obm.neurobiol.1802009


The brain is an integrated network of multiple variables that when compromised creates a disease state. The neuropathology of temporal lobe epilepsy, stroke, and traumatic brain injury demonstrate both similarity and complexity that reflects this integrated variability; temporal lobe epilepsy with its live human tissue resection research delivers reproducible genetic contributors such as channelopathies, and neurotransmitter deoxyribonucleic acid mutation, yet often fails to be consistent across [...]