(ISSN 2573-4407)
OBM Neurobiology is an international peer-reviewed Open Access journal published quarterly online by LIDSEN Publishing Inc. By design, the scope of OBM Neurobiology is broad, so as to reflect the multidisciplinary nature of the field of Neurobiology that interfaces biology with the fundamental and clinical neurosciences. As such, OBM Neurobiology embraces rigorous multidisciplinary investigations into the form and function of neurons and glia that make up the nervous system, either individually or in ensemble, in health or disease. OBM Neurobiology welcomes original contributions that employ a combination of molecular, cellular, systems and behavioral approaches to report novel neuroanatomical, neuropharmacological, neurophysiological and neurobehavioral findings related to the following aspects of the nervous system: Signal Transduction and Neurotransmission; Neural Circuits and Systems Neurobiology; Nervous System Development and Aging; Neurobiology of Nervous System Diseases (e.g., Developmental Brain Disorders; Neurodegenerative Disorders).
OBM Neurobiology publishes a variety of article types (Original Research, Review, Communication, Opinion, Comment, Conference Report, Technical Note, Book Review, etc.). Although the OBM Neurobiology Editorial Board encourages authors to be succinct, there is no restriction on the length of the papers. Authors should present their results in as much detail as possible, as reviewers are encouraged to emphasize scientific rigor and reproducibility.
Publication Speed (median values for papers published in 2023): Submission to First Decision: 7.5 weeks; Submission to Acceptance: 15.9 weeks; Acceptance to Publication: 7 days (1-2 days of FREE language polishing included)
Special Issue
Metals and Neurodegeneration
Submission Deadline: December 31, 2021 (Closed) Submit Now
Guest Editor
Joy Mitra, PhD
Research Associate, Department of Neurosurgery, Center for Neuroregeneration, The Houston Methodist Research Institute, Houston, TX, United States
Research interests: Immunohistochemistry; In Situ Hybridization; Neuronal Differentiation; Immunofluorescence; Gene Expression; PCR
About This Topic
Metals play crucial roles in maintaining the normal physiological functions in human body. While metals are essentially required by the body’s immune response and other defense mechanisms against external and internal damaging insults. However, slight variation from the normal physiological concentration of metals, especially pro-oxidant transition metals, has been shown to play roles in disease causing patho-mechanisms by affecting the body’s overall metal homoeostasis. Decades of research has shown the implication of pro-oxidant metal dyshomoeostasis in almost all types neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis and so on. Notably, studies have shown that essential trace metals like zinc, iron etc., which are important for normal brain cell functioning, become toxic under the diseased condition, hence called ‘double-edged sword’, by inducing oxidative genome damage, cell membrane disruption, mitochondrial pathology and the most importantly facilitating pathogenic protein aggregate formation in neurons, leading to irreversible neuronal death by metal-associated death mechanism. Emerging findings have also highlighted the pro-oxidant metals’ role in developing post-stroke neuropathological complications and chronic dementia. Besides these negative impacts, metals play crucial roles in relaying electrical signals across the neuronal synapses and associated nerve cells, acting as co-factor for protein activity and as transcription factor as well. Although, recent investigations have been gradually shedding light on the feedback loop mechanism linking cellular stress levels and metal-induced toxicities, however, there is no effective therapeutic strategy to chelate out the disease-causing metal selectively and precisely from the affected cellular compartment only. Keeping these facts into account, it is of utmost importance to revisit the specific roles of metals in brain functions, understand the underlying cause which initiates metal dyshomeostasis, and how these conditions influence the alteration in neuronal gene expressions and inhibit the genome repair processes. In this special issue we will focus on the following aspects highlighting multifaceted roles of metal dyshomoeostasis in various neuropsychiatric and neurodegenerative disorders:
1) Introduction.
2) Role of metals in neuronal gene expressions and brain functions (motor and cognitive)
3) Metals in protective mechanisms in brain.
4) Metals in genome repair processes.
5) Involvement of pro-oxidant metals in neuropsychiatric, neurodegenerative and stroke pathologies.
6) Metal chelation therapy and its limitations.
7) Concluding assessment and suggestions for much needed improvements in chelation therapy.
Manuscript Submission Information
Manuscripts should be submitted through the LIDSEN Submission System. Detailed information on manuscript preparation and submission is available in the Instructions for Authors. All submitted articles will be thoroughly refereed through a single-blind peer-review process and will be processed following the Editorial Process and Quality Control policy. Upon acceptance, the article will be immediately published in a regular issue of the journal and will be listed together on the special issue website, with a label that the article belongs to the Special Issue. LIDSEN distributes articles under the Creative Commons Attribution (CC BY 4.0) License in an open-access model. The authors own the copyright to the article, and the article can be free to access, distribute, and reuse provided that the original work is correctly cited.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). Research articles and review articles are highly invited. Authors are encouraged to send the tentative title and abstract of the planned paper to the Editorial Office (neurobiology@lidsen.com) for record. If you have any questions, please do not hesitate to contact the Editorial Office.
Welcome your submission!
- Journal Metrics
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2023 
CiteScore SJR SNIP 1.0 0.232 0.256 - Newsletter
Vidhi is a Clinical yoga therapist; mentor for yoga therapy training in Krishnamacharya tradition. She holds a MSc in Public health from Kings College London.
Mirela Olympia Fagarasan Palmer
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Zhong-Ting (Justin) is a PhD student from Nanyang Technological University (Singapore). He holds BSc in Applied Chemistry and MSc in Environmental Engineering. He was a R&D researcher of NanoMaterials Technology Pte Ltd in Singapore (2006-2012). His current research interests are functional nanomaterials synthesis & design, and their application into environmental/chemical engineering. He has published near 60 SCI papers in Applied Catalysis B, Chemical Engineering Journal and so on with H-Index 23. He also serviced as reviewers over 40 Journals such as Appl. Catal. B, Water Research, Chem. Eng. J, ACS Applied Materials & Interface, etc. He was honored such as “The Bsic Research Achievment 1st Award of CIESC”, “The ZJUT Fund Breeding Distinguished Young Scholars” etc.
Rolf Teschke studied Medicine in Munich and Marburg, where he finished his MD thesis before starting a residency at the Department of Pathology, University of Marburg. Subsequently and with a fellowship of the Deutsche Forschungsgmeinschaft, he worked at the Bronx VA Hospital/Mount Sinai Hospital in New York during 1972–1975 together with Professor Charles S. Lieber and successfully isolated MEOS and expanded its characterization. Back in Germany, he was at the Heinrich-Heine University in Düsseldorf with a focus on alcoholic liver disease, biochemical drug studies, and clinical intoxications by halogenated aliphatic hydrocarbons, where he became a Professor of Medicine. In 1987, he was offered a chief position and appointed as Director of the Medical Department II, City Hospital Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt/Main. His clinical and research interests are on liver injury by drugs and herbs including causality assessment by RUCAM in close association with Dr. Gaby Danan in Paris. A perfect cooperation exists also with Professor Tran Dang Xuan of the University of Hiroshima, Japan. Finally, he is the author of more than 275 publications including books and book chapters, and he is editor in chief of scientific journals and member of editorial boards.