Table of Contents

Volume 4,Issue 4

Open Access Review

The Therapeutic Potential of the Stem Cell Secretome for Spinal Cord Repair: A Systematic Review and Meta-Analysis

Received: 26 October 2020;  Published: 14 December 2020;  doi: 10.21926/obm.neurobiol.2004080

Abstract

There is currently no effective treatment for spinal cord injury leaving around 90% of patients with permanent disabilities. Stem cell therapies are showing promise in preclinical studies of central nervous system injury and there is increasing evidence suggesting the improvements in functional recovery are mediated by paracrine actions. In this systematic review and meta-analysis, we aimed to determine the overall efficacy of stem cell secretome therapies in promoting recovery in preclinical mo [...]

Open Access Case Report

Psychiatric Disorders in Mӧbius Sequence: Intermittent Presentation of Auto-Aggressive Outbursts

Received: 27 March 2020;  Published: 03 December 2020;  doi: 10.21926/obm.neurobiol.2004079

Abstract

Anecdotal evidence suggests the possible association of psychiatric disorders with Mӧbius sequence, although the evidence is not conclusive. Intermittent presentation of auto-aggressive outbursts, in particular, could be related to Mӧbius sequence, different from the common psychotic symptoms. The present report describes the clinical case of a young man with Mӧbius syndrome who exhibited a complex representation of severe mental retardation and concomitant psychiatric disorders. Extremely rare [...]

Open Access Original Research

Variations in Secondary Health Resource Utilization Post Clozapine Initiation

Received: 10 September 2020;  Published: 26 November 2020;  doi: 10.21926/obm.neurobiol.2004078

Abstract

This study looked at secondary care utilization metrics as an effectiveness indicator of Clozapine initiation in 77 patients over the following year compared to the year prior to initiation. It was found that there was a marginal drop in psychiatric bed utilization, alongside reduced crisis team use. Medical and psychiatric outpatient use increased, as did physical health interventions. Overall, compared with costs over the year preceding Clozapine initiation, an estimated saving per patient of [...]

Open Access Research Article

Transcriptome Signatures of Dysregulated Brain Dynamics Induce Entangled Network States.

Received: 15 June 2020;  Published: 30 December 2020;  doi: 10.21926/obm.neurobiol.2004077

Abstract

Marks of brain disorders may be visible through abnormal networks characterized by states with distinct signatures or connectivity patterns. Apart from neurodegenerations, drug abuse or eventually addiction may exert complex perturbative effects over human health, including damage to various organs and especially brain inflammation, volume shrinkage and functional deficits. These can also be regarded as signs of accelerated ageing, which involve multiple comorbidities associated with long-lastin [...]

Open Access Review

Palmitoylethanolamide for Neurological Disorders

Received: 04 October 2020;  Published: 30 December 2020;  doi: 10.21926/obm.neurobiol.2004076

Abstract

Neurological tissue along with the cartilage remains one of the tissues that escapes human efforts of regeneration after injury. The human body, after an injury, can repair its tissues only to a certain extent that can help in recovering the function of organs. However, this is not the case in some organs, such as the brain and spinal cord. For a long time, basic medical science has been investigating the regeneration process that helps the human body, which is mainly through the pharmacological [...]

Open Access Review

Peripheral Nerve Dysfunction after Spinal Cord Injury

Received: 02 October 2020;  Published: 29 December 2020;  doi: 10.21926/obm.neurobiol.2004075

Abstract

Spinal cord injury (SCI) leads to an immediate loss of sensory and motor function below the level of injury mostly affecting people in the prime of life. In addition to the primary injury there is accumulating neurophysiological and histological evidence of dysfunction in the peripheral nerves, not related to direct damage from the primary injury, which exacerbates muscle wasting, and contributes to further functional loss and poor recovery. Among the potential contributing factors are systemic [...]

Open Access Review

Celiac Disease and Associated Extraintestinal Manifestations, with Special Reference to Neurological Disorders

Received: 13 July 2020;  Published: 30 October 2020;  doi: 10.21926/obm.neurobiol.2004074

Abstract

Celiac disease (CD), also known as gluten-sensitive enteropathy and nontropical sprue, is one of the most important entities of the wide spectrum of gluten-related disorders (GRDs). It is well known that neurological manifestations can be present either at the onset of CD, or appear during the development of the pathology, and the neurologic findings can show a profound difference. Clinical features show significant variation, ranging from typical manifestations of gastrointestinal involvement t [...]

Open Access Case Report

A Case of Coincidental Association of Amyotrophic Lateral Sclerosis in a Patient with Celiac Disease Consuming a Gluten-Free Diet

Received: 30 June 2020;  Published: 12 October 2020;  doi: 10.21926/obm.neurobiol.2004073

Abstract

We report, for the first time, the case of amyotrophic lateral sclerosis (ALS) onset in a 54-year-old woman not following a strict gluten-free diet (GFD) for six years after the diagnosis of celiac disease (CD). The patient did not display any sign of gluten toxicity, malabsorption, or CD-related comorbidity. Previous cases reported in medical literature showed ALS-like forms secondary to gluten intolerance, with symptom remission after a strict GFD. Even after correcting dietary flaws, the clin [...]

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