OBM Transplantation is an international peer-reviewed Open Access journal, which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.
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We welcome original clinical studies as well as basic science, reviews, short reports/rapid communications, case reports, opinions, technical notes, book reviews as well as letters to the editor.
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Allogenic Stem Cell Transplantation
Submission Deadline: December 15, 2021 (Open) Submit Now
Yvonne A. Efebera, MD, MPH
Professor, Blood and Marrow Transplantation Program, Ohio State University, Columbus, Ohio, USA
Research Interests: Multiple myeloma; graft vs host disease; paraproteinemias; amyloidosis; necrobiotic xanthogranuloma; blood and marrow transplantation
Nidhi Sharma, PhD
Internal Medicine, Division of Hematology, Ohio State University, Columbus, OH, USA
Research Interest: Graft vs host disease (GVHD); allogenic stem cell transplantation; autologous stem cell transplantation; stem cell transplantation
About This Topic
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is increasingly used for patients with hematological malignancies. In particular, allogenic hematopoietic stem cell transplantation (allo-HSCT) is increasingly used for patients with high-risk leukemia’s and refractory lymphomas. The success of this is based on immune-based graft versus leukemia effect caused by donor T cells. Donor T-cells, however, are also the cause of graft versus host disease (GVHD). GVHD remains a leading cause of morbidity and mortality in allogeneic hematopoietic stem marrow transplant (allo-HSCT), with rates ranging from 25% to 68%. In addition, it is often impeded by several factors including relapse of the underlying disease, and infectious complications. Hence, the practice of allo-SCT is continuously evolving to mitigate these factors. In particular, advances in the conditioning regimens, GVHD prophylaxis, infectious disease monitoring and prophylaxis and supportive care not only have resulted in improved outcomes, but also have expanded potential indications for allo-HSCT. Given the rapidly evolving treatment scenario and promising findings, allo-SCT holds the potential for better survival outcomes for patients with hematological malignancies. Here we welcome papers outlining the role and new advancements in allogenic transplantation in the treatment of hematological malignancies.
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