OBM Neurobiology is an international peer-reviewed Open Access journal published quarterly online by LIDSEN Publishing Inc. By design, the scope of OBM Neurobiology is broad, so as to reflect the multidisciplinary nature of the field of Neurobiology that interfaces biology with the fundamental and clinical neurosciences. As such, OBM Neurobiology embraces rigorous multidisciplinary investigations into the form and function of neurons and glia that make up the nervous system, either individually or in ensemble, in health or disease. OBM Neurobiology welcomes original contributions that employ a combination of molecular, cellular, systems and behavioral approaches to report novel neuroanatomical, neuropharmacological, neurophysiological and neurobehavioral findings related to the following aspects of the nervous system: Signal Transduction and Neurotransmission; Neural Circuits and Systems Neurobiology; Nervous System Development and Aging; Neurobiology of Nervous System Diseases (e.g., Developmental Brain Disorders; Neurodegenerative Disorders).
OBM Neurobiology publishes research articles, technical reports and invited topical reviews. Although the OBM Neurobiology Editorial Board encourages authors to be succinct, there is no restriction on the length of the papers. Authors should present their results in as much detail as possible, as reviewers are encouraged to emphasize scientific rigor and reproducibility.
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Rapid publication: manuscripts are undertaken in 11.8 days from acceptance to publication (median values for papers published in this journal in the second half of 2021, 1-2 days of FREE language polishing time is also included in this period).
Ketogenic Diets: Neuroprotective/Anti-Inflammatory Effects, and Psychological Aspects
Submission Deadline: April 30, 2022 (Open) Submit Now
Edda Cava, MD
Unit of Dietetic and Clinical Nutrition, University Hospital "Maggiore della Carità", Novara, Italy
Research Interests: Malnutrition; clinical nutrition; nutritional and metabolic diseases; insulin resistance, obesity, bariatric surgery, healthy aging and longevity,
Sergio Riso, MD
1. Director of Unit of Dietetic and Clinical Nutrition, University Hospital "Maggiore della Carità", Novara, Italy
2. Vice-president SINPE, Italian Society for Artificial Nutrition and Metabolism
Research interest: Nutrition and dietetics; nutritional biochemistry; artificial nutrition, malnutrition in oncology; dysphagia, microbiota
About This Topic
Ketogenic diets (KD), dietary therapies particularly low in carbohydrates, have been used in neurology for over a century for refractory epilepsy. The application of KD is now expanding beyond the treatment of neurological disorders to multiple conditions, e.g. obesity, metabolic diseases and cancer.
During a KD, the brain's primary source of energy are ketone bodies as alternative for glucose. Ketones exert neuroprotective, antinflammatory effects, and other biological functions only partially known.
Recently, specific protocols very low in carbohydrates and lipids, very-low-calorie-KD (VLCKD) have been studied in obesity and diabetes, providing evidences of the systemic effects of ketones on the body in physiological and disease states.
Moreover, psychological aspects in KD are still unexplored: following such a restrictive dietary protocol can be very challenging on the long term. Nevertheless, benefits on mood, cognitive function and psychological aspects could be due to both disease-related improvements and ketones systemic mechanism of action.
The aim of this special issue is to investigate KD application in multiple fields beyond neurology. Emerging evidences are showing KD neuroprotective potential in conditions as Parkinson’s, Alzheimer’s, Amyotrophic lateral sclerosis, drug-resistant migraines, while antinflammatory and metabolic pathways are studied in cancer, obesity, cardiovascular diseases, polycystic ovary syndrome, but are not limited to this list.
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