by Kimberly Bader  , James J. Lah  , Allan I. Levey  , Greg J. Esper  , Whitney Wharton  and Joe R. Nocera

Received: 27 December 2021;  Published: 08 September 2022;  doi: 10.21926/obm.geriatr.2203203

Individuals with Alzheimer’s disease (AD) and Mild Cognitive Impairment (MCI) have increased gait disturbances throughout disease progression. However, an understanding of gait impairment and progression in early versus late AD is lacking. Further, the longitudinal progression of gait impairment in AD as well as in those with MCI that transition to AD is lacking. Understanding gait pathology and progression of gait impairment is critical for implementation of strategies that could limit the high prevalence of gait [...]

by Zsuzsanna M. Schmidt  and Gyula Poor

Received: 07 May 2022;  Published: 27 July 2022;  doi: 10.21926/obm.geriatr.2203202

Polymyalgia rheumatica (PMR) is an age-related chronic inflammatory disease with rheumatic features at the fore. In addition to the high-grade systemic inflammation, it is characterized by typical “polymyalgic” musculoskeletal symptoms, including diffuse and severe pain and prolonged morning stiffness of the shoulder girdle, pelvic girdle, and neck. PMR is a member of the so-called giant cell arteritis complex; however, in spite of the marked systemic inflammation in PMR, the local vasculitis process aborts. The pa [...]

by OBM Geriatrics Editorial Office

Received: 01 July 2022;  Published: 03 July 2022;  doi: 10.21926/obm.geriatr.2203201

by Giuseppe Cocco  and Stefano Pandolfi

Received: 07 February 2022;  Published: 16 June 2022;  doi: 10.21926/obm.geriatr.2202200

Syncope is characterized by a transient and rapid loss of consciousness for a short duration, with full spontaneous recovery within minutes. Syncope causes up to 2% of all emergency medical consultations. The incidence of syncope is similar in men and women, is higher in old patients (slightly higher in old women). The prevalence of syncope is up to 23% for the institutionalized elderly. In elderly patients, syncope often presents atypically, such as with falls; these patients might also have difficulty recalling e [...]

by OBM Geriatrics Editorial Office

Received: 01 June 2022;  Published: 09 June 2022;  doi: 10.21926/obm.geriatr.2202199

InterviewAn Interview with Dr. Carlo PedrolliOBM Geriatrics Editorial OfficeLIDSEN Publishing Inc., 2000 Auburn Drive, One Chagrin Highlands, Suite 200, Beachwood, OH, USA; E-Mail: geriatrics@lidsen.comOBM Geriatrics 2022, volume 6, issue 2 doi:10.21926/obm.geriatr.2202199Received: June 01, 2022Accepted: June 02, 2022Published: June 09, 2022

by Pietro Gareri

Received: 28 February 2022;  Published: 19 May 2022;  doi: 10.21926/obm.geriatr.2202198

The omega-3 long-chain polyunsaturated fatty acids (omega-3 LC-PUFAs) family includes eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA). Although seafood is the richest source of omega-3 LC-PUFAs, because diet alone is often insufficient in older people, they may require food supplements and enriched food as sources of omega-3 LC-PUFAs. It has been reported that long-term intake of 3-5 g/d EPA + DHA as supplements is safe for adults; omega-3 LC-PUFAs exert cardio-metabolic pro [...]

by Mary Gannotti  and Diana Veneri

Received: 07 October 2021;  Published: 16 May 2022;  doi: 10.21926/obm.geriatr.2202197

Chair yoga is a specific form of yoga practiced while seated on a chair, or standing using a chair for support; this adaptation allows those with impaired standing ability to practice safely. The purpose of this scoping review was to analyze the published literature regarding the use of chair/adapted yoga with older adults. Two researchers performed the review. Data sources: PubMed Central, CINAHL, Medline Full Text, Nursing and Allied Health, SPORT discus and TRIP were accessed. Study selection: Inclusion criteria [...]

by Aditi Gupta  , Bor-Jang Hwang  , Daniel Benyamien-Roufaeil  , Sara Jain  , Sophie Liu  , Rex Gonzales  , Robert A. Brown  , Michal Zalzman  and A-Lien Lu

Received: 22 July 2021;  Published: 02 April 2022;  doi: 10.21926/obm.geriatr.2202196

Telomeres consist of special features and proteins to protect the ends of each chromosome from deterioration and fusion. The telomeric DNA repeats are highly susceptible to oxidative damage that can accelerate telomere shortening and affect telomere integrity. Several DNA repair factors including MYH/MUTYH DNA glycosylase, its interacting partners Rad9/Rad1/Hus1 checkpoint clamp, and SIRT6 aging regulator, are associated with the telomeres. MYH prevents C:G to A:T mutation by removing adenine mispaired with a frequ [...]

by Terence Seedsman

Received: 01 August 2021;  Published: 15 March 2022;  doi: 10.21926/obm.geriatr.2201195

While increases in life expectancy along with extended longevity can be seen as a success story, there remains the central issue surrounding the health and quality of life for increasing numbers of older people. As populations live longer the idea that older people should be empowered to remain active and productive citizens will be paramount. Questions concerning the meaningfulness, purpose and desirability of living longer present an existential challenge for all and sundry. It is clear, that the speed of populat [...]

by Lotte Gerholt  , Casper N. Bang  , Eva Gerdts  , Anne Cecilie Larstorp  , Sverre E. Kjeldsen  , Stevo Julius  , Kristian Wachtell  , Peter M. Okin  and Richard B. Devereux

Received: 20 December 2021;  Published: 09 March 2022;  doi: 10.21926/obm.geriatr.2201194

It remains unknown whether left atrial systolic force (LASF), a measure of left atrial function, can be used as a predictor of new-onset atrial fibrillation (NOAF). Furthermore, the effect of the treatment with atenolol and losartan on LASF is unclear. A total of 758 patients without atrial fibrillation at baseline were enrolled from the Losartan Intervention For Endpoint (LIFE) reduction in hypertension echocardiography sub-study. Participants of the LIFE study were randomized to either atenolol-or losartan-based [...]