Cytohistopathological Correlation of 884 Cervical Pap Smears as Bethesda System 2014: A Hospital-Based StudyAbstract Cervical carcinoma is most common in Indian women of which Rural women are predominantly affected. The most common etiological factor is human papillomavirus (HPV ). The present study aims to assess the diagnostic accuracy, sensitivity, specificity, and different patterns of cervical Pap smears by c [...] 33 229 |
Abiotic Stress: Interplay Between ROS Production and Antioxidant Machinery, Signaling, and ROS HomeostasisAbstract Climate change poses a substantial threat to global crop yield. Moreover, crop production is likely to reduce in the near future because of increasing average temperatures, widespread extreme climate events, and the loss of agricultural land. Abiotic stresses are the major factors limiting the growt [...] 90 449 |
Novel Insights into Epigenetic Control of Autophagy in CancerAbstract The autophagy mechanism recycles the damaged and long-standing macromolecular substrates and thus maintains cellular homeostatic and proteostatic conditions. Autophagy can be an unavoidable target in cancer therapy because its deregulation leads to cancer formation and progression. Cancer can be con [...] 86 515 |
Comparison of Sputum and Oropharyngeal Microbiome Compositions in Patients with Non-Small Cell Lung Cancerby
Elizaveta Baranova
,
Vladimir Druzhinin
,
Ludmila Matskova
,
Pavel Demenkov
,
Valentin Volobaev
and
Alexey Larionov
Abstract Recent findings indicate that the microbiota is involved in the development of lung cancer by inducing inflammatory responses and generating genome damage. This study aimed to compare sputum microbiomes from the mouth and oropharynx in non-small cell lung carcinoma (NSCLC) patients. A second goal wa [...] 51 386 |
Live-Born Double Aneuploidy at the Johns Hopkins Cytogenomics Laboratory: Case Report and Review of the Literatureby
Jaclyn Murry
and
Ying Zou
Abstract Double aneuploidy is the co-occurrence of aneuploidy of two different chromosomes within the same individual. Genomic imbalance associated with two aneuploidies in humans is associated with early lethality, and observation in live-born humans is rare. In isolation, trisomy of chromosomes 13, 18, 21, [...] 55 454 |
“Not Private at All:” Comparative Perspectives on Privacy of Genomic Data, Family History Data, Health-Related Data, and Other Personal Databy
Nora B. Henrikson
,
Paula R. Blasi
,
Marlaine Figueroa Gray
,
Lorella Palazzo
,
Aaron Scrol
and
Stephanie M. Fullerton
Abstract People choose how and if to generate and disclose not just personal genomic data, but also multiple other types of personal health and non-health related data. To contextualize choices about genetic testing and genetic data disclosure, we explored perspectives of genomic data privacy and disclosure [...] 95 623 |
Cytoplasmic Microinjection of piggyBac Transposase mRNA and Transposon Vectors for Efficient In Vitro Production of Transgenic Porcine Parthenotesby
Rico Miyagasako
,
Jin Hansol
,
Satoshi Watanabe
,
Kazuchika Miyoshi
,
Emi Inada
and
Masahiro Sato
Abstract The efficient production of transgenic (Tg) piglets has remained a challenge in the field of domestic animal studies. Unlike mice, the pronuclei of pig zygotes cannot be easily studied because of the abundance of lipid droplets. Therefore, the zygotes must be briefly centrifuged before pronuclear in [...] 124 1132 |
Newborn Screening in Gaucher Disease: A Bright and Complicated FutureAbstract Gaucher disease (GD) is one of the most common lysosomal storage disorders resulting from biallelic mutations in the GBA1 gene, causing a dysfunction of the lysosomal hydrolase, glucocerebrosidase (acid-β-glucosidase; E.C 3.2.1.45). Clinical manifestations are heterogenous and c [...] 145 1004 |
Successive Detection of Telomerase by IHC and Assessment of Telomere Length by Q-FISH in Paucicellular Cumulus Samples from Cumulus-Oocyte Complexes Obtained in Assisted Reproduction Programsby
Anna Pendina
,
Mikhail Krapivin
,
Irina Mekina
,
Irina Aleksandrova
,
Yanina Sagurova
,
Evgeniia Komarova
,
Mariia Ishchuk
,
Andrei Tikhonov
,
Olesya Bespalova
,
Alexander Gzgzyan
,
Igor Kogan
and
Olga Efimova
Abstract This paper suggests an approach for the use of a single paucicellular histological sample to investigate two characteristics indicative of the cell’s functional potential: 1) the content of telomerase reverse transcriptase (TERT) and 2) the telomere length. An algorithm has been suggeste [...] 106 974 |
High-Altitude Pulmonary Edema in the Context of COVID-19Abstract High-altitude pulmonary edema (HAPE) and COVID-19 pneumonia are different diseases, but HAPE-susceptible individuals (whose susceptibility often has a genetic basis) can also suffer from severe COVID-19. We hypothesized that certain pathogenic mechanisms might overlap if such a coinciden [...] 103 1212 |
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