OBM Transplantation (ISSN 2577-5820) is an international peer-reviewed Open Access journal published quarterly online by LIDSEN Publishing Inc., which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.
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Extracorporeal Photopheresis in Graft-versus-Host Disease (GVHD)
Submission Deadline: August 15, 2024 (Open) Submit Now
Swati Pabbi, MD
Department of Transfusion Medicine and Immunohematology, Medanta-The Medicity, Gurgaon
Research Interests: Plasmapheresis; Cascade plasmapheresis; Immunoadsorption; Stem cell harvests; Extracorporeal photopheresis for GVHD and transplant immunology
Steven Potter, MD, FACS
Professor of Surgery and Urology, Director, Pancreas Transplantation, Medstar Georgetown Transplant Institute, Georgetown University School of Medicine, Chair, ASTS
Research Interests: Renal transplantation; Pancreas transplantation; Living kidney donation; Transplant immunosuppression; Urology; Urologic oncology
About This Topic
Extracorporeal photopheresis (ECP) is an immunomodulatory therapy in which leukocytes are collected by apheresis and subsequently exposed to ultraviolet-A (UVA) irradiation in the presence of a photosensitizing agent, 8-methoxypsoralen and reinfused back to the patient.
ECP was first used and approved by FDA for patients suffering from sezary syndrome (cutaneous-T cell lymphoma (CTCL). It has also been found to be beneficial in graft versus host disease (GVHD) following hematopoietic stem cell transplant (HSCT), solid organ transplant and various autoimmune diseases.
GvHD is a is a major cause of morbidity and mortality following allogeneic HSCT. Corticosteroids are the first line therapy but only 50-60% patients respond. Multiple second-line treatments are associated with several side effects, such as profound systemic immunosuppression with an increased risk of infection or disease relapse. ECP in the absence of severe systemic immunosuppression has been proven to be safe and beneficial treatment modality for steroid-refractory GvHD. There is limited literature and studies to establish the preventive role of ECP in GVHD. This special issue would help to contribute in various aspects of ECP mainly centred around collection methods, patient selection and eligibility criteria, category of patients who would benefit, role of leukocyte count on the efficacy of ECP therapy in GVHD. Original research articles, review of literature and short commentaries are welcomed.
Manuscript Submission Information
Manuscripts should be submitted through the LIDSEN Submission System. Detailed information on manuscript preparation and submission is available in the Instructions for Authors. All submitted articles will be thoroughly refereed through a single-blind peer-review process and will be processed following the Editorial Process and Quality Control policy. Upon acceptance, the article will be immediately published in a regular issue of the journal and will be listed together on the special issue website, with a label that the article belongs to the Special Issue. LIDSEN distributes articles under the Creative Commons Attribution (CC BY 4.0) License in an open-access model. The authors own the copyright to the article, and the article can be free to access, distribute, and reuse provided that the original work is correctly cited.
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