X Ray-Induced Insulinoma Cell Line Rin-5F Has a Novel Mutation Site, C.A1459G (P.T487A), in Death Domain Associated Protein (DAXX) Gene
Abstract
46 327
X Ray-Induced Insulinoma Cell Line Rin-5F Has a Novel Mutation Site, C.A1459G (P.T487A), in Death Domain Associated Protein (DAXX) GeneAbstract A popular toxicological and pharmacological research cell line is the insulin-secreting pancreatic cell line Rin-5F. The cell line originates from insulinomas induced by X-ray exposure. The author of this report looked at the mutation status of the DAXX gene in the Rin-5F cell line clone.& [...] 46 327 |
Preimplantation Genetic Testing: Personal Views Regarding the Invasiveness of Trophectoderm Biopsy and Risks on Embryos Development “An Operators Survey”Abstract This study aims to assess the Trophectoderm (TE) biopsy practice in Jordan in terms of the following effectiveness parameters: timing of zona breaching, risk of inner cell mass herniation if zona breaching was done on day 3, timing of TE sampling, method of biopsy (pulling or flicking), [...] 93 758 |
A Review on Male Infertility and Herbal Medicine: Complementary and Alternative Therapies in Animal ModelsAbstract Various factors contributing to male infertility include genetic determinants, hormonal/neurological imbalance, erectile/libido disorders, genital tract injuries, and toxic/ischemic testicular injuries. Herbs increase sperm count and quality parameters, as well as sexual performance in infertile men [...] 74 560 |
Mosaic Potocki-Lupski Syndrome Due to a Supernumerary Marker Chromosome Containing RAI1Abstract Potocki-Lupski syndrome (PTLS) is a recurrent microduplication syndrome characterized by developmental delay, behavioral abnormalities, mildly dysmorphic facial features, hypotonia, and sleep disorders. We report here a 3-year-old girl diagnosed with mosaic PTLS harborin [...] 86 535 |
Challenges and Opportunities of Gene Therapy in Cancerby
Milky Mittal
,
Annu Kumari
,
Bhashkar Paul
,
Adya Varshney
,
Bhavya .
,
Ashok Saini
,
Chaitenya Verma
and
Indra Mani
Abstract Gene therapy involves either the direct introduction of genetic material (DNA or RNA) into the host cell (or organ), known as in vivo gene therapy, the re-introduction of the modified target cells taken out of the host, or ex vivo gene therapy. Cancer is mai [...] 196 948 |
The Jacobs Syndrome: Clinical Caseby
Elena A. Tkachuk
and
Galina Kurenkova
Abstract This work describes a clinical case of a violation of sex formation in a newborn child with Y-chromosome dysomy. The diagnostic challenges related to Y-chromosome variability and associated anomalies in sex development are being considered. The work presents clinical and laboratory data [...] 65 527 |
Exploring Education for Children with 22q11.2 Deletion Syndrome: A Qualitative Study of Mothers PerspectivesAbstract 22q11.2 deletion syndrome (22q11.2DS) is a complex and widely variable genetic syndrome involving multisystem physical health problems, significant cognitive and psychosocial challenges, all of which may impact upon learning and academic achievement. In the current study, we explored mothers’ percep [...] 107 1233 |
Molecular Study on Y Chromosome Microdeletion in Male Infertility: A Cross-Sectional Design in Indonesian Menby
Dicky Moch Rizal
,
Ika Setyawati
,
Arya Adiningrat
,
Agus Widiyatmoko
,
Supriyatiningsih
and
Nandia Septiyorini
Abstract Y chromosome microdeletions (YCMs) are one kind of genetic disorder that contributes to male infertility. This study aims to determine the profile of YCMs in the infertile male population in Indonesia. This cross-sectional study was conducted by identifying YCMs testing data on 49 infertile male pat [...] 87 560 |
MiRNAs as Promising Therapeutic Targets for Breast Cancerby
Morkoss M. Fakhry
,
Asmaa R. Abdel-Hamed
,
Noha M. Mesbah
,
Dina M. Abo-Elmatty
,
Mohamed M. Sayed-Ahmed
,
Abdel-Moneim M. Osman
and
Ola S. Ahmed
Abstract Breast cancer (BC) is the most common cause of cancer-related death and is the malignancy most frequently diagnosed in females worldwide. BC incidence is predicted to continue increasing worldwide. Without interventions, annual new cases will reach over 3 million by 2030. Genetic abnormalities accou [...] 96 615 |
B5N10 Nanocarrier Functionalized with Al, C, Si Atoms: A Drug Delivery Method for Infectious Disease Remedyby
Fatemeh Mollaamin
and
Majid Monajjemi
Abstract As proof has recommended a close connection between COVID-19 and neurodegenerative disorders, this article aims to investigate the chloroquine (CLQ) drug as the SARS-CoV-2’s primary protease, which can prevent in vitro viral duplication of all diverse experiments to present. CLQ is an anti-viral dru [...] 100 665 |
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