Gene Therapy Strategies for Muscular Dystrophies: Current Insights and Future DirectionsAbstract Gene therapy, a groundbreaking method for addressing genetic mutations, includes strategies such as gene repair, replacement, inactivation, or the introduction of therapeutic genes, circumventing traditional surgical or pharmacological approaches. Delivery through viral or non-viral vectors presents [...] 345 2008 |
Effects of Coenzyme Q10 on H2O2-Induced Oxidative Stress of Human KeratinocytesAbstract Keratinocytes are particularly vulnerable to oxidative stress due to their function as the primary natural protective barrier exposed to chemicals, rays, and pollution to stimulate the formation of free radicals in the body. Two factors of interest correlate with cellular senescence under oxidative [...] 171 1303 |
Comparison of Heavy Metal and Disinfectant Resistance of S. aureus and Enterococcus Isolates with Antibiotic Resistance ProfilesAbstract Antimicrobial resistance is one of the most significant threats to our present and future. Recently, it has been suggested that antibiotic-resistant microorganisms also exhibit resistance to heavy metals and disinfectants, and these resistance profiles may interact with each other. Microorganisms ca [...] 210 1321 |
Acknowledgment to Reviewers of OBM Genetics in 2024Abstract The editors of OBM Genetics would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2024. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer c [...] 110 816 |
Role of Genomics in Neonatal Care and Research—A Narrative ReviewAbstract There is a high prevalence of genetic abnormalities that significantly contribute to overall morbidity and mortality in neonates. Since early diagnosis is crucial for the optimal administration of conventional and customized medications, neonatal acute care has the most significant potential to bene [...] 169 1467 |
A Systematic Review on the Role of SnRK2 Gene in Arabidopsis thaliana Growth Stages under Abiotic StressesAbstract This systematic review examines the role of SnRK2 (Sucrose non-fermenting 1-Related protein Kinase 2) genes in Arabidopsis thaliana growth and responses to abiotic stresses. SnRK2 protein kinases are key components of abscisic acid (ABA) signaling and osmotic stress responses in plants. The review s [...] 321 1855 |
Molecular Markers Used to Reveal Genetic Diversity and Phylogenetic Relationships in Crop Plantsby
Özlem Özbek
Abstract Genetic diversity allows plants to adapt to changing environmental conditions to survive and increases their ability to respond to yield, production, pests and diseases. The application of molecular markers developed due to developments in biochemistry, molecular biology, and plant technology has sh [...] 205 2176 |
Important Guide for Natural Compounds Inclusion in Precision MedicineAbstract Precision medicine describes the definition of disease at a higher resolution by genomic and other technologies to enable more precise targeting of disease subgroups with new therapies. Preventative or therapeutic interventions can be developed with the knowledge of how a compound acts safely in the [...] 187 1253 |
Epstein-Barr Virus and Helicobacter pylori as Two Main Risk Factors in Gastric Cancerby
Parisa Zeynali
,
Hossein Teimouri
,
Seyed Mohammad Ali Hashemi
,
Arefeh Ebrahimian
,
Seyed Nooreddin Faraji
,
Shahriar Sakhaei
and
Emad Behboudi
Abstract Microbial and viral pathogens have emerged as pivotal agents in oncogenesis. Research conducted in the last twenty years has significantly enhanced our comprehension of the cancer-causing capabilities of infectious agents. An illustrative instance is gastric cancer (GC), which is closely associated [...] 309 1417 |
External Validation and Modification of a New Score for Predicting Mortality in Patients with COVID-19 in High Altitude Patients. A Peruvian Studyby
Walter Calderón-Gerstein
,
Gabriela Torres-Samaniego
,
Kevin Pazos-Sovero
and
Mirella Calderón-Anyosa
Abstract This study aims to validate two predictive mortality scores for patients with COVID-19 to support clinical decision-making in those who require hospitalization. The tomographic patterns found can be added to the original scores to increase their predictive power. Retrospective, analytical, observati [...] 168 1150 |