04 - LIDSEN Publishing Inc.丨The Open Access Publisher

Volume 8,Issue 4

Open Access Original Research

A Phase I/II Randomized Trial of Higher Dose mRNA-1273 Boosters in Lung Transplant Recipients

Michael Y. Shino ,

Francisco Javier Ibarrondo ,

Jesse L. Clark ,

Adreanne Rivera ,

Marlene Florian ,

Allison Ramsey ,

Ariss Derhovanessian ,

Rajan Saggar ,

Olawale O. Amubieya ,

Grant Turner ,

Joanna M. Schaenman ,

Pryce T. Gaynor ,

Omer E. Beaird ,

Ashrit Multani ,

Reshma M. Biniwale ,

Murray H. Kwon ,

Christos J. Petropoulos ,

Yolanda Lie ,

Terri Wrin ,

Amparo L. Figueroa ,

Brett Leav ,

Zelalem Endale ,

Kate Anteyi ,

Jacqueline M. Miller ,

Abbas Ardehali ,

David M. Sayah ,

David Elashoff ,

John A. Belperio ,

Otto O. Yang and

S. Sam Weigt

Received: 16 August 2024; Published: 20 November 2024; doi: 10.21926/obm.transplant.2404227

Abstract

Higher-dose mRNA booster vaccines have not been well studied for transplant recipients. This study evaluated the safety, reactogenicity and immunogenicity of higher dose mRNA-1273 booster vaccines among lung transplant recipients (LTRs). This phase 1/2 open-label randomized clinical trial of higher-dose mRNA-1273 booster vaccination enrolled nineteen adult LTRs into the 50 ug (n=8) vs. 100 ug (n=11) groups before enrollment was terminated due to the availability of the bivalent mRNA-1273.222 vac [...]

Open Access Research Article

Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Fanconi Anemia: Results of a Single Center with a Fludarabine-Based Conditioning Regimen

Sabrine Mekni ,

Lamia Torjemane ,

Malek Khayati ,

Dorra Belloumi ,

Rimmel Yosra Kanoun ,

Insaf Ben Yaiche ,

Rihab Ouerghi ,

Ines Turki ,

Saloua Ladeb ,

Tarek Ben Othman and

Nour Ben Abdeljelil

Received: 29 June 2024; Published: 11 November 2024; doi: 10.21926/obm.transplant.2404226

Abstract

Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) remains the only curative treatment for bone marrow failure (BMF) and hematologic complications of Fanconi anemia (FA). The evolution remains affected by the toxicity, the risk of graft failure, and clonal evolution. This study aimed to identify factors affecting outcomes in FA patients after allo-HSCT. We included FA patients who underwent allo-HSCT between January 2006 a [...]

Open Access Case Report

Use of Plasma-Rich in Growth Factors (PRGF) in the Treatment of Acne

Elga J. Vargas ,

Julio C. Martinez and

Lina A. Gomez

Received: 26 April 2024; Published: 03 October 2024; doi: 10.21926/obm.transplant.2404225

Abstract

Acne is a chronic inflammatory condition affecting the pilosebaceous units of the skin, characterized by the formation of papules, cysts, comedones, pustules, nodules, and scars. These lesions are typically located on the face and shoulders, although they can extend to the trunk, arms, and legs. In regenerative medicine, biomolecules are fundamental to tissue regeneration. The use of growth factors from autologous platelet-rich plasma emerges as a promising alternative in the treatment of acne a [...]

Table of Contents

A Phase I/II Randomized Trial of Higher Dose mRNA-1273 Boosters in Lung Transplant Recipients

Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Fanconi Anemia: Results of a Single Center with a Fludarabine-Based Conditioning Regimen

Use of Plasma-Rich in Growth Factors (PRGF) in the Treatment of Acne