Table of Contents
Volume 2,Issue 3
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Ectopic Pelvic Kidney with Anomalous Vascular Supply during Deceased Organ Procurement – Case ReportAbstract Even though renal ectopia is common, there have been very few reports of these kidneys being used for transplantation. The concerns with using such kidneys are subnormal function, ureteral anomalies and complications and anomalous arterial supply which makes arterial reconstruction challenging. Majority of reports are for use in living donor transplantation where good preoperative imaging is available. There is very scant literature reporting use of ectopic pelvic kidneys from deceased donors. W [...] |
Role of Automated Insulin Delivery (Artificial Pancreas) in Islet Transplantation: An In Silico AssessmentAbstract Human pancreatic islet transplantation is a minimally-invasive procedure that is gaining recognition for the treatment of type 1 diabetes (T1D). Selected patients with unstable T1D, hypoglycemia unawareness, history of severe hypoglycemia, and glycemic lability, not successfully stabilized with intensive insulin treatment, can be offered this alternative therapy that has been shown to provide long-term glycemic control with near-normalization of hemoglobin A1c in the absence of severe hypoglycem [...] |
The Holy Grail to Clinical Transplant Tolerance Is Paved with HLA EpitopesAbstract The Holy Grail to Clinical Transplant Tolerance is Paved with HLA Epitopes |
Acceptance of HPV Vaccination in Kidney Transplant Recipientsby
Sean A. Hebert
,
Aleksandra M. DeGolovine
,
Karen J. Vigil
,
Sonal Bhatnagar
,
Cynthia S. Bell
and
Rita D. Swinford
Abstract Background: Human Papilloma virus (HPV) infections are an increasingly concerning etiology for post-transplantation viral-related malignancies. The nonavalent HPV vaccine (Gardasil 9) affords transplant recipients the best opportunity for malignancy prevention, but remains underutilized. Not previously reported for solid organ transplant recipients, we studied influential factors for HPV vaccine non-initiation.
Methods: This survey, conducted from May to December 2017, examined influential fact [...] |
Intrapancreatic Parenchymal Cell Transplantation as a Possible Model for the Development of a Cell-based Therapy for Type I Diabetes MellitusAbstract (1) Background: Transplantation of isolated islets is one of the most powerful approaches to cure insulin-dependent (type I) diabetes mellitus (IDDM). Currently, the most widely used transplantation strategy is percutaneous perfusion into the liver via the portal vein. However, this approach has several drawbacks and is often limited by the large number of islets required and hypoxic damage to the grafts.
(2) Methods: In this article, we posit intrapancreatic parenchymal cell transplantation (I [...] |
Case of Lung Transplantation in a Recipient with Emphysema: Importance of Determining Alpha 1-Antitrypsin Deficiency Status for Lung TransplantationAbstract Here we present a case of a lung transplant recipient with alpha 1-antitrypsin deficiency as well as conducted a retrospective review of the United Network for Organ Sharing (UNOS) database from 1990 – 2016 specifically grouping patients with alpha-1 antitrypsin deficiency (A1ATD) and chronic obstructive pulmonary disease (COPD). |
Autoimmunity in Autologous Islet Transplantationby
Khawla F. Ali
,
Vicente T. San Martin
,
Tyler Stevens
,
Matthew Walsh
,
Rita Bottino
,
Massimo Trucco
and
Betul Hatipoglu
Abstract Total pancreatectomy (TP) is increasingly being utilized for definitive treatment in patients with debilitating chronic pancreatitis (CP). In an effort to prevent surgical diabetes, the procedure can be performed in conjunction with transplantation of islets of Langerhans recovered from the patients’ own resected pancreas (autologous islet transplantation, AIT). Given that patients undergoing TP and AIT are traditionally assumed not to be at risk for the development of beta-cell autoimmunity, it [...] |