OBM Transplantation is an international peer-reviewed Open Access journal, which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.
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Complications and Management of Kidney Transplantation: Focus on Infection
Submission Deadline: October 31, 2022 (Open) Submit Now
Deborah B. Adey, MD, Professor of Medicine
University of California, San Francisco, San Francisco, United States
Research Interests: Kidney Transplantation; Infections in kidney transplantation; Long term management kidney transplantation
About This Topic
Management of solid organ transplant recipients is always an exercise in finding the right balance of immunosuppression, which can pose a significant challenge. Under immunosuppression risks organ rejection while over immunosuppression puts the recipient at risk for infection or malignancy. The risk for infectious complications post-kidney transplantation is dependent upon several factors including organ donor exposures (living or deceased), recipient exposures, surgical issues, geography, timing since transplant, and patient immunosuppression. Viral and fungal infections are common amongst transplant recipients due to the nature of T-cell focused immunosuppression in organ transplantation. However, a broad net of suspicion should be cast as transplant recipients are likely to have atypical presentations with atypical organisms. Management of the transplant recipient with infection can be complicated and needs to take into consideration the nature of the immunosuppression, the overall risks of immunosuppression reduction, drug interactions with immunosuppression agents, and duration of therapy. Successful management of infections in kidney transplant recipients requires a multidisciplinary approach to diagnosis and management.
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