Circulating lncRNAs HOTTIP and HOTAIR as Potential Biomarkers in Crigler-Najjar Syndrome: A Preliminary Report from Shiraz Liver Transplant Research Center
Abstract
(ISSN 2577-5820)
OBM Transplantation (ISSN 2577-5820) is an international peer-reviewed Open Access journal published quarterly online by LIDSEN Publishing Inc., which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.
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Special Issue
Diagnostic Requirements Including Algorithms and Biomarkers in Liver Transplantation
Submission Deadline: January 31, 2025 (Open) Submit Now
Guest Editor
Rolf Teschke, MD, Professor (Biography)
1. Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Hanau, Germany
2. Academic Teaching Hospital of the Medical Faculty, Goethe University Frankfurt/Main, Frankfurt/Main, Germany
Research Interests: Hepatology; herbal hepatotoxicity; gastroenterology; alcoholic liver disease
About This Topic
Liver transplantation (LT) is an important life-saving option for patients with acute liver failure, complications of end-stage liver diseases like cirrhosis, and stage T2 hepatocellular carcinoma. Currently, the survival rates are 90% after 1 year and 70% after 5 years. Of importance are careful evaluation of candidates regarding indications and contraindications. Despite major diagnostic efforts, the causes of the liver diseases of published reports on LTs often remain unclear. To overcome these issues, it is mandatory to improve the diagnostic approaches to liver diseases. This is best done by using validated diagnostic causality algorithms combined with validated diagnostic biomarkers.
Keywords
Liver transplantation; end-stage liver diseases; cirrhosis; hepatocellular carcinoma; diagnostic causality algorithms; diagnostic biomarkers
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Publication
Circulating lncRNAs HOTTIP and HOTAIR as Potential Biomarkers in Crigler-Najjar Syndrome: A Preliminary Report from Shiraz Liver Transplant Research Centerby
Nasrin Motazedian
,
Masoud Mokhtari
,
Negar Azarpira
,
Kimia Falamarzi
,
Mohsen Mohammadi
,
Seyed Mohsen Dehghani
,
Sarina Pourjafar
,
Maryam Ataollahi
,
Elaheh Esfandiari
,
Mahdokht Hossein-Aghdaie
,
Seyed Ali Malekhosseini
,
Tayebeh Kazemi
and
Mahintaj Dara
Abstract Crigler-Najjar syndrome (CNS) is a rare autosomal recessive disorder characterized by impaired bilirubin metabolism, leading to neurotoxic unconjugated bilirubin accumulation. Liver transplantation remains the only effective treatment, highlighting the need for novel diagnostic and therapeutic approaches. Long non-coding RNAs [...] |
2023 | ||
CiteScore | SJR | SNIP |
0.6 | 0.179 | 0.17 |
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