Narrative Review of Surgery for Myasthenia Gravis
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Patrizia Longone, PhD
1. Head Molecular Neurobiology Unit Fondazione Santa Lucia Rome
2. Adjunct Professor of Physiology, Università degli Studi di Roma Tor Vergata, Rome, Italy
Research Interests: Amyotrophic lateral sclerosis; motor neurons; superoxide dismutase-1; neurobiology and brain physiology; neurodegenerative diseases
Ian Johnson, Ph.D., FRMS, FHEA, FRSB, C.Biol.
Professor of Anatomy, Department of Biomedical Sciences, Faculty of Medicine Health and Human Sciences, Macquarie University, NSW, Australia
Research Interests: Motor neurons; axotomy; nissl bodies; spinal cord; amyotrophic lateral sclerosis
About This Topic
Myasthenia gravis (MG) is a disease affecting neuromuscular transmission. Classically, it is attributed to autoantibodies directed to acetylcholine receptors (AChRs) at the neuromuscular junction, while more recent studies have highlighted the importance of autoantibodies directed against proteins involved in AchR clustering, such as muscle-specific tyrosine kinase or lipoprotein receptor-related protein 4.
Evidence is emerging, however, that this is not the whole story: MG is seldom an isolated disease, and in early onset MG in particular, patients have an increased risk of both concordant autoimmune diseases and comorbidities in general.
The special issue welcomes articles that focus on the various facets of MG and its comorbidities. Articles of any genre that help us understand the molecular and pathological interactions of comorbid conditions associated with MG, including their treatment and management, are specifically sought.
Manuscripts should be submitted online at http://www.lidsen.com/account-login by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. Guidelines for authors and other relevant information for submission of manuscripts are available on the Instructions for Authors page. OBM Neurobiology is an international peer-reviewed Open Access monthly journal published by LIDSEN. Please visit the Instructions for Authors page before submitting a manuscript.
Narrative Review of Surgery for Myasthenia Gravis
by Aaron Dezube , Ashley Deeb and Michael Jaklitsch
Received: 25 June 2021; Published: 15 October 2021; doi: 10.21926/obm.neurobiol.2104109
Myasthenia Gravis (MG) is a rare autoimmune disorder characterized by antibody mediated blockade of neuromuscular transmission. Up until the last decade, evidence suggesting benefit of thymectomy for myasthenia gravis has been based on non-randomized control studies. Our paper serves as an expert narrative review of new literature pertaining [...]
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