OBM Neurobiology is an international peer-reviewed Open Access journal published quarterly online by LIDSEN Publishing Inc. By design, the scope of OBM Neurobiology is broad, so as to reflect the multidisciplinary nature of the field of Neurobiology that interfaces biology with the fundamental and clinical neurosciences. As such, OBM Neurobiology embraces rigorous multidisciplinary investigations into the form and function of neurons and glia that make up the nervous system, either individually or in ensemble, in health or disease. OBM Neurobiology welcomes original contributions that employ a combination of molecular, cellular, systems and behavioral approaches to report novel neuroanatomical, neuropharmacological, neurophysiological and neurobehavioral findings related to the following aspects of the nervous system: Signal Transduction and Neurotransmission; Neural Circuits and Systems Neurobiology; Nervous System Development and Aging; Neurobiology of Nervous System Diseases (e.g., Developmental Brain Disorders; Neurodegenerative Disorders).
OBM Neurobiology publishes research articles, technical reports and invited topical reviews. Although the OBM Neurobiology Editorial Board encourages authors to be succinct, there is no restriction on the length of the papers. Authors should present their results in as much detail as possible, as reviewers are encouraged to emphasize scientific rigor and reproducibility.
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Rapid publication: manuscripts are undertaken in 11.8 days from acceptance to publication (median values for papers published in this journal in the second half of 2021, 1-2 days of FREE language polishing time is also included in this period).
Autoradiography: Past and Emerging Technologies to Map Receptors/Enzymes and Their Functions
Submission Deadline: December 31, 2022 (Open) Submit Now
Najam Sharif, PhD, DSc
Global Alliance and External Research, Santen Inc., Emeryville, CA 94608, USA.
Adjunct Professor, University of North Texas (USA), Duke-NUS Medical School (Singapore).
Research interests: neurological diseases; therapeutics; retina and brain connections; glaucomatous optic neuropathy; optic nerve; pharmacology; drug discovery.
About This Topic
Use of radioligands to display and evaluate their binding sites within body cells and tissues has a rich history from simply mapping the presence of receptors/enzymes/transporters to use as diagnostic agents. Since significant technological advances have occurred over the last 3-4 decades, it is important to capture and disseminate the wealth of knowledge that has accumulated. Techniques and tools ranging from digital subtraction quantitative methods, pharmacological evaluation of compounds in un-dissectible cells/tissues, phosphor imaging, generation and utility of novel radioisotopes for imaging, imaging of receptor function in response to drugs and transmitters in vitro, and functional imaging in living animals and humans using positron emission tomography have evolved that can shed light on normal vs diseased conditions and reveal drug delivery challenges and solutions and provide insights to side-effect potential of drugs. Receptor/enzyme localization is critical for verifying target engagement in cells and tissues impacting different body organs but in particular the brain, spinal cord, optic nerve and retina, areas of focus of this Special Issue. Authors working in these fields of study are encouraged to submit their original research papers or review articles with emphasis on tissues and organs mentioned above.
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