by Marcus Taylor  , Zakariya Mouyer  , Eltigani Abdelaal  and Nnamdi Nwaejike

Received: 23 July 2024;  Published: 22 January 2025;  doi: 10.21926/obm.transplant.2501232

The axillary intra-aortic balloon pump (ax-IABP) has been proposed as an alternative to the femoral IABP, particularly for patients with comorbidities rendering them unsuitable for fem-IABP insertion. Patient mobilisation with the ax-IABP in situ is deemed an additional potential benefit. We reviewed our experience with the ax-IABP. A single-centre retrospective review of all adult patients undergoing cardiac surgery (including heart transplantation) in a UK quaternary cardiac surgery centre between 2017 and 2021 w [...]

by Ziyad Alharbi

Received: 27 March 2024;  Published: 13 January 2025;  doi: 10.21926/obm.transplant.2501231

The supraclavicular artery flap presents a promising solution for facial reconstruction challenges since 1997, surpassing limitations of traditional methods like the deltopectoral flap. Its extended pedicle and thin, pliable epidermis offer reliable outcomes with minimal donor site morbidity, making it a preferred choice for head and neck reconstruction. This systematic review evaluates the efficacy of pre-expanded supraclavicular artery flaps based on a comprehensive analysis. In accordance with the Preferred Repo [...]

by A. Isabella Shanker  , Lauren T. Maloney  and Julia M. Boster

Received: 23 September 2024;  Published: 10 January 2025;  doi: 10.21926/obm.transplant.2501230

Infection is a leading cause of short-term morbidity and mortality in pediatric patients after liver transplant (LT). Diagnosing infection in this population can be challenging, requiring consideration of laboratory results and clinical context. The prevalence and significance of post-operative leukocytosis has not yet been explored in children after LT. Our goals were to characterize post-transplant leukocytosis in pediatric patients after LT for biliary atresia (BA) and evaluate the relationship between post-LT l [...]

by OBM Transplantation Editorial Office

Received: 02 January 2025;  Published: 02 January 2025;  doi: 10.21926/obm.transplant.2501229

The editors of OBM Transplantation would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2024. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal’s editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up to the Web [...]

by Mouna Daldoul  , Rim Charfi  , Khouloud Ferchichi  , Mouna Ben Sassi  , Syrine Ben Hammamia  , Fatma Medhioub  , Emna Gaies  , Rym Enneifer  , Hanene Eljebari  , Anis Klouz  , Riadh Daghfous  and Sameh Trabelsi

Received: 20 August 2024;  Published: 13 December 2024;  doi: 10.21926/obm.transplant.2404228

Background: Tacrolimus is characterized by a high intra and interindividual pharmacokinetics variability. Data regarding factors that may influence its pharmacokinetics and pharmacodynamics in liver transplantation are limited. The objectives of this study were to assess tacrolimus therapeutic response, pharmacokinetics and adherence in liver transplant recipients. Methods: The study was conducted at the Clinical Pharmacology Department over a period of 12 years from January 2009 to March 2021. We included liver tr [...]

by Michael Y. Shino  , Francisco Javier Ibarrondo  , Jesse L. Clark  , Adreanne Rivera  , Marlene Florian  , Allison Ramsey  , Ariss Derhovanessian  , Rajan Saggar  , Olawale O. Amubieya  , Grant Turner  , Joanna M. Schaenman  , Pryce T. Gaynor  , Omer E. Beaird  , Ashrit Multani  , Reshma M. Biniwale  , Murray H. Kwon  , Christos J. Petropoulos  , Yolanda Lie  , Terri Wrin  , Amparo L. Figueroa  , Brett Leav  , Zelalem Endale  , Kate Anteyi  , Jacqueline M. Miller  , Abbas Ardehali  , David M. Sayah  , David Elashoff  , John A. Belperio  , Otto O. Yang  and S. Sam Weigt

Received: 16 August 2024;  Published: 20 November 2024;  doi: 10.21926/obm.transplant.2404227

Higher-dose mRNA booster vaccines have not been well studied for transplant recipients. This study evaluated the safety, reactogenicity and immunogenicity of higher dose mRNA-1273 booster vaccines among lung transplant recipients (LTRs). This phase 1/2 open-label randomized clinical trial of higher-dose mRNA-1273 booster vaccination enrolled nineteen adult LTRs into the 50 ug (n=8) vs. 100 ug (n=11) groups before enrollment was terminated due to the availability of the bivalent mRNA-1273.222 vaccine. Local and syst [...]

by Sabrine Mekni  , Lamia Torjemane  , Malek Khayati  , Dorra Belloumi  , Rimmel Yosra Kanoun  , Insaf Ben Yaiche  , Rihab Ouerghi  , Ines Turki  , Saloua Ladeb  , Tarek Ben Othman  and Nour Ben Abdeljelil

Received: 29 June 2024;  Published: 11 November 2024;  doi: 10.21926/obm.transplant.2404226

Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) remains the only curative treatment for bone marrow failure (BMF) and hematologic complications of Fanconi anemia (FA). The evolution remains affected by the toxicity, the risk of graft failure, and clonal evolution. This study aimed to identify factors affecting outcomes in FA patients after allo-HSCT. We included FA patients who underwent allo-HSCT between January 2006 and December 2021. The conditioning regimen was cyclophosphamide/fludarabine (Cy/Fl [...]

by Elga J. Vargas  , Julio C. Martinez  and Lina A. Gomez

Received: 26 April 2024;  Published: 03 October 2024;  doi: 10.21926/obm.transplant.2404225

Acne is a chronic inflammatory condition affecting the pilosebaceous units of the skin, characterized by the formation of papules, cysts, comedones, pustules, nodules, and scars. These lesions are typically located on the face and shoulders, although they can extend to the trunk, arms, and legs. In regenerative medicine, biomolecules are fundamental to tissue regeneration. The use of growth factors from autologous platelet-rich plasma emerges as a promising alternative in the treatment of acne and scars. This study [...]

by Yue Qiu  , Yinqian Kang  , Hao Liu  and Ibtesam Hilmi

Received: 12 May 2024;  Published: 30 August 2024;  doi: 10.21926/obm.transplant.2403224

Machine perfusion (MP) techniques, which simulate physiological conditions to allow for the assessment and preservation of organ viability, are currently applied in various solid organ transplantation fields. Owing to the growing demand for liver transplants and the scarcity of available donor livers, MP offers a practical solution for recovering high-risk grafts and increasing the number of potentially usable donor organs. Furthermore, testing and administering novel therapies to allografts may also become advanta [...]

by Elga Johanna Vargas  , Ana Luisa Muñoz  and Lina Andrea Gómez

Received: 21 May 2024;  Published: 13 August 2024;  doi: 10.21926/obm.transplant.2403223

Platelets were the last to be discovered of the three formed blood elements. Several scientists have been interested in them, recognizing them as cells other than leukocytes and erythrocytes. Its job in hemostasis and thrombosis is currently known. Platelets contain growth factors and secrete cytokines, which have roles in inflammation and tissue regeneration processes. This is why platelet concentrates have been widely used in regenerative medicine, an emerging field that involves biomolecules, cells, and scaffold [...]