Open Access Communication

Calculated Human Leucocyte Antigens Evolutionary Divergence (cHED)

Received: 15 December 2023;  Published: 11 March 2024;  doi: 10.21926/obm.transplant.2401208


Human Leucocyte Antigens (HLA) constitute a highly polymorphic set of genes pivotal to the immune response. The HLA heterozygous advantage hypothesis assumes that heterozygous individuals at the HLA level have a wider range of peptides for T cell recognition than homozygous individuals. Consequently, they possess an enhanced capacity to trigge [...]