Airway Complications after Lung Transplantation
Abstract
15 118
Airway Complications after Lung Transplantationby
Syed Nazeer Mahmood
and
Amit Mahajan
Abstract
Lung transplantation in patients with end stage lung disease can improve survival and quality of life. Airway complication incidence varies between 2-33%, but the true incidence is difficult to determine due to a lack of validated classification systems. There are many risk factors for post lung transplant airway complications, the most common being anastomotic ischemia, pulmonary infections, surgical technique and allograph dysfunction. Common complications include formation of granulation tissue, anastomotic sten [...] 15 118 |
Calculated Human Leucocyte Antigens Evolutionary Divergence (cHED)by
Bruno A Lima
Abstract
Human Leucocyte Antigens (HLA) constitute a highly polymorphic set of genes pivotal to the immune response. The HLA heterozygous advantage hypothesis assumes that heterozygous individuals at the HLA level have a wider range of peptides for T cell recognition than homozygous individuals. Consequently, they possess an enhanced capacity to trigger a targeted immune reaction. The divergent allele advantage hypothesis is an extension of heterozygous advantage, considering the excessive sequence divergence between allele [...] 52 384 |
Chronic Lung Allograft Dysfunction, a Review in 2023Abstract
Chronic allograft dysfunction (CLAD) is one of the leading causes of death after lung transplantation [1]. CLAD is a progressive and irreversible decline in lung function after transplant, manifested as an obstructive, restrictive, or mixed ventilatory impairment without any identifiable etiology as infection or acute rejection. Multiple risk factors have been associated with this condition. Despite its significant effect on the mortality of transplanted patients, there is still a lack of powerfully effective thera [...] 80 710 |
Evaluation of Total Parenteral Nutrition in the Autologous Transplantation Setting in Patients with AML: A Retrospective Exploratory Analysisby
Sarah Willi
,
Ulrike Bacher
,
Marie Noelle Kronig
,
Michael Daskalakis
,
Lia Bally
and
Thomas Pabst
Abstract
Malnutrition remains a clinical challenge in AML patients undergoing autologous hematopoietic stem cell transplantation (ASCT), leading to physical deconditioning and prolonged hospitalization. Prospective data are mainly lacking to identify those patients who may particularly benefit from parenteral nutrition in this setting. This observational, non-randomized, retrospective, exploratory cohort study assessed the nutritional development in patients following high-dose chemotherapy (HDCT) with ASCT and explored the [...] 95 700 |
Acknowledgement to Reviewers of OBM Transplantation in 2023Abstract
The editors of OBM Transplantation would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2023. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal’s editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificate of recognition [...] 114 853 |
Immune-Suppression Modulation in Solid Organ Transplant Recipients Admitted for COVID-19by
Francesco Peracchi
,
Giovanna Travi
,
Marco Merli
,
Roberto Rossotti
,
Fulvio Crippa
and
Massimo Puoti
Abstract
SARS-CoV-2 infection has significantly impacted solid organ transplant (SOT) recipients, who are at high risk of disease and worse outcomes. Moreover, therapeutic management in this population is not precise yet. Our study aimed to evaluate the overall survival of SOT recipients and predictive factors for mortality. We also aimed to assess the impact of antiviral treatments and immunosuppressant changes on overall mortality and to evaluate the length of hospital stay of SOT compared to the general population. This [...] 168 1346 |
Lung Donor Selection and Management: An Updated Reviewby
Shefali Mody
,
Soham Nadkarni
,
Shreyash Vats
,
Akshay Kumar
,
Sravanthi Nandavaram
and
Suresh Keshavamurthy
Abstract
The shortage of donor lungs for transplantation is a major challenge, resulting in longer waitlist times for patients with a higher risk of waitlist mortality. It is crucial to continue promoting awareness about organ donation through legislation, public campaigns, and health care provider education. Only a small number of cadaveric donors meet the ideal criteria for lung donation, leaving many lungs unused. Donor lung utilization can be improved by carefully considering the extended-criteria donors, actively parti [...] 265 2118 |
Acute Rejection of the Lung Allograft: Phenotypes and ManagementAbstract
Treatment options for end stage lung diseases are limited to stabilizing lung failure, decreasing disease progression, and symptom management, but significant reversal of lost lung function is often not possible. For well selected patients, lung transplantation may be a viable option to improve both longevity and quality of life. Though outcomes for lung transplant recipients have improved over several decades, long term survival still lags behind that of other solid organ transplant recipients. Longevity after lun [...] 166 1564 |
HLA Typing and Donor-Specific Antibody Screening in Kidney Transplantation: Bridging the Past to the Futureby
Mostafa Mohammed
,
Esmat Al Sharkawy
,
Amel M. Kamal Eldin
,
Emad Allam
,
Manal M. Saber
,
Anthony Nassar
,
Nour Younis
,
Christa Deban
,
Ahmad Jaser
,
Indira Guleria
,
Basset El Essawy
,
Anil Chandraker
,
Mahmoud Nasr
and
Jamil Azzi
Abstract
Human leukocyte antigens (HLA) are unique proteins expressed on the surface of human cells, playing a pivotal role in the immune system, particularly in the contexts of infection, cancer, and transplantation. The widespread adoption of HLA typing methods has become an essential component in assessing donor-recipient compatibility, a crucial limiting factor in solid organ transplantation. In general, the greater the disparity between a donor's and recipient's HLA types, the higher the likelihood of provoking an allo [...] 263 1975 |
Peri-transplant Treatment with Ceftaroline in Kidney Transplant Recipients at Risk of Donor-derived MRSA Infections: A Case Seriesby
Biagio Pinchera
,
Rosa Carrano
,
Emilia Trucillo
,
Alessia D'Agostino
,
Alessia Sardanelli
,
Simona Mercinelli
,
Fabrizio Salemi
,
Amerigo Piccione
,
Elisa Schettino
,
Paolo Romano
,
Gianluca Rompianesi
,
Roberto Ivan Troisi
and
Ivan Gentile
Abstract
The rising prevalence of MDR pathogens has a significant impact on the recipients' outcome, as this increases the risk of graft complications and makes the management of the peri-transplant phase more difficult. Among the different MDR germs, Methicillin-resistant Staphylococcus aureus (MRSA) represents one of the most frequently isolated pathogens. We report for the first time the off-label use of Ceftaroline in six kidney transplant recipients with donor peritransplantation MRSA bacteremia at the Division of Kidn [...] 261 1638 |
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