A Neurodevelopmental Perspective for Autism-Associated Gene Function
Abstract
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A Neurodevelopmental Perspective for Autism-Associated Gene FunctionAbstract
Large-scale genetic sequencing studies have identified a wealth of genes in which mutations are associated with autism spectrum disorder (ASD). Understanding the biological function of these genes will shed light onto the neurodevelopmental basis of ASD. Here, we defined functional categories representing brain development -- (1) Cell Division and Survival, (2) Cell Migration and Differentiation, (3) Neuronal Morphological Elaboration, (4) Development and Regulation of Cellular Excitability, and (5) Synapse Forma [...] 1130 7475 |
Neurobiology of Sleep and Microbiomics in Agingby
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(1) Background: The daily rhythms of life on earth are governed by a central clock located in the hypothalamus and entrained primarily by light. By virtue of its connections to a myriad of other clocks located both in the brain and in peripheral organs and cells, this clock provides a timing signal based on the light/dark cycle by which organismal physiology and behaviour are governed. Disturbances of these natural rhythms have multiple downstream effects, frequently resulting in dysregulations of sleep and wake cy [...] 938 9627 |
FASD and Brain Development: Perspectives on Where We are and Where We Need to Goby
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Maternal consumption of alcohol (ethanol) during pregnancy can lead to life-long neurobehavioral and cognitive abnormalities in the offspring, collectively referred to as Fetal Alcohol Spectrum Disorders (FASD). Prenatal exposure to ethanol is one of the leading causes of non-genetic intellectual disability and FASD is an umbrella category that includes Fetal Alcohol Syndrome, Partial Fetal Alcohol Syndrome, Alcohol Related Birth Defects, and Alcohol Related Neurodevelopmental Disorder. Children with a history of i [...] 1083 8433 |
Perspectives on the Neurobiology of Antipsychotic Drugs in Psychiatric DisordersAbstract
Antipsychotics have been a pillar in the treatment of schizophrenia since their introduction more than 60 years ago. Their variety in structures and receptor binding properties confers on them a complex clinical profile of effectiveness and risk of adverse side-effects. Although antipsychotics are best known for their therapeutic effects in schizophrenia, these are limited to the positive symptoms, with much less influence on negative symptoms or cognitive deficits. Moreover, although the newer (so-called second-ge [...] 901 7894 |
Experimental Study and Kinetic Modeling of Agro-Industrial Wastes for Conversion to Fuel Gas via the Boudouard ReactionAbstract
Independent parallel reactions (IPR) and distributed activation energy (DAEM) kinetic models were developed and compared for the combined pyrolysis-gasification of two agro-industrial waste materials. The aim was to recycle greenhouse gas carbon dioxide for mitigating emissions, to evaluate the thermal behavior, reactivity, conversion and product composition in terms of structural/chemical characteristics of the fuels, and to provide accurate kinetic parameters useful in the scaling-up of the process. The experimen [...] 77 405 |
Optimization of Heat Transfer in Parabolic Trough Collectors Using Advanced Turbulator Designs and Nanofluidsby
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Parabolic trough collectors (PTCs) are essential for solar thermal energy systems, and their thermal efficiency can be significantly enhanced using turbulators and nanofluids. This numerical study introduces three novel fin-spiral turbulator configurations (4, 7, and 10 blades) to enhance heat transfer within the absorber tube. Additionally, three nanofluid types including water-based single-walled carbon nanotubes (SWCNT), cupric oxide (CuO), and a hybrid SWCNT-CuO, at concentrations of 1%, 3%, and 5% were evaluat [...] 127 698 |
Acknowledgment to Reviewers of Journal of Energy and Power Technology in 2024Abstract
The editors of Journal of Energy and Power Technology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2024. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers can download a certificate of recognition directly from our submission system. Additionally, reviewers can [...] 57 428 |
Quantification and Comparative Analysis of Environmental Factors to Large-Scale Solar Plant’s Energy Performance via Regression and Linear Correlation Modelsby
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Performance degradation, including system deterioration, corrosion, and energy loss in solar PV systems, can be caused by environmental conditions such as high humidity, frequent rainfall, and temperature swings in tropical nations. Over the years, photovoltaic energy has been successfully developed to have low production costs and high efficiency. It has been the main reason that solar energy is one of the fastest-growing renewable energies in the world, with a generation of 821 TWh of electricity since 2021, repr [...] 109 699 |
High Data Rate MWD Mud Pulse Telemetry – From Mysteries to DiscoveryAbstract
Our new approach to MWD mud pulse telemetry offers significant increases over conventional data rates. Using waveguide acoustics, we show that common drilling communications channels support carrier frequencies exceeding several hundred Hertz. Such signals are prone to attenuation over large drillpipe distances. Low power, self-spinning “turbosirens” are designed, providing high torque and rotation rate performance at all flow rates without electric or hydraulic motor drives. The sirens rotate, drawing only on [...] 195 1137 |
Post-Combustion CO2 Capture from an Industrial Power Plant Using Five Chemical Solvents: A Comparative TEAAbstract
CO2 capture processes using five chemical solvents were modeled in Aspen Plus V.12.1 for the capture of more than 90% CO2 from a 456 ton/hour split flue gas stream containing 12.02 mol% CO2 emitted by the Longview 780 MW power plant (West Virginia, USA). Since the flue gas contained 33.10 ppmv SO2 and 35.47 ppmv NO2, a gas polishing process, using deionized water (DIW), was included in the model for complete scrubbing of SO2 and NO2 from the raw flue gas before the CO2 capture process. The five chemicals used for C [...] 270 1092 |
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