03 - LIDSEN Publishing Inc.丨The Open Access Publisher

Volume 6,Issue 3

Open Access Original Research

A Clinical Validity-Preserving Machine Learning Approach for Behavioral Assessment of Autism Spectrum Disorder

Abdulmalik A. Lawan and

Nadire Cavus

Received: 31 May 2022; Published: 30 September 2022; doi: 10.21926/obm.neurobiol.2203138

Abstract

Autism spectrum disorder (ASD) is a neuropsychiatric disorder associated with critical challenges related to social, communication, and behavioral issues. Recent studies have proposed machine learning (ML) techniques for rapid and accurate assessment of ASD. However, the mismatch between the ML techniques and the clinical basis of ASD assessment reduces the effectiveness of ML-based assessment tools. The present study proposed an approach that utilized the potential of ML modeling and preserved [...]

Open Access Original Research

Computerized Assessment of Cognitive Development in Neurotypical and Neurodivergent Children

Igor Val Danilov ,

Sandra Mihailova and

Araksia Svajyan

Received: 05 July 2022; Published: 28 September 2022; doi: 10.21926/obm.neurobiol.2203137

Abstract

This study aims to observe the differences in the shared intentionality magnitude in mother-child dyads with neurotypical (NT) children and neurodivergent (ND) children aged 3-6 years. The quality of shared intentionality in infancy is associated with cognitive development. Our results showed that ND children scored six times higher (on average) in quiz-test than NT children. Children with difficulties in interaction (ND children) are more likely to use shared intentionality in conve [...]

Open Access Interview

An Interview with Dr. Francisco J. Barrantes

OBM Neurobiology Editorial Office

Received: 22 September 2022; Published: 26 September 2022; doi: 10.21926/obm.neurobiol.2203136

Open Access Research Article

Neuroprotective (Antioxidant, Antiamyloidogenic, and Antiexcitatory) Effects of Trévo^TM against Cadmium Chloride Neurotoxicity in Adult Male Wistar Rats

Omotayo B. Ilesanmi ,

Rosephine Enadeghe ,

Chinenyenwa U. Aleneme ,

Esther F. Adeogun and

Ufuoma J. Okotie

Received: 29 May 2022; Published: 26 September 2022; doi: 10.21926/obm.neurobiol.2203135

Abstract

Cadmium (Cd) is a heavy metal that is deleterious to brain development as it increases brain aging. Trévo is a multi-herbal supplement that provides various health benefits, including boosting the immune system and detoxification. In this study, we investigated the neuroprotective effects of Trévo against the neurotoxic effects of cadmium chloride (CdCl₂). Thirty male Wistar rats were equally divided into three groups: Group I (normal control), Group II (administered CdCl& [...]

Open Access Original Research

Modeling of Information Processing in Biomorphic Neuroprocessor

Sergey Yu. Udovichenko ,

Alexander D. Pisarev ,

Alexander N. Busygin ,

Abdulla H. Ebrahim ,

Andrey N. Bobylev and

Alexey A. Gubin

Received: 14 June 2022; Published: 22 September 2022; doi: 10.21926/obm.neurobiol.2203134

Abstract

In the present study, we present the results of the modeling of incoming information processing in a neuroprocessor that implements a biomorphic spiking neural network with numerous neurons and trainable synaptic connections between them. Physico-mathematical models of processes of encoding information into biomorphic pulses and their decoding following a neural block into a binary code were developed as well as models of the process of routing the output pulses of neurons by the logic matrix to [...]

Open Access Commentary

Targeting Neuroplasticity for the Management of Pain and Agitation in Alzheimer’s Disease via Bergamot Nanotherapy

Damiana Scuteri ,

Paolo Tonin ,

Maria Tiziana Corasaniti and

Giacinto Bagetta

Received: 05 July 2022; Published: 14 September 2022; doi: 10.21926/obm.neurobiol.2203133

Abstract

Alzheimer’s disease (AD) accounts for 50–70% of cases of dementia worldwide and is a social burden to the affected population. Although several pathogenetic hypotheses have been proposed, evidence favoring the role of aberrant neuroplasticity in the development of the neuropsychiatric symptoms associated with dementia is increasing. Specifically, agitation is resistant to treatment and affects the quality of life, also because of the lack of safe and effective treatment for AD. Alterations in pa [...]

Open Access Original Research

Assessment of Loneliness During the Pandemic: Comparing Various Short Forms of the UCLA Loneliness Scale in South Africa Using Classical Test Theory and Mokken Analysis

Tyrone Pretorius and

Anita Padmanabhanunni

Received: 01 May 2022; Published: 17 August 2022; doi: 10.21926/obm.neurobiol.2203132

Abstract

An important mental health concern arising from the COVID-19 pandemic was the loneliness resulting from the lockdown measures taken by many countries due to the outbreak. Thus, loneliness needs to be studied in detail for intervention purposes. The UCLA Loneliness Scale is the most widely used measure of loneliness. However, the 20-item measure has some drawbacks, including questionnaire fatigue, especially when used with other measures, and a lack of accurate responses to all items. [...]

Open Access Short Communication

Migraine in Adolescents: Comparison of Attack Frequency During School and Vacation Periods

Johannes Drescher ,

Charly Gaul ,

Peter Kropp ,

Yannic Siebenhaar ,

Dirk Reinel and

Jörg Scheidt

Received: 18 May 2022; Published: 16 August 2022; doi: 10.21926/obm.neurobiol.2203131

Abstract

This citizen science project CLUE compared the attack frequency between school and vacation periods among adolescents. The data collection process adopted in citizen science projects opens up the possibility of conducting analyses by including a large number of participants over a long period and across different regions. The data on 684 migraine attacks reported by 68 adolescents aged 16 to 19 years were collected us [...]

Open Access Original Research

Generalized Resistance Resources in the Time of COVID-19: The Role of Sense of Coherence and Resilience in the Relationship between COVID-19 Fear and Loneliness among Schoolteachers

Anita Padmanabhanunni ,

Serena Isaacs ,

Tyrone Pretorius and

Brendon Faroa

Received: 30 April 2022; Published: 15 August 2022; doi: 10.21926/obm.neurobiol.2203130

Abstract

Fear has been the most common emotional response to the COVID-19 pandemic, and excessive fear is associated with various indices of psychological distress, particularly loneliness. Although most people have experienced pandemic-related fear and distress, certain groups who are on the front of service provision have experienced the pandemic in distinct ways, owing to its impact on the nature of their work. Schoolteachers represent one such group; therefore, it is imperative to identif [...]

Open Access Review

Epilepsy in Cerebral Palsy: A Brief Narrative Review

Prabhumallikarjun Patil and

Amanda RB Weber

Received: 18 January 2022; Published: 22 July 2022; doi: 10.21926/obm.neurobiol.2203129

Abstract

Cerebral palsy is defined as “A group of permanent disorders of the development of movement and posture, causing activity limitation, that are attributed to non-progressive disturbances that occurred in the developing fetal or infant brain. The motor disorders of cerebral palsy are often accompanied by disturbances of sensation, perception, cognition, communication, and behavior, by epilepsy, and by secondary musculoskeletal problems [1].” Between 30-40% of people with cerebral palsy also have e [...]

Open Access Case Report

Clival Paraganglioma, Case Report and Literature Review

Rachel Moor ,

Michael Goutnik ,

Brandon Lucke-Wold ,

Dimitri Laurent ,

Si Chen ,

William Friedman ,

Maryam Rahman ,

Nichole Allen ,

Marie Rivera-Zengotita and

Matthew Koch

Received: 30 May 2022; Published: 07 July 2022; doi: 10.21926/obm.neurobiol.2203128

Abstract

Paragangliomas are rare tumors that may present with cranial neuropathies when located along the skull base. Supratentorial paragangliomas are less likely to secrete catecholamines but should be worked up, nonetheless. We highlight a case of a female in her fourth decade found to have a petroclival lesion following initial presentation that included one month of tooth pain, dysphagia, diplopia, hoarseness and right hemifacial hypoesthesia. Magnetic resonance imaging of the brain demonstrated a T [...]

Open Access Original Research

One Week of Continuous Anesthesia by Propofol (2,6-Diisopropylphenol) Does Not Cause Neurobehavioral Changes after Recovery in the Mexican Axolotl Salamander

Sofie Amalie Andersson ,

Mathias Møller Thygesen ,

Anita Dittrich and

Henrik Lauridsen

Received: 07 March 2022; Published: 06 July 2022; doi: 10.21926/obm.neurobiol.2203127

Abstract

The Mexican axolotl salamander is an important model species in regenerative medical research and experiments involving this species often require anesthesia which is usually limited to the duration of the surgical procedure or other interventions, usually lasting no more than a few hours. This study aimed to examine the potential for increasing the duration of anesthesia by continued propofol infusion for a week. Neurobehavioral changes in response to prolonged anesthesia were evaluated after [...]

Open Access Original Research

Psychological Distress due to COVID-19 in the Albanian Adult Population

Vjollca Ndreu ,

Yllka Themeli ,

Ilirjana Zekja and

Fatjona Kamberi

Received: 02 April 2022; Published: 06 July 2022; doi: 10.21926/obm.neurobiol.2203126

Abstract

The World Health Organization declared the COVID-19 pandemic on March 11^th, 2020. The pandemic had significantly affected public health, and the mental health of people was compromised regardless of age or socioeconomic status. In this study, we measured the psychological distress caused by the pandemic and determined the associated factors. An online survey was conducted from November 16^th

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