Molecular Cytogenetic Characterization of Rare but Repeatedly Observed TranslocationsAbstract Balanced chromosomal rearrangements, including translocations, contribute to infertility, repeated abortions, and/or genetically imbalanced offspring in corresponding carriers. A translocation is usually considered a unique, de novo, or familial event. Besides, some translocatio [...] 345 2053 |
Reflective Evaluation of Next-Generation Sequencing Data during Early Phase Detection of the Delta Variantby
Upasana Ramphal
,
Derek Tshiabuila
,
Yajna Ramphal
,
Jennifer Giandhari
,
Carel van Heerden
,
Cheryl Baxter
,
Stephanie van Wyk
,
Sureshnee Pillay
,
Oluwakemi Laguda-Akingba
,
Eduan Wilkinson
,
Richard Lessells
and
Tulio de Oliveira
Abstract During the SARS-CoV-2 pandemic, next-generation sequencing (NGS) technologies like the Ion Torrent S5 and Illumina MiSeq, alongside advanced software, improved genomic surveillance in South Africa. This study analysed anonymized samples from the Eastern Cape using Genome Detective and NextClade, sho [...] 503 2870 |
Biotechnology Innovation in Do-It-Yourself (DIY) Gene Editing: A Call for a New Regulatory FrameworkAbstract The expansion of do-it-yourself (DIY) gene editing, facilitated by Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology, has catalyzed a significant shift in scientific research and biotechnology innovation. This movement is propelled by a community-driven approach that chal [...] 555 4128 |
Bacteriophages Therapy: Exploring Their Promising Role in Microbiome Modulation and Combatting Antibiotic ResistanceAbstract Bacteriophages, or phages, are viruses that infect bacteria, exhibiting specificity towards particular bacterial strains. Despite being overshadowed by traditional antibiotics in the West, interest in phage therapy has resurged due to the escalating antimicrobial resistance crisis. Understanding pha [...] 470 3052 |
The Significance of Key Proteins in the RAS Signaling Pathway: Implications for Cancer and Therapeutic Targetsby
Emad Fadhal
Abstract The RAS signaling pathway is a crucial cell transduction pathway central to transmitting signals from outside the cell to the cell nucleus and influencing fundamental biological mechanisms like cell growth, division, and specialization. This signaling pathway has recently received much attention in [...] 413 2318 |
Cryptic Resilience: Decoding Molecular Networks in Pearl Millet for Enhanced Heat Stressby
Faten Dhawi
Abstract Pearl millet (Pennisetum glaucum), a vital cereal crop renowned for its drought tolerance, is a cornerstone for smallholder farmers in arid and semi-arid regions, ranking as the fifth most significant cereal globally. Despite its resilience, the molecular mechanisms underlying i [...] 588 3191 |
Prevention of Drug Resistant Epilepsy and Developmental Epileptic Encephalopathy: Preventative Vigabatrin Treatment in Tuberous Sclerosis Complex and the Case for Fenfluramine Treatment of Children with Newly Diagnosed Dravet Syndromeby
Amanda Pong
and
Pavel Klein
Abstract Tuberous sclerosis complex (TSC) is caused by mutations of hamartin (TSC1) or tuberin (TSC2) resulting in disinhibition of the mTOR pathway of cellular proliferation and differentiation and severe neurocognitive impairment, intractable epilepsy and tumors. Epilepsy develops in ~90% folll [...] 428 2740 |
Induced Mutagenesis using Gamma Rays: Biological Features and Applications in Crop ImprovementAbstract Induced mutagenesis has emerged as an essential field of plant breeding to address global food security challenges, offering tools to enhance crop productivity, resistance, and nutritional value. Among the mutation induction tools, the physical mutagen such as gamma rays holds promise for efficient [...] 876 8356 |
Salinity Stress in Maize: Consequences, Tolerance Mechanisms, and Management Strategiesby
Mohammad Sohidul Islam
,
Md.Rafiqul Islam
,
Md.Kamrul Hasan
,
ASM Golam Hafeez
,
Md Kaium Chowdhury
,
Moaz Hosen Pramanik
,
Muhammad Aamir Iqbal
,
Murat Erman
,
Celaleddin Barutcular
,
Ömer Konuşkan
,
Anamika Dubey
,
Ashwani Kumar
and
Ayman El Sabagh
Abstract Maize, along with rice and wheat, is a popular staple food crop worldwide, and the most widely produced cereal crop. It is a versatile crop that may be utilized as a source of raw materials for human and animal fodders. Low agricultural yield and rapid population expansion significantly threaten fut [...] 684 6087 |
Unveiling Genetic Variation in Garlic Genotypes in Response to Rust Disease Using RAPD Markersby
Somayeh Alimoradi Askari
,
Mehdi Nasr Esfahani
,
Kowsar Shirazi
,
Arman Nasr Esfahani
,
Hossein Zeinalzadeh-Tabrizi
and
Mojtaba Mohammadi
Abstract Garlic (Allium sativum), cultivated worldwide for its medicinal and nutritional value, faces challenges due to diseases caused by various pathogens. In this study, eleven garlic genotypes from Iran and one from China [...] 521 2999 |