02 - LIDSEN Publishing Inc.丨The Open Access Publisher

Volume 8,Issue 2

Open Access Original Research

Detection of Activated Pepsin in Bronchoalveolar Lavage and Acute Cellular Rejection in Lung Transplant Recipients

Andrés R. Latorre-Rodríguez ,

Devika Sindu ,

Sumeet K. Mittal and

Ashwini Arjuna

Received: 23 February 2024; Published: 21 June 2024; doi: 10.21926/obm.transplant.2402219

Abstract

Activated pepsin (pepA) in bronchoalveolar lavage (BAL) fluid may be a biomarker of gastric aspiration. We sought to i) evaluate the association of pepA in BAL fluid with acute cellular rejection (ACR) in a cohort of lung transplant recipients (LTRs), ii) assess the association between pepA and isolation of typical gastrointestinal microorganisms from BAL fluid, and iii) explore the accuracy of using pepA concentration as [...]

Open Access Case Report

Management of Calcareous Corneal Degeneration from Medication Washout to Corneal Transplantation. Case Series and Review of the Literature

Filippo Lixi ,

Benedetta Pintus and

Giuseppe Giannaccare

Received: 27 February 2024; Published: 07 June 2024; doi: 10.21926/obm.transplant.2402218

Abstract

Calcareous corneal degeneration is a rare disease characterized by calcium phosphate deposition into the deep corneal layers. Corneal calcification has a multifactorial origin and is associated with various systemic and ocular conditions. Several treatment options showed promising results in the management of this disorder. Herein, two cases of calcareous degeneration occurring postoperatively in patients undergoing surgery for retinal detachment (case #1) and glaucoma (case #2) were reported. D [...]

Open Access Original Research

Circulating lncRNAs HOTTIP and HOTAIR as Potential Biomarkers in Crigler-Najjar Syndrome: A Preliminary Report from Shiraz Liver Transplant Research Center

Nasrin Motazedian ,

Masoud Mokhtari ,

Negar Azarpira ,

Kimia Falamarzi ,

Mohsen Mohammadi ,

Seyed Mohsen Dehghani ,

Sarina Pourjafar ,

Maryam Ataollahi ,

Elaheh Esfandiari ,

Mahdokht Hossein-Aghdaie ,

Seyed Ali Malekhosseini ,

Tayebeh Kazemi and

Mahintaj Dara

Received: 05 May 2024; Published: 04 June 2024; doi: 10.21926/obm.transplant.2402217

Abstract

Crigler-Najjar syndrome (CNS) is a rare autosomal recessive disorder characterized by impaired bilirubin metabolism, leading to neurotoxic unconjugated bilirubin accumulation. Liver transplantation remains the only effective treatment, highlighting the need for novel diagnostic and therapeutic approaches. Long non-coding RNAs (lncRNAs) have emerged as potential biomarkers in various diseases, including cancer. This study aimed to evaluate the expression of lncRNAs HOTTIP and HOTAIR i [...]

Open Access Original Research

Is Donation after Circulatory Determination of Death in Japan Uncontrolled or Controlled?

Tatsuya Kin ,

Hirofumi Noguchi and

Atsushi Kawaguchi

Received: 15 February 2024; Published: 03 June 2024; doi: 10.21926/obm.transplant.2402216

Abstract

Using donation after circulatory determination of death (DCD) donors has been shown to be a potential means of increasing the number of donors for organ transplantation. The purpose of this study was to examine the published practice of DCD in Japan to properly define their practice as controlled or uncontrolled. Through the Web of Science database, we systematically searched articles describing uncontrolled DCD, controlled DCD or Maastricht classification. A total of 12 articles (ten articles r [...]

Open Access Review

Advances in Managing Infections in Lung Transplantation: A Review

Shourjo Chakravorty and

Ashka Patel

Received: 21 November 2023; Published: 10 May 2024; doi: 10.21926/obm.transplant.2402215

Abstract

Transplanted lung allografts are particularly susceptible to infection among SOT due to the constant exposure to the environment, aggressive immunosuppressive strategies, and impaired clearance mechanisms after denervation of the transplanted lung. Though prophylactic antimicrobial, antifungal, and antiviral regimens are used as preventive strategies to mitigate the risk of infection, complications related to allograft infection remain one of the primary causes of morbidity and morta [...]

Open Access Original Research

Frequency of Unplanned Readmissions Following Lung Transplantation During the SAR-COV-2 Pandemic When Hospital Resources Were Strained

Justin Cole ,

Eugene Golts ,

Michael Bernales ,

Dina Shirazi ,

Deepa Kurup ,

Sarah Golts ,

Gordon Yung ,

Aarya Kafi ,

Christine M. Lin ,

Travis Pollema and

Kamyar Afshar

Received: 19 October 2023; Published: 08 May 2024; doi: 10.21926/obm.transplant.2402214

Abstract

Despite the concerted efforts by lung transplant recipients (LTR) and their medical teams, hospital readmissions are common in the first year following transplantation. Reasons for unplanned readmissions include allograft rejection, infections, and respiratory failure before the SARS-COV-2 pandemic. Clinical predictors of readmissions have changed over time with the higher risk factors of acceptable criteria for recipients and donors. We aimed to assess more [...]

Open Access Original Research

Low Mortality Associated with COVID-19 Infection in Lung Transplant Recipients at a Single Center

Rahul Gomez ,

Aarya Kafi ,

Gordon Yung ,

Saima Aslam ,

Christine M. Lin ,

Travis Pollema ,

Eugene Golts and

Kamyar Afshar

Received: 15 October 2023; Published: 28 April 2024; doi: 10.21926/obm.transplant.2402213

Abstract

Lung Transplant Recipients (LTR) are particularly vulnerable to severe infection, hospitalization, and death due to community acquired respiratory viruses. As a result, the global SARS-Cov-2 pandemic poses a higher risk to this population. We aim to study the lung function, severity of infection and mortality among LTR at a single center. A retrospective chart review was performed on all LTR at the University of San Diego, California Medical Center between June 2020 and September 202 [...]

Open Access Original Research

Contribution of a Single Islet Transplant Program to Basic Researchers in North America, Europe, and Asia through Distributing Human Islets

Tatsuya Kin ,

Doug O'Gorman ,

Wendy Zhai ,

Jennifer Moriarty ,

Kyle Park ,

Advaita Ganguly ,

Shawn Rosichuk and

AM James Shapiro

Received: 23 February 2024; Published: 23 April 2024; doi: 10.21926/obm.transplant.2402212

Abstract

There has been a steady expansion in islet isolation and transplantation activity worldwide. In addition to preparing human islets for transplantation, we have been providing human islets to basic researchers. The aim of this study was to review the activity of distribution of human islets to basic researchers in North America, Europe, and Asia, and to investigate if there are any differences in utilization rate of islets among three continents. [...]

Open Access Review

Thrombotic Microangiopathy in Solid Organ Transplantation

Sravanthi Nandavaram ,

Hannah Twist ,

Rickey Evans ,

Sravanthi Paluri ,

Ana Castellanos and

Andres Pelaez

Received: 31 January 2024; Published: 10 April 2024; doi: 10.21926/obm.transplant.2402211

Abstract

Thrombotic Microangiopathy (TMA) is a syndrome characterized by microangiopathic hemolytic anemia (MAHA) and thrombocytopenia. The presence of schistocytes on peripheral smear, a negative Coombs test, elevated lactate dehydrogenase, increased reticulocyte count and low haptoglobin are often the clues for MAHA. The microvascular process often targets vasculature in kidneys, brain, gastrointestinal system, heart, and skin. A timely diagnosis and treatment are often crucial to prevent severe end or [...]

Open Access Review

Management of Steatosis in Living Donors: Where Do We Stand?

Abhideep Chaudhary ,

Anish Gupta ,

Imtiakum Jamir ,

Niteen Kumar and

Gaurav Sood

Received: 23 October 2023; Published: 01 April 2024; doi: 10.21926/obm.transplant.2402210

Abstract

With the progressive rise in rates of liver transplantation, stagnant donor pool, and social factors, living donor liver transplantation (LDLT) forms the majority of liver transplantations performed in Asian countries. As the global prevalence of metabolic-associated fatty liver disease (MAFLD) is increasing, around 17-25% of all the prospective donors turn out to be steatotic at the time of evaluation and, as such, rejected for donor hepatectomy, thereby considerably reducing the living donor p [...]

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