OBM Transplantation is an international peer-reviewed Open Access journal, which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.
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Antibody Mediated Rejection in Organ Transplantation
Submission Deadline: September 30, 2019 (Open) Submit Now
Ignatius Tang, MD, PharmD, FASN, FAST, FACP
Associate Professor of Clinical Medicine, Medical Director, Kidney, Pancreas and Islet Transplant Programs, Director, Live Donor Kidney Transplant Program, Section of Nephrology, Department of Medicine, University of Illinois Medical Center at Chicago, 820 South Wood Street, M/C 793, Chicago, IL 60612, USA
Research Interests: Antibody-mediated syndromes (antibody-mediated rejection, accommodation, transplant glomerulopathy); BK viral kinetics and immunosuppression; outcomes of obese kidney transplant recepients
About This Topic
Organ transplantation is a curative therapy for hundreds of thousands of patients with end-stage organ failure. However, long-term outcomes have not improved, and nearly half of transplant recipients will lose their allografts by 10 years after transplant. One of the major challenges facing clinical transplantation is antibody-mediated rejection (AMR) caused by anti-donor HLA antibodies.
Antibody mediated rejection (AMR) poses a significant and continued challenge for long term graft survival in organ transplantation. However, in the recent years, there has emerged an increased understanding of the varied manifestations of the antibody mediated processes in organ transplantation.
This special issue aims to describe the clinical and histological manifestations of AMR, and discusses the immunopathological mechanisms contributing to antibody-mediated allograft injury as well as current and emerging therapies.
Received: 22 August 2020; Published: 28 September 2020; doi: 10.21926/obm.transplant.2003119
This article reviews the current treatment strategies of antibody-mediated rejection in kidney transplantation, which is increasingly recognized as the leading immunological cause of graft failure. The pathophysiologic complexity of this condition poses significant challenges for its treatment; however, progress toward advancing our understand [...]
Eplet-Based HLA Class II Matching for Transplantation: Design of a Repertoire of Interlocus Eplets Shared between HLA-DR, -DQ and -DP Alleles
Received: 13 December 2019; Published: 10 February 2020; doi: 10.21926/obm.transplant.2001099
Many studies have demonstrated that HLA-DR, HLA-DQ and HLA-DP matching at the eplet level reduces allograft rejection and improves transplant outcome. Such studies have examined the eplet effect for the individual class II loci, but until now little attention has been given to so-called interlocus class II eplets shared between HLA-DR, HLA [...]
Therapeutic Apheresis in Prevention and Treatment of Antibody-Mediated Rejection of Renal Allografts
Received: 13 October 2019; Published: 02 December 2019; doi: 10.21926/obm.transplant.1904093
Antibody-mediated rejection represents a significant barrier to favourable long-term outcomes after kidney transplantation and is the most common cause of allograft failure. Therapeutic apheresis techniques associated with other treatments, such as immunosuppressive drugs, are commonly used in the prevention and treatment of antibody-mediated [...]
Alemtuzumab Treatment Leads to Delayed Recovery of T Follicular Regulatory Cells, and May Therefore Predispose Patients to de novo Donor-Specific Antibody Formation
Received: 02 June 2019; Published: 19 August 2019; doi: 10.21926/obm.transplant.1903079
Background - T follicular helper (Tfh) and regulatory (Tfr) cells are key players in the formation of long-lived antibody responses. Their circulating counterparts, cTfh and cTfr, are often used as biomarkers because longitudinal sampling of secondary lymphoid tissues is unfeasible in clinical studies. This is the first study to track cTfh [...]
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