Table of Contents

Volume 9,Issue 2

Open Access Review

Mental Health Disorders Following Exposure to Endocrine Disruptor Chemicals

Received: 27 October 2024;  Published: 18 April 2025;  doi: 10.21926/obm.neurobiol.2502285

Abstract

There is growing scientific concern regarding how endocrine-disrupting chemicals (EDCs) impact central nervous system (CNS) disorders. Both anecdotal and preclinical studies suggest a link between EDC exposure and major depressive disorder (MDD), potentially leading to neurodegenerative outcomes. EDCs primarily exhibit their biological effects by interacting with hormone receptors. Nonetheless, there is scientific evidence pointing to dysfunction in the hypothalamic-pituitary-gonadal-adrenal axi [...]

Open Access Review

Neurotoxicity Following Exposure to Chlorpyrifos

Received: 14 January 2025;  Published: 15 April 2025;  doi: 10.21926/obm.neurobiol.2502284

Abstract

Neurotoxicity occurs when exposure to a biological, chemical, or physical agent, especially a neurotoxin, alters the normal activity of the nervous system in a way that results in permanent or reversible damage to neurons and nerve tissue and disrupts the functioning of the brain and nervous system. Chlorpyrifos is a broad-spectrum organophosphorus insecticide that has been used worldwide for more than 50 years and can damage the nervous system of insects by creating neurotoxicity. Epidemiologic [...]

Open Access Review

Unraveling the Involvement of Serotonergic 5-Hydroxytryptamine Receptor-6 Activation in Chronic Pain: A Narrative Review

Received: 28 September 2024;  Published: 09 April 2025;  doi: 10.21926/obm.neurobiol.2502283

Abstract

Chronic pain is a significant and global healthcare issue that hugely implies the quality of life and productivity of the affected individuals. It is challenging to treat and thus necessitates a deeper understanding of its underlying pathomechanisms to develop targeted interventions. Serotonin is one of the essential neurotransmitters involved in the propagation of pain signals through both ascending and descending pathways, acting via various receptor subtypes, including the 5-hydro [...]

Open Access Review

Pregnancy Risk Factors in Cerebrovascular Disease

Received: 16 May 2024;  Published: 01 April 2025;  doi: 10.21926/obm.neurobiol.2502282

Abstract

Cerebrovascular diseases such as strokes and cerebral hemorrhages are important causes of death in the world, which increase during pregnancy due to physiological conditions. This study investigated risk factors such as diabetes mellitus, hypertension and other factors by searching in databases. After searching, 35 articles were reviewed based on the inclusion criteria. The inclusion criteria included articles from 2014-2024 related to the words "pregnancy" AND "cerebrovascular di [...]