A Systematic Review of the Biological Processes Involved in Deep-Brain Stimulation for Parkinson's disease: A Focus on the Potential Disease-Modifying Effects
OBM Neurobiology is an international peer-reviewed Open Access journal published quarterly online by LIDSEN Publishing Inc. By design, the scope of OBM Neurobiology is broad, so as to reflect the multidisciplinary nature of the field of Neurobiology that interfaces biology with the fundamental and clinical neurosciences. As such, OBM Neurobiology embraces rigorous multidisciplinary investigations into the form and function of neurons and glia that make up the nervous system, either individually or in ensemble, in health or disease. OBM Neurobiology welcomes original contributions that employ a combination of molecular, cellular, systems and behavioral approaches to report novel neuroanatomical, neuropharmacological, neurophysiological and neurobehavioral findings related to the following aspects of the nervous system: Signal Transduction and Neurotransmission; Neural Circuits and Systems Neurobiology; Nervous System Development and Aging; Neurobiology of Nervous System Diseases (e.g., Developmental Brain Disorders; Neurodegenerative Disorders).
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Deep Brain Stimulation for Neurobiology Diseases
Submission Deadline: December 31, 2020 (Open) Submit Now
Lilach Soreq, PhD
Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
Research Interests: Gene Expression; Neuroscience; Molecular Biology; Neurodegenerative Diseases; Bioinformatics and Computational Biology
About This Topic
Parkinson’s disease (PD) is an age related devastative neurodegenerative disease. Upon diagnosis almost all the dopaminergic neurons in the brain are already diminished. Deep Brain stimulation (DBS) treatment significantly elevates the disease symptoms including tremor. Recently RNA expression profiles were characterized in PD blood leukocytes prior to and following DBS including both microRNAs and long non coding RNAs through exon and junction microarrays as well as RNA sequencing. Computational analyses revealed significantly changes genes as well as altered molecular pathways. Hierarchical classification allows classification of detected genes by expression levels. The changes included neuro-inflammatory and alternative splicing changes. Non parametric statistics allow identification of further altered gene ontology pathways. Finally, comparison to MPTP treated PD mice models revealed further common changes including in ion channels.
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Title: Electrophysiological properties of posteromedial hypothalamus
Authors: Lorena Vega-Zelaya 1, Elena Martín-Abad 2, Cristina V. Torres 3, Marta Navas 4 and Jesús Pastor 5, *
Abstract: Pathological aggressiveness is an invalidating condition that can be successfully treated by deep brain stimulation (DBS) at posteromedial hypothalamus (PMH). Although some reports are published about electrophysiological properties of this nucleus, a systematic and comprehensive description lacks. We plan to analyze the electrophysiological properties of PMH and surrounded structures of patients treated by DBS and targeted by microelectrode recording (MER) and neurophysiological testing along the trajectories. The optimal target for SBS is defined by the response to electrical stimulation (Hernando et al, 2008). The aim of our study will be to characterize the neurophysiological properties of PMH, namely, the properties of the action potential morphology, mean frequency of the discharge, density of the neurons, and tonic and phasic properties of the discharge (Vega-Zelaya et al, 2019) in well-defined placed along trajectories defined by the clinical response to electrical stimulation.
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