Special Issue
On the Role of Early-life Neuroinflammation in Neuropsychiatric Disorders
Submission Deadline: December 30, 2018 (Closed)
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Guest Editor
Jenny Berrío, MD, MSc
PPG-Ciências da reabilitação, Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite, 245, Porto Alegre, Brazil
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Research Interests: Behavior; Cognition: Models, animal, Neurodegenerative diseases; Neuronal plasticity; neuro-immune interactions
Co-Editor
Bart Ellenbroek, PhD
Professor and Deputy Head of School, School of Psychology, Victoria University of Wellington, PO Box 600, Wellington 6140, New Zealand
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Research Interests: animal models; schizophrenia; gene-environment interactions; drug addiction; autism; dopamine; serotonin; behavior
About This Topic
Immune homeostasis within the brain is of special importance for its adequate functioning, thus not surprisingly, any breach of this balance can lead to impaired brain activity. Recent research has identified dysregulated neuroinflammation as a contributing factor in the vulnerability to and development of several neuropsychiatric disorders. In addition to autism and schizophrenia, anxiety and depression, as well as dementia, have now been linked to excessive inflammation of the brain. Particularly, an inappropriate inflammatory response during early-life has been consistently associated with an elevated susceptibility. It has long been known that early-life experiences have the capacity to alter brain development. By changing the long-term function of the immune system, which in turn influences brain function, early-life events have the potential to modify, in the long-term, how the brain is shaped and how it responds to other environmental challenges. The aim of this special issue is to publish up-to-date scientific literature on the topic, deepening the understanding of the complex mechanisms through which this brain-immune connection stresses out our mental health. Original research reports, review articles, communications, and perspectives are welcome in all areas pertinent to the topic. All accepted papers will be published totally free of charge.
Planned Papers
Title: Temporal Lobe Epilepsy, Stroke, and Traumatic Brain Injury: Mechanisms of Hyperpolarized, Depolarized, and Flow-through Ion Channels Utilized as Tri-Coordinate Biomarkers of Electrophysiologic Dysfunction
Authors: Gina Sizemore1, Brandon Lucke-Wold2, Charles Rosen2, James W. Simpkins3, Sanjay Bhatia2, Dandan Sun4
Affiliation:
1.Department of Clinical and Translational Science, West Virginia School of Medicine, Morgantown, WV
2.Department of Neurosurgery, West Virginia School of Medicine, Morgantown, WV
3.Center for Basic and Translational Stroke Research, West Virginia School of Medicine, Morgantown, WV
4.Department of Neurology, University of Pittsburgh, Pittsburgh, PA
Title: Possible roles of transglutaminase 2 in the molecular mechanisms responsible for human neuropsychiatric disorders.
Authors: Nicola Gaetano Gatta, Elenamaria Fioretti and Vittorio Gentile*
Affiliation: Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, via Costantinopoli 16, 80138 Naples, Italy.
Abstract: Transglutaminases are a family of Ca2+-dependent enzymes which catalyze post-translational modifications of proteins. The main activity of these enzymes is the cross-linking of glutaminyl residues of a protein/peptide substrate to lysyl residues of a protein/peptide co-substrate. In addition to lysyl residues, other second nucleophilic co-substrates may include monoamines or polyamines (to form mono- or bi-substituted/crosslinked adducts) or –OH groups (to form ester linkages). In absence of co-substrates, the nucleophile may be water, resulting in the net deamidation of the glutaminyl residue. Transglutaminase activity has been suggested to be involved in molecular mechanisms responsible for both physiological and pathological processes, including inflammation. In particular, transglutaminase 2, a member of the transglutaminase family, has been shown to be responsible for human autoimmune diseases, and Celiac Disease is just one of them. Interestingly, neurodegenerative diseases, such as Alzheimer’s Diseases, Parkinson’s Diseases, supranuclear palsy, Huntington’s Diseases and other polyglutamine diseases, are characterized in part by aberrant cerebral transglutaminase activity and by increased cross-linked proteins in affected brains. In this review we will focus on the possible molecular mechanisms by which this enzyme could be responsible for such diseases and the possible use of transglutaminase inhibitors for patients with neuropsychiatric diseases characterized by aberrant transglutaminase activity.
Title: Vascular plasticity involving AT1 receptors in the amphetamine-induced inflammatory scenario: relevance to animal models of psychiatric disorders.
Authors: Natalia Andrea Marchese 1, Victoria Belén Occhieppo 1, Osvaldo Martin Basmadjian 1, Ana De Paul 2, Gustavo Baiardi 3 and Claudia Bregonzio 1,*
Affiliation:
1. Instituto de Farmacología Experimental Córdoba (IFEC-CONICET) Departamento de Farmacología. Facultad de Ciencias Químicas Universidad Nacional de Córdoba. Córdoba, Argentina
2. Instituto de Investigaciones en Ciencias de la Salud (INICSA- CONICET). Centro de Microscopía Electrónica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba. Córdoba, Argentina
3. Laboratorio de Neurofarmacología, (IIBYT-CONICET) Universidad Nacional de Córdoba Facultad de Ciencias Químicas, Universidad Católica de Córdoba, Córdoba, Argentina
Abstract:
Amphetamine exposure is validated as a pharmacological tool to model several psychiatric diseases, such as the dopaminergic/glutamatergic imbalance in schizophrenia and mania. However, its effects extend beyond neurotransmission, as psychostimulant exposure has been associated to brain vascular damage and neuroinflammation. AT1 receptors (AT1-R) are implicated in brain micro-vascular physiological responses; whereas their over-expression is related to inflammatory mediators release, oxidative damage, and endothelial dysfunction in pathological conditions. In the present work, we aimed to evaluate amphetamine effects in main brain arteries, and to elucidate AT1-R role in amphetamine-induce alterations in brain micro-vessels. Male adult Wistar rats received amphetamine (2.5mg/kg-i.p., 5 days) and one week later main brain arteries and cerebral-spinal fluid were sampled to assess inflammatory markers. To evaluate AT1-R involvement in amphetamine-induced alterations in brain micro-vessels, AT1-R antagonist (Candesartan; 3mg/kg-p.o., days 1–5) was administered previous to amphetamine administration (days 6–10). One week later (day 17) AT1-R expression at basal conditions and cellular stress after a challenge (angiotensin-II or cold) were assessed. Two-way-ANOVA and Bonferroni test were used. Amphetamine modified carotid structure and increased AT1-R and intercellular-adhesion-molecule-1 expression in middle cerebral artery. Moreover, in cerebral-spinal fluid TNF-α and IL-6 levels were increased after a challenge. In brain micro-vessels, amphetamine increased AT1-R expression and exacerbated heat-shock-protein-70 levels after a challenge. AT1-R blockade prevented AT1-R up-regulation and the sensitized cellular stress responses. Our results stand out vascular plasticity, involving AT1-R, under amphetamine-induced pro-inflammatory conditions.
Title: Does early compositional changes to microflora promote central neuroinflammation in autism?
Authors: Daniel K Goyal 1, Anton Emmanuel 2
Affiliations:
1. Neurosciences Department, University of Manchester, Manchester, England
2. Neurogastroenterology (TBC), University College London, London, United Kingdom
Title: Inflammation in neuronally derived exosomes on psychological outcomes following traumatic brain injury
Authors: Cassandra L Pattinson 1, André van der Merwe 2, Sara Lippa 2, Leighton Chan 2,3,†, Jessica M Gill 1,3,†
Affiliation:
1. National Institute of Nursing Research, National Institutes of Health, Bethesda, MD
2. National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD
3. Center for Neuroscience and Regenerative Medicine (CNRM), Uniformed Services University, Bethesda, MD.
† Co-senior authors
Title: Autoantibodies against cerebellar neurons and phosphatidylethanolamine binding protein-1 in a paediatric patient with stiff-person syndrome and autoimmune polyendocrinopathy type 1
Authors: Carmen Schröder, Natalie Bachmaier, Timothy Howell, Heinz Lauffer, Roman Legrand, Philippe Chan, David Vaudry, Maria Hamze-Sinno, Marie François, Pierre Déchelotte, Tomas Hökfelt, Sergueï O. Fetissov
Abstract：
Stiff-person-syndrome (SPS) is commonly related to autoantibodies against glutamic acid decarboxylase (GAD). Here, putative brain autoantibody targets were studied in GAD autoantibody negative 11-years-old boy with SPS and autoimmune polyendocrine syndrome type 1. We found that at the peak of SPS symptoms, IgG from both patient’s serum and cerebrospinal fluid immunostained cerebellar Golgi cells and neuronal fibers. Using proteomics, phosphatidylethanolamine-binding protein-1 has been identified as the putative autoantigen in the cerebellum. These results show that an unusual case of SPS can be associated with autoimmunity against phosphatidylethanolamine-binding protein-1 and specific brain targets.
Title: Childhood Metabolic and Immune Diseases Determine the Onset of Mood Disorders
Authors: Diana Manzano, Inés Corraliza
Affiliation: Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, University of Extremadura, Cáceres, Spain
Manuscript Submission Information
Manuscripts should be submitted through the LIDSEN Submission System. Detailed information on manuscript preparation and submission is available in the Instructions for Authors. All submitted articles will be thoroughly refereed through a single-blind peer-review process and will be processed following the Editorial Process and Quality Control policy. Upon acceptance, the article will be immediately published in a regular issue of the journal and will be listed together on the special issue website, with a label that the article belongs to the Special Issue. LIDSEN distributes articles under the Creative Commons Attribution (CC BY 4.0) License in an open-access model. The authors own the copyright to the article, and the article can be free to access, distribute, and reuse provided that the original work is correctly cited.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). Research articles and review articles are highly invited. Authors are encouraged to send the tentative title and abstract of the planned paper to the Editorial Office (neurobiology@lidsen.com) for record. If you have any questions, please do not hesitate to contact the Editorial Office.
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Publication
Open Access
Research Article
Abstract
Research into the effects of microflora on health and in disease has increased recently. Such enthusiasm seems well placed. Should the preliminary studies translate through the larger, more powerful studies, the medical community may well have an entirely new platform from which to intervene for health and against disease. Delineating [...]
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Abstract
A number of studies have highlighted the connection between infections during pregnancy in mothers and increased risk for neuropsychiatric disorders later in life leading to the view that maternal immune activation is a significant contributor to psychiatric illnesses. Meta-analyses have revealed associations between the incidence of prematur [...]
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Abstract
Inflammation and immune responses after stroke including ischemic cerebral infarction play pivotal roles in the pathology, resolution of inflammation, and neurological recovery. Regulatory T (Treg) cells are the cells responsible for immune tolerance, usually activated by secondary lymphatic tissues, which subsequently regulate effector T [...]
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Vidhi is a Clinical yoga therapist; mentor for yoga therapy training in Krishnamacharya tradition. She holds a MSc in Public health from Kings College London.
Mirela Olympia Fagarasan Palmer
Luigi Fontana, MD, PhD.jpg)
Zhong-Ting (Justin) is a PhD student from Nanyang Technological University (Singapore). He holds BSc in Applied Chemistry and MSc in Environmental Engineering. He was a R&D researcher of NanoMaterials Technology Pte Ltd in Singapore (2006-2012). His current research interests are functional nanomaterials synthesis & design, and their application into environmental/chemical engineering. He has published near 60 SCI papers in Applied Catalysis B, Chemical Engineering Journal and so on with H-Index 23. He also serviced as reviewers over 40 Journals such as Appl. Catal. B, Water Research, Chem. Eng. J, ACS Applied Materials & Interface, etc. He was honored such as “The Bsic Research Achievment 1st Award of CIESC”, “The ZJUT Fund Breeding Distinguished Young Scholars” etc.
Rolf Teschke studied Medicine in Munich and Marburg, where he finished his MD thesis before starting a residency at the Department of Pathology, University of Marburg. Subsequently and with a fellowship of the Deutsche Forschungsgmeinschaft, he worked at the Bronx VA Hospital/Mount Sinai Hospital in New York during 1972–1975 together with Professor Charles S. Lieber and successfully isolated MEOS and expanded its characterization. Back in Germany, he was at the Heinrich-Heine University in Düsseldorf with a focus on alcoholic liver disease, biochemical drug studies, and clinical intoxications by halogenated aliphatic hydrocarbons, where he became a Professor of Medicine. In 1987, he was offered a chief position and appointed as Director of the Medical Department II, City Hospital Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt/Main. His clinical and research interests are on liver injury by drugs and herbs including causality assessment by RUCAM in close association with Dr. Gaby Danan in Paris. A perfect cooperation exists also with Professor Tran Dang Xuan of the University of Hiroshima, Japan. Finally, he is the author of more than 275 publications including books and book chapters, and he is editor in chief of scientific journals and member of editorial boards.