Membranome Similarity between Glioblastoma Multiforme Cell Lines and Primary Tumors
Abstract
(ISSN 2573-4407)
OBM Neurobiology is an international peer-reviewed Open Access journal published quarterly online by LIDSEN Publishing Inc. By design, the scope of OBM Neurobiology is broad, so as to reflect the multidisciplinary nature of the field of Neurobiology that interfaces biology with the fundamental and clinical neurosciences. As such, OBM Neurobiology embraces rigorous multidisciplinary investigations into the form and function of neurons and glia that make up the nervous system, either individually or in ensemble, in health or disease. OBM Neurobiology welcomes original contributions that employ a combination of molecular, cellular, systems and behavioral approaches to report novel neuroanatomical, neuropharmacological, neurophysiological and neurobehavioral findings related to the following aspects of the nervous system: Signal Transduction and Neurotransmission; Neural Circuits and Systems Neurobiology; Nervous System Development and Aging; Neurobiology of Nervous System Diseases (e.g., Developmental Brain Disorders; Neurodegenerative Disorders).
OBM Neurobiology publishes research articles, technical reports and invited topical reviews. Although the OBM Neurobiology Editorial Board encourages authors to be succinct, there is no restriction on the length of the papers. Authors should present their results in as much detail as possible, as reviewers are encouraged to emphasize scientific rigor and reproducibility.
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Rapid publication: manuscripts are undertaken in 11.8 days from acceptance to publication (median values for papers published in this journal in the second half of 2021, 1-2 days of FREE language polishing time is also included in this period).
Membranome Similarity between Glioblastoma Multiforme Cell Lines and Primary TumorsAbstract Genes encoding for proteins associated with the plasma membrane, referred to as the membranome, have long been recognized to play an important role in the development and maintenance of glioblastoma multiforme (GBM). GBM cell lines are commonly used to mimic tumors for in vitro experiments, but the extent to which they resemble GBM tumors in relation [...] |
Intrinsic Lexical Intentionality and the Mathematics of HomomorphismAbstract Moisl [1, 2] proposed a model of how the brain implements intrinsic intentionality with respect to lexical and sentence meaning, where 'intrinsic' is understood as 'independent of interpretation by observers external to the cognitive agent'. The discussion in both was mainly philosophical and qualitative; the present paper gives a mathematical account [...] |
Who Believes in Fake News: A Study on the Relationship between Affective Temperament, Cyberchondria and Problematic Use of the Internet during the COVID-19 Pandemicby
![]() ![]() ![]() ![]() ![]() ![]() Abstract The COVID-19 outbreak has been associated with various psychological problems, such as Cyberchondria, constant research for information online, to obtain health-related information. This was associated with problematic social media use and various psychological problems. This study aimed to measure the characteristics of fear and anxiety of COVID-19 [...] |
Subjective Assessments of the Pandemic Situation and Academic Adaptation of University StudentsAbstract Students’ academic adaptation during the pandemic is the key problem for the educational system. Even though certain success has been achieved in the organization of education with distance learning technologies and additional learning tools, there are still plenty of other difficulties that affect students’ adaptation. The purpose of the study [...] |
Acknowledgment to Reviewers of OBM Neurobiology in 2022Abstract The editors of OBM Neurobiology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2022. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication [...] |
How Pathologists Dealt with the First Wave of the COVID-19 Pandemic: A Qualitative Studyby
![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Abstract During the first wave of the COVID-19 pandemic, pathologists had to follow new protocols in their work environment around the world to limit or prevent the possibility of transmission of the infection during the autopsy of infected corpses. By using a qualitative research design, in this study, we investigated the emotions, experiences, and opinions [...] |
Anti-Violence Centers in Italy During the COVID-19 Emergency: Support Strategies for Women Victims of Violenceby
![]() ![]() ![]() ![]() ![]() ![]() Abstract The COVID-19 pandemic has negatively impacted anti-violence centers for women. This study aims to investigate how the COVID-19 pandemic restrictions affect: the assistance and protection functions of the anti-violence centers; the needs of women victims of violence; and the well-being of the professionals working with these women. Twenty-four Italian [...] |
Trauma-Focused Cognitive Behavioral Therapy (TF-CBT), Cognitive Behavioral Intervention on Trauma in Schools (CBITS), and Other Promising Practices in the Treatment of Post-Traumatic Stress Disorder in Children and Adolescents: Evidence EvaluationAbstract PTSD is a serious mental health condition with a lifetime prevalence of 1% to 14% in the general population. Several studies have evaluated evidence-based treatment approaches for children and adolescents. Interventions focusing on trauma are considered first-line treatments. Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) and a similar type of [...] |
Transcranial Electrical Stimulation in Migraine – How Does It Work and What Can We Learn from It?by
![]() ![]() Abstract Although being one of the most common neurological disorders, migraine is commonly misunderstood and misdiagnosed. Current treatments rely on pharmacological approaches, which have been shown not to be effective for all, and so alternative, non-invasive treatments are being sought. Transcranial stimulation could be a possible treatment for migraine [...] |
Neuroprotective Potentials of Honey for Cerebral Small Vessel Diseaseby
![]() ![]() ![]() ![]() ![]() ![]() ![]() Abstract The nectar produced by bees in nature is known as honey and has been consumed for its nutritional and medicinal properties. There is growing evidence that honey and its compounds have anti-inflammatory, antioxidant and anti-microbial properties that are relevant to the maintenance of health and the prevention of illnesses, including cardiocerebrovascula [...] |
Dynamic Resting-State Functional Connectivity in Migraineursby
![]() Abstract Functional magnetic resonance imaging (fMRI) is widely used to detect changes in the resting-state brain networks of migraine patients. Functional connectivity fMRI analysis examines the functional organization of the brain based on temporal correlations of blood oxygen level-dependent signal changes in different brain regions. Most previous resting [...] |
An Empirical Study on the Communication and Usage Psychology of Emoji in WechatAbstract As an indispensable active atmosphere and meaningful emotional expression in social media, emojis describe the emotions of users in specific situations in a funny, humorous, euphemistic, and implicit form and attract users to use them consciously or unconsciously with their quick and convenient features. Currently, the research on the psychology of [...] |
Challenges and Problems on Self-directed Learning Readiness in Non–face-to-face Educational Settings During COVID-19by
![]() ![]() Abstract This study aimed to verify whether self-directed learning readiness (SDLR) level can be significantly predicted by the literacy of learning management system (LLMS), motivation, and feedback interaction (FI) in non–face-to-face educational settings. We performed Pearson’s correlation analysis and multiple regression analysis. A total of 206 online [...] |
Possible Preventive Effect of Ziziphora clinopodioides Lam. Essential Oil on Some Neurodegenerative Disordersby
![]() ![]() Abstract The present article describes some characteristics of the effect of essential oil (EO) extracted from Ziziphora clinopodioides harvested from Armenian highlands on microglial cell lines (BV-2 wild-type (WT) and acyl-CoA oxidase1 (ACOX1)-deficient (Acox1–/–) cells). The mutant cell line was used as a model to investigate cellular oxidative damage [...] |
Human Attention Assessment Using A Machine Learning Approach with GAN-based Data Augmentation Technique Trained Using a Custom Datasetby
![]() ![]() ![]() ![]() ![]() ![]() Abstract Human–robot interactions require the ability of the system to determine if the user is paying attention. However, to train such systems, massive amounts of data are required. In this study, we addressed the issue of data scarcity by constructing a large dataset (containing ~120,000 photographs) for the attention detection task. Then, by using this [...] |
A Clinical Validity-Preserving Machine Learning Approach for Behavioral Assessment of Autism Spectrum Disorderby
![]() ![]() Abstract Autism spectrum disorder (ASD) is a neuropsychiatric disorder associated with critical challenges related to social, communication, and behavioral issues. Recent studies have proposed machine learning (ML) techniques for rapid and accurate assessment of ASD. However, the mismatch between the ML techniques and the clinical basis of ASD assessment reduces [...] |
Computerized Assessment of Cognitive Development in Neurotypical and Neurodivergent ChildrenAbstract This study aims to observe the differences in the shared intentionality magnitude in mother-child dyads with neurotypical (NT) children and neurodivergent (ND) children aged 3-6 years. The quality of shared intentionality in infancy is associated with cognitive development. Our results showed that ND children scored six times higher (on average) in [...] |
Neuroprotective (Antioxidant, Antiamyloidogenic, and Antiexcitatory) Effects of TrévoTM against Cadmium Chloride Neurotoxicity in Adult Male Wistar RatsAbstract Cadmium (Cd) is a heavy metal that is deleterious to brain development as it increases brain aging. Trévo is a multi-herbal supplement that provides various health benefits, including boosting the immune system and detoxification. In this study, we investigated the neuroprotective effects of Trévo against the neurotoxic effects of cadmium chloride [...] |
Modeling of Information Processing in Biomorphic Neuroprocessorby
![]() ![]() ![]() ![]() ![]() ![]() Abstract In the present study, we present the results of the modeling of incoming information processing in a neuroprocessor that implements a biomorphic spiking neural network with numerous neurons and trainable synaptic connections between them. Physico-mathematical models of processes of encoding information into biomorphic pulses and their decoding following [...] |
Targeting Neuroplasticity for the Management of Pain and Agitation in Alzheimer’s Disease via Bergamot NanotherapyAbstract Alzheimer’s disease (AD) accounts for 50–70% of cases of dementia worldwide and is a social burden to the affected population. Although several pathogenetic hypotheses have been proposed, evidence favoring the role of aberrant neuroplasticity in the development of the neuropsychiatric symptoms associated with dementia is increasing. Specificall [...] |
Assessment of Loneliness During the Pandemic: Comparing Various Short Forms of the UCLA Loneliness Scale in South Africa Using Classical Test Theory and Mokken AnalysisAbstract An important mental health concern arising from the COVID-19 pandemic was the loneliness resulting from the lockdown measures taken by many countries due to the outbreak. Thus, loneliness needs to be studied in detail for intervention purposes. The UCLA Loneliness Scale is the most widely used measure of loneliness. However, the 20-item measure has [...] |
Open Access Short Communication Migraine in Adolescents: Comparison of Attack Frequency During School and Vacation PeriodsAbstract This citizen science project CLUE compared the attack frequency between school and vacation periods among adolescents. The data collection process adopted in citizen science projects opens up the possibility of conducting analyses by including a large number of participants over a long period and across different regions. The data on 684 migraine attack [...] |
Generalized Resistance Resources in the Time of COVID-19: The Role of Sense of Coherence and Resilience in the Relationship between COVID-19 Fear and Loneliness among SchoolteachersAbstract Fear has been the most common emotional response to the COVID-19 pandemic, and excessive fear is associated with various indices of psychological distress, particularly loneliness. Although most people have experienced pandemic-related fear and distress, certain groups who are on the front of service provision have experienced the pandemic in distinct [...] |
Epilepsy in Cerebral Palsy: A Brief Narrative Reviewby
![]() ![]() Abstract Cerebral palsy is defined as “A group of permanent disorders of the development of movement and posture, causing activity limitation, that are attributed to non-progressive disturbances that occurred in the developing fetal or infant brain. The motor disorders of cerebral palsy are often accompanied by disturbances of sensation, perception, cognition [...] |
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OBM Neurobiology welcomes the following types of articles: original research, review, communication, opinion, case report, comment, conference report, technical note, book review, etc. There is no restriction on the length of the papers, color figures, supplementary file types. More details please see Instructions for Authors.
Communication
by Daniel Z. Lieberman et al.
OBM Neurobiology 2023
Published: 28 June 2019
Review
by Ekta Kumari et al.
OBM Neurobiology 2023
Published: 13 May 2019
Review
by Paul Loprinzi
OBM Neurobiology 2023
Published: 10 May 2019
Review
by Gina Sizemore et al.
OBM Neurobiology 2023
Published: 31 May 2018
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