Open Access
ISSN 2573-4407
© 2021 by the authors; CC BY 4.0 licence
OBM Neurobiology , Volume 5 , Issue 2 (2021)
Pages: 246
Published: October 2021
(This book is a printed edition that was published in OBM Neurobiology )
Cover story:Resistance to DNA damaging agents can occur by inefficient repair that allows damaged DNA to be misreplicated. This activity, termed translesion DNA synthesis, also drives mutagenesis to create more malignant cancers. Small molecules that inhibit translesion DNA synthesis activity are being developed to improve the efficacy of DNA damaging agents. View this paper.
Volume 5,Issue 2
Psilocybin as a Novel Pharmacotherapy for Treatment-Refractory Anorexia NervosaAbstract Anorexia Nervosa (AN) is a major health problem with one of the highest mortalities and treatment costs of any psychiatric condition. Cognitive behavioural therapy (CBT) is currently the most widely used treatment for AN in adults but provides remission rates ≤ 50%. Treatment drop-out is [...] |
Establishing and Evaluating a Multidisciplinary Community-Based Sleep Clinic for Children with Neurodevelopmental Difficulties in Inner LondonAbstract We describe our experience of setting up and evaluating a community-based multi-disciplinary sleep service for children with neurodevelopmental disorders and psychosocial vulnerabilities.Referrals are accepted for children (1-18 years of age) with persistent sleep problems, and neurodeve [...] |
The Trails Making Test. Does a Single Trial Reflect Performance Capability?Abstract Information processing speed (Reaction time, RT) to a single administration of the Trails A and Trails B components of the Trail Making Test (TMT) is used in the assessment of brain and behavioural functional integrity across the lifespan in both clinical and research contexts. Although [...] |
Management of Agitation, Delirium, and Catatonia in Intubated COVID-19 Patients: A Case Series & Rationale for Valproate Sodium Use During Extubationby
Ashley Schumaker
,
Richard Gomez
,
Sofia Rojasova
,
Cassidy Muir
,
Katie Bukiri
,
Clinton Korneffel
,
Aparna Sharma
,
Murali Rao
and
Edwin Meresh
Abstract The complete spectrum of neuropsychiatric effects of SARS-CoV-2 acute respiratory distress syndrome has yet to be fully appreciated, particularly in intubated patients. Manifestations including delirium and catatonia need to be considered in intubated COVID-19 patients. Medications known [...] |
Ocular Pressure-Volume Relationship and Ganglion Cell Death in Glaucomaby
Ji-Jie Pang
and
Samuel M. Wu
Abstract We studied how GC death in glaucoma related to the intraocular pressure (IOP), eyeball volume (VS) and elasticity (volumetric KS and tensile ES), and eyeball volume-pressure relation. Glaucomatous GC loss was studied in [...] |
A Systematic Review of the Biological Processes Involved in Deep-Brain Stimulation for Parkinson's disease: A Focus on the Potential Disease-Modifying Effectsby
Francesco Sciancalepore
,
Giulia Remoli
,
Leonardo Tariciotti
,
Giulia Sarti
,
Federica Trentin
,
Gabriele Riccardi
,
Eleonora Lacorte
,
Massimo Corbo
,
Marco Canevelli
,
Nicola Vanacore
and
Paola Piscopo
Abstract Deep-Brain Stimulation (DBS) is an important treatment option for the management of Parkinson’s disease (PD) and is a common symptomatic treatment. However, an increasing number of studies have examined the biological processes to assess if DBS can also modify the natural history of PD b [...] |
Examining the Role of Specialized DNA Polymerases in the Development of Temozolomide Resistance in Glioblastoma MultiformeAbstract Glioblastoma multiforme (GBM) is an extremely malignant type of primary brain tumor that exhibits a high mortality rate. Current standard therapy involves surgery followed by radiation and treatment with the DNA-alkylating agent, temozolomide (TMZ). While TMZ treatment can extend post-op [...] |
Computational Modelling of Deep Brain Stimulation for Parkinson's Disease: A Critical ReviewAbstract We review the use of numerical and computational models to explore deep brain stimulation for Parkinson’s disease (DBS PD). It is a review for the modeler and those interested in PD DBS modelling methods and their value. The main model categories of active fiber, mean field, driving force, and volum [...] |
A Participation-Focused Exercise Intervention for Children with Neurodevelopmental Disorders: Feasibility, Acceptability, and Impact on Sleep and WellbeingAbstract Sleep-related difficulties are common in children with neurodevelopmental disabilities. Poor sleep health is associated with detrimental impacts not only for the child/young person, but also their family members. Exercise is considered to be important for sleep health, improving duration [...] |
Visuospatial Executive Functions are Improved by Brief Brain Training in Young Rugby Players - Evidence of Far Transfer Test Effects: A Pilot StudyAbstract Brain training apps are becoming increasingly popular for at home use and as an adjunct to more traditional therapies. There is uncertainty about whether the effects of brain training transfer to real-world cognition, or performance on other cognitive assessment tests, or is specific onl [...] |
Psychological Considerations in the Etiology and Pathophysiology of Migrainesby
Niamh Flynn
Abstract Although studies to understand the pathogenesis of migraines are in progress, no theory has adequately explained the etiology and pathophysiology of migraines to date. This has affected the development of treatment strategies for migraineurs. Currently, the pharmacological treatment for [...] |
Lamotrigine-Associated Progressive Dysphasia and Cognitive Dysfunctionby
Joshua Brown
and
Jessica Broadway
Abstract Lamotrigine is generally accepted as a well-tolerated medication with few cognitive side effects. Here, we report a case of a 62-year old female with a severe, rapidly progressive dementia-like process which was completely reversed after reduction of lamotrigine. Associated findings included hyper [...] |
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