OBM Neurobiology is an international peer-reviewed Open Access journal published quarterly online by LIDSEN Publishing Inc. By design, the scope of OBM Neurobiology is broad, so as to reflect the multidisciplinary nature of the field of Neurobiology that interfaces biology with the fundamental and clinical neurosciences. As such, OBM Neurobiology embraces rigorous multidisciplinary investigations into the form and function of neurons and glia that make up the nervous system, either individually or in ensemble, in health or disease. OBM Neurobiology welcomes original contributions that employ a combination of molecular, cellular, systems and behavioral approaches to report novel neuroanatomical, neuropharmacological, neurophysiological and neurobehavioral findings related to the following aspects of the nervous system: Signal Transduction and Neurotransmission; Neural Circuits and Systems Neurobiology; Nervous System Development and Aging; Neurobiology of Nervous System Diseases (e.g., Developmental Brain Disorders; Neurodegenerative Disorders).

OBM Neurobiology  publishes a variety of article types (Original Research, Review, Communication, Opinion, Comment, Conference Report, Technical Note, Book Review, etc.). Although the OBM Neurobiology Editorial Board encourages authors to be succinct, there is no restriction on the length of the papers. Authors should present their results in as much detail as possible, as reviewers are encouraged to emphasize scientific rigor and reproducibility.

Publication Speed (median values for papers published in 2023): Submission to First Decision: 7.5 weeks; Submission to Acceptance: 15.9 weeks; Acceptance to Publication: 7 days (1-2 days of FREE language polishing included)

Current Issue: 2024  Archive: 2023 2022 2021 2020 2019 2018 2017

Special Issue

Evaluating the Effects of Natural Products on Cellular and Molecular Signaling Pathways for the Management of Neurodegenerative Diseases

Submission Deadline: September 15, 2024 (Open) Submit Now

Guest Editors

Dr. Shoib Ahmad Baba, PhD, Lecturer

Department of Education, Government of Jammu and Kashmir

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Research Interests: Natural products; Bioactivity; Antioxidant; Anti-inflammatory; Anti-apoptotic; Neurodegeneration; Signaling pathways; Phytochemicals

Tomohiro Chiba, MD, PhD

Assistant Professor, Department of Pathology, Kyorin University School of Medicine, Tokyo 181-8611, Japan

Website | E-Mail

Research Interests: neurodegenerative diseases; Alzheimer's disease; ALS; Parkinson's disease; neuropathology; neuropharmacology; intracellular signaling pathways; neuro-oncology; CNS malignancy

About This Topic

Neurodegenerative diseases, a heterogeneous group of diseases, are among the serious health issues that affect millions of people across the globe. The incidence of these diseases has significantly increased throughout the world, and it is believed that the risk of developing a neurodegenerative disease increases with age. Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, multiple sclerosis, and Huntington’s disease are the most common neurodegenerative diseases and are accompanied by cerebral cortical atrophy, neuronal loss, protein accumulation, and excessive accumulation of metal ions. In recent years, natural products of plant, animal, or fungal origin have been intensively explored and studied for their protective effects against neurodegenerative diseases. Natural products have the remarkable potential to improve cerebral circulatory disorders, promote cerebral hemostasis absorption, repair damaged nerve tissue, and improve damaged nerve function. Recently, studies have revealed that neuroinflammatory mechanisms and signaling pathways closely related to the occurrence, development, and progression of neurological diseases include microglial activation, the nuclear factor-κB (NF-κB) pathway, the mitogen activated protein kinases (MAPK) pathway, the reactive oxygen pathway, nucleotide binding oligomerization domain-like receptor protein3 (NLRP3) inflammasomes, the toll-like receptor4 (TLR4) pathway, the nuclear factor erythroid 2-related factor 2 (Nrf2)/hemeoxygenase-1 (HO-1) pathway, the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway, and intestinal flora. Many studies have shown that natural products can modulate these signaling pathways. Furthermore, they have been recognized to possess diverse biological activities such as antioxidant, anti-inflammatory, and anti-apoptotic. Thus, they exhibit the potential to be used for the management of neurodegenerative diseases.

The aim of this special issue is to gather papers that further our understanding of the role of natural products in regulating molecular and cellular signaling pathways involved in the development of neurodegenerative diseases.

We welcome original research papers and reviews that cover topics including:

  • Clinical or preclinical evaluation of natural products in the treatment of neurodegenerative diseases.
  • Effects of natural products on signaling pathways involved in neurodegeneration, such as the nuclear factor-κB (NF-κB) pathway, the mitogen-activated protein kinases (MAPK) pathway, and other related pathways.
  • Effect of natural products on oxidative stress in neurodegeneration.
  • Effect of natural products on modulating autophagy and proteasome activity to prevent abnormal protein aggregation in neurodegenerative diseases.
  • Natural products as lead compounds in drug discovery for the management of neurodegenerative diseases.
  • Network pharmacology in the identification of target neurodegenerative cellular and molecular signaling pathways of phytochemicals.

Manuscript Submission Information

Manuscripts should be submitted through the LIDSEN Submission System. Detailed information on manuscript preparation and submission is available in the Instructions for Authors. All submitted articles will be thoroughly refereed through a single-blind peer-review process and will be processed following the Editorial Process and Quality Control policy. Upon acceptance, the article will be immediately published in a regular issue of the journal and will be listed together on the special issue website, with a label that the article belongs to the Special Issue. LIDSEN distributes articles under the Creative Commons Attribution (CC BY 4.0) License in an open-access model. The authors own the copyright to the article, and the article can be free to access, distribute, and reuse provided that the original work is correctly cited.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). Research articles and review articles are highly invited. Authors are encouraged to send the tentative title and abstract of the planned paper to the Editorial Office (neurobiology@lidsen.com) for record. If you have any questions, please do not hesitate to contact the Editorial Office.

Welcome your submission!