Table of Content

Open Access Review

Advances in Managing Infections in Lung Transplantation: A Review

Received: 21 November 2023;  Published: 10 May 2024;  doi: 10.21926/obm.transplant.2402215

Abstract

Transplanted lung allografts are particularly susceptible to infection among SOT due to the constant exposure to the environment, aggressive immunosuppressive strategies, and impaired clearance mechanisms after denervation of the transplanted lung. Though prophylactic antimicrobial, antifungal, and antiviral regimens are used as preventive strategies to mitigate the risk of infection, complications related to allograft infection remain one of the primary causes of morbidity and mortality after lung transplantation. [...]

78 519

Open Access Original Research

Frequency of Unplanned Readmissions Following Lung Transplantation During the SAR-COV-2 Pandemic When Hospital Resources Were Strained

Received: 19 October 2023;  Published: 08 May 2024;  doi: 10.21926/obm.transplant.2402214

Abstract

Despite the concerted efforts by lung transplant recipients (LTR) and their medical teams, hospital readmissions are common in the first year following transplantation. Reasons for unplanned readmissions include allograft rejection, infections, and respiratory failure before the SARS-COV-2 pandemic. Clinical predictors of readmissions have changed over time with the higher risk factors of acceptable criteria for recipients and donors. We aimed to assess more recent readmission rates based on group classifications t [...]

160 705

Open Access Original Research

Low Mortality Associated with COVID-19 Infection in Lung Transplant Recipients at a Single Center

Received: 15 October 2023;  Published: 28 April 2024;  doi: 10.21926/obm.transplant.2402213

Abstract

Lung Transplant Recipients (LTR) are particularly vulnerable to severe infection, hospitalization, and death due to community acquired respiratory viruses. As a result, the global SARS-Cov-2 pandemic poses a higher risk to this population. We aim to study the lung function, severity of infection and mortality among LTR at a single center. A retrospective chart review was performed on all LTR at the University of San Diego, California Medical Center between June 2020 and September 2022. Spirometry was performed at 1 [...]

187 890

Open Access Original Research

Contribution of a Single Islet Transplant Program to Basic Researchers in North America, Europe, and Asia through Distributing Human Islets

Received: 23 February 2024;  Published: 23 April 2024;  doi: 10.21926/obm.transplant.2402212

Abstract

There has been a steady expansion in islet isolation and transplantation activity worldwide. In addition to preparing human islets for transplantation, we have been providing human islets to basic researchers. The aim of this study was to review the activity of distribution of human islets to basic researchers in North America, Europe, and Asia, and to investigate if there are any differences in utilization rate of islets among three continents. We reviewed our islet isolation batch files, donor records, and docume [...]

216 1307

Open Access Review

Thrombotic Microangiopathy in Solid Organ Transplantation

Received: 31 January 2024;  Published: 10 April 2024;  doi: 10.21926/obm.transplant.2402211

Abstract

Thrombotic Microangiopathy (TMA) is a syndrome characterized by microangiopathic hemolytic anemia (MAHA) and thrombocytopenia. The presence of schistocytes on peripheral smear, a negative Coombs test, elevated lactate dehydrogenase, increased reticulocyte count and low haptoglobin are often the clues for MAHA. The microvascular process often targets vasculature in kidneys, brain, gastrointestinal system, heart, and skin. A timely diagnosis and treatment are often crucial to prevent severe end organ damage and death [...]

183 1029

Open Access Review

Management of Steatosis in Living Donors: Where Do We Stand?

Received: 23 October 2023;  Published: 01 April 2024;  doi: 10.21926/obm.transplant.2402210

Abstract

With the progressive rise in rates of liver transplantation, stagnant donor pool, and social factors, living donor liver transplantation (LDLT) forms the majority of liver transplantations performed in Asian countries. As the global prevalence of metabolic-associated fatty liver disease (MAFLD) is increasing, around 17-25% of all the prospective donors turn out to be steatotic at the time of evaluation and, as such, rejected for donor hepatectomy, thereby considerably reducing the living donor pool. Steatotic graft [...]

123 770

Open Access Review

Airway Complications after Lung Transplantation

Received: 12 September 2023;  Published: 27 March 2024;  doi: 10.21926/obm.transplant.2401209

Abstract

Lung transplantation in patients with end stage lung disease can improve survival and quality of life. Airway complication incidence varies between 2-33%, but the true incidence is difficult to determine due to a lack of validated classification systems. There are many risk factors for post lung transplant airway complications, the most common being anastomotic ischemia, pulmonary infections, surgical technique and allograph dysfunction. Common complications include formation of granulation tissue, anastomotic sten [...]

127 829

Open Access Communication

Calculated Human Leucocyte Antigens Evolutionary Divergence (cHED)

Received: 15 December 2023;  Published: 11 March 2024;  doi: 10.21926/obm.transplant.2401208

Abstract

Human Leucocyte Antigens (HLA) constitute a highly polymorphic set of genes pivotal to the immune response. The HLA heterozygous advantage hypothesis assumes that heterozygous individuals at the HLA level have a wider range of peptides for T cell recognition than homozygous individuals. Consequently, they possess an enhanced capacity to trigger a targeted immune reaction. The divergent allele advantage hypothesis is an extension of heterozygous advantage, considering the excessive sequence divergence between allele [...]

127 791

Open Access Review

Chronic Lung Allograft Dysfunction, a Review in 2023

Received: 25 May 2023;  Published: 20 February 2024;  doi: 10.21926/obm.transplant.2401207

Abstract

Chronic allograft dysfunction (CLAD) is one of the leading causes of death after lung transplantation [1]. CLAD is a progressive and irreversible decline in lung function after transplant, manifested as an obstructive, restrictive, or mixed ventilatory impairment without any identifiable etiology as infection or acute rejection. Multiple risk factors have been associated with this condition. Despite its significant effect on the mortality of transplanted patients, there is still a lack of powerfully effective thera [...]

171 1164

Open Access Original Research

Evaluation of Total Parenteral Nutrition in the Autologous Transplantation Setting in Patients with AML: A Retrospective Exploratory Analysis

Received: 29 July 2023;  Published: 04 February 2024;  doi: 10.21926/obm.transplant.2401206

Abstract

Malnutrition remains a clinical challenge in AML patients undergoing autologous hematopoietic stem cell transplantation (ASCT), leading to physical deconditioning and prolonged hospitalization. Prospective data are mainly lacking to identify those patients who may particularly benefit from parenteral nutrition in this setting. This observational, non-randomized, retrospective, exploratory cohort study assessed the nutritional development in patients following high-dose chemotherapy (HDCT) with ASCT and explored the [...]

194 1195

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